Common Variable Immunodeficiency and Circulating TFH
| العنوان: | Common Variable Immunodeficiency and Circulating TFH |
|---|---|
| المؤلفون: | Maria M.E. de Bracco, M. Cecilia Juri, Ana Coraglia, M. Felippo, Alejandro Malbrán, Diego S. Fernadez Romero, N. Galassi |
| المصدر: | Journal of Immunology Research, Vol 2016 (2016) Journal of Immunology Research CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| بيانات النشر: | Hindawi Publishing Corporation, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Programmed Cell Death 1 Receptor, Autoimmunity, C-C chemokine receptor type 7, Granulomatous Disease, Chronic, medicine.disease_cause, T-Lymphocytes, Regulatory, CXCR5, purl.org/becyt/ford/3.2 [https], Immunology and Allergy, T-Lymphocytes, Helper-Inducer, General Medicine, Middle Aged, Interleukin-10, Interleukin 10, Icos-Cd40l, B Lymphocytes, purl.org/becyt/ford/3 [https], Female, Signal Transduction, Research Article, medicine.drug, Adult, Receptors, CXCR5, lcsh:Immunologic diseases. Allergy, Interleukin 2, Receptors, CCR7, medicine.medical_specialty, Article Subject, Cvid, CD40 Ligand, Primary Cell Culture, Immunology, Biology, Inducible T-Cell Co-Stimulator Protein, 03 medical and health sciences, Internal medicine, medicine, Humans, Lymphocyte Count, Phytohemagglutinins, Interleukin 4, Aged, CD40, Interleukins, Common variable immunodeficiency, medicine.disease, Common Variable Immunodeficiency, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Case-Control Studies, biology.protein, Interleukin-2, Circulating Tfh, Interleukin-4, lcsh:RC581-607 |
| الوصف: | CD4+ T follicular helper cells (TFH) were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II).TFHlymphocytes were characterized by expression of CXCR5 and PD-1.TFHwere higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg andTFHreg were similar in both CVID groups and in N.TFHresponded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression ofTFHcytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest thatTFHare functional in CVID and highlight the association of increased circulatingTFHwith AI and GD manifestations. |
| وصف الملف: | text/xhtml; application/pdf |
| اللغة: | English |
| تدمد: | 2314-8861 |
| DOI: | 10.1155/2016/4951587 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6641379386c72882b9175c3550790b4eTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6641379386c72882b9175c3550790b4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23148861 |
|---|---|
| DOI: | 10.1155/2016/4951587 |