المؤلفون: Matthew T. J. Halma, Mark J. A. Wever, Sanne Abeln, Didier Roche, Gijs J. L. Wuite

المصدر: Frontiers in Chemistry, Vol 10 (2022)

مصطلحات موضوعية: SARS-CoV-2, helicase, nsp13, drug repurposing, small-molecule inhibitors, natural products, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fchem.2022.1062352/fullTest; https://doaj.org/toc/2296-2646Test

الوصول الحر: https://doaj.org/article/16550a74f2184770aad41d3ed1a5db68Test

المؤلفون: James A. Collins, Matthias Prange, Thibaut Caley, Luis Gimeno, Britta Beckmann, Stefan Mulitza, Charlotte Skonieczny, Didier Roche, Enno Schefuß

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/71801ab157ac4d7195801dd0a96f3cbaTest

المؤلفون: Mattias F. Lindberg, Emmanuel Deau, Frédéric Miege, Marie Greverie, Didier Roche, Nicolas George, Pascal George, Laura Merlet, Julie Gavard, Sander J. T. Brugman, Edwin Aret, Paul Tinnemans, René de Gelder, Jan Sadownik, Eva Verhofstad, Dennis Sleegers, Sara Santangelo, Julien Dairou, Álvaro Fernandez-Blanco, Mara Dierssen, Andreas Krämer, Stefan Knapp, Laurent Meijer

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Computational Biology, Chemical Sciences not elsewhere classified, residence time assays, ray powder diffraction, differential scanning calorimetry, direct catalytic activity, 21 inhibits dyrk1a, activity studies, tyrosine phosphorylation, thermal shift, therapeutic target, tau ), targets ”, substituted 2, reveals dyrk1a, physiological characterization, physicochemical properties, phosphorylation levels, pharmacological inhibitors, multiparametric evaluations, may contribute, like profile, first target, entering safety, dyrk1a structure, cyclin d1

العلاقة: https://figshare.com/articles/journal_contribution/Chemical_Biochemical_Cellular_and_Physiological_Characterization_of_Leucettinib-21_a_Down_Syndrome_and_Alzheimer_s_Disease_Drug_Candidate/24747737Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01888.s001Test
https://figshare.com/articles/journal_contribution/Chemical_Biochemical_Cellular_and_Physiological_Characterization_of_Leucettinib-21_a_Down_Syndrome_and_Alzheimer_s_Disease_Drug_Candidate/24747737Test

المؤلفون: Tania Tahtouh (2026009), Emilie Durieu (613619), Benoît Villiers (11858283), Céline Bruyère (1912057), Thu Lan Nguyen (11501977), Xavier Fant (368732), Kwang H. Ahn (1425613), Leepakshi Khurana (3667051), Emmanuel Deau (1503121), Mattias F. Lindberg (6442715), Elodie Sévère (11858286), Frédéric Miege (1309392), Didier Roche (3027573), Emmanuelle Limanton (6478370), Jean-Martial L’Helgoual’ch (11858289), Guillaume Burgy (2025988), Solène Guiheneuf (11858292), Yann Herault (1783081), Debra A. Kendall (1319679), François Carreaux (1939042), Jean-Pierre Bazureau (2026003), Laurent Meijer (243859)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Mental Health, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, like kinases ), induced cell death, 11 purified kinases, specific kinase targets, protein kinase dyrk1a, leucettine sar observed, 5 cellular assays, kinase inhibitors, molecular targets, cellular effects, viral infections, various diseases, tau phosphorylation, potential therapeutics, pharmacological inhibitors, ones derived, mrna splicing

العلاقة: https://figshare.com/articles/journal_contribution/Structure_Activity_Relationship_in_the_Leucettine_Family_of_Kinase_Inhibitors/17298834Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01141.s001Test

المؤلفون: Gaelle Leloup, Aurélien Quiquet, Christophe Dumas, Didier Roche, Didier Paillard

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0bb91a7a76b122d08f658ee158b689e6Test
https://doi.org/10.5194/egusphere-egu22-4740Test

المؤلفون: Maxence Menthon, Pepijn Bakker, Aurélien Quiquet, Didier Roche

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3f840f6ed38f6d92a401e09951f23c44Test
https://doi.org/10.5194/egusphere-egu22-5016Test

المؤلفون: Matthew T. J. Halma, Mark J. A. Wever, Sanne Abeln, Didier Roche, Gijs J. L. Wuite

مصطلحات موضوعية: Biochemistry, Environmental Chemistry, Geochemistry, Organic Chemistry, Inorganic Chemistry, Nuclear Chemistry, Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics), Medical Biochemistry and Metabolomics not elsewhere classified, Food Chemistry and Molecular Gastronomy (excl. Wine), Analytical Biochemistry, Cell Neurochemistry, Enzymes, Electroanalytical Chemistry, Analytical Chemistry not elsewhere classified, Organic Green Chemistry, Physical Organic Chemistry, Catalysis and Mechanisms of Reactions, Environmental Chemistry (incl. Atmospheric Chemistry), SARS-CoV-2, helicase, nsp13, drug repurposing, small-molecule inhibitors, natural products, COVID-19

العلاقة: https://figshare.com/articles/dataset/DataSheet1_Therapeutic_potential_of_compounds_targeting_SARS-CoV-2_helicase_docx/21678509Test

الإتاحة: https://doi.org/10.3389/fchem.2022.1062352.s001Test
https://figshare.com/articles/dataset/DataSheet1_Therapeutic_potential_of_compounds_targeting_SARS-CoV-2_helicase_docx/21678509Test

المؤلفون: Didier Roche

المصدر: J. of Tourism and Hospitality Management ; volume 3, issue 1 ; ISSN 2328-2169 2328-2169

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.17265/2328-2169/2015.02.005Test

المؤلفون: Marcus Gastreich, Laurence Clary, Jonathan Pascau, Anne Brethon, Laurent Chantalat, Olivier Christin, Etienne Thoreau, Jean-François Fournier, Craig S. Harris, Didier Roche, T. Isabet, Vincent Rodeschini

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:5373-5377

مصطلحات موضوعية: 0301 basic medicine, Scaffold, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, CASPASE 1 INHIBITOR, Crystallography, X-Ray, Scaffold hopping, 01 natural sciences, Biochemistry, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, 4-Butyrolactone, Drug Discovery, Molecular Biology, Biological Products, Binding Sites, Natural product, 010405 organic chemistry, Caspase 1, Organic Chemistry, Hydrogen Bonding, Dipeptides, Caspase Inhibitors, Combinatorial chemistry, Protein Structure, Tertiary, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, chemistry, Docking (molecular), Molecular Medicine, Azabicyclo Compounds

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d881a80c1d0784a009d2dfbeb9d39136Test
https://doi.org/10.1016/j.bmcl.2017.11.015Test