المؤلفون: Derek J. Leishman, David L. Holdsworth, D. Adam Lauver, Marc B. Bailie, Brian M. Roche

المصدر: Clinical and Translational Science, Vol 16, Iss 11, Pp 2253-2264 (2023)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1752-8054Test; https://doaj.org/toc/1752-8062Test

الوصول الحر: https://doaj.org/article/f535042826c449bc83fae85741c955afTest

المؤلفون: Hugo M. Vargas, Eric I. Rossman, Todd A. Wisialowski, Jill Nichols, Michael K. Pugsley, Brian Roche, Gary A. Gintant, Andrea Greiter-Wilke, Robert B. Kleiman, Jean-Pierre Valentin, Derek J. Leishman

المصدر: Journal of Pharmacological and Toxicological Methods. 121:107265

مصطلحات موضوعية: Pharmacology, Toxicology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::be76a6ce3a2e0c4c2deec09e77581719Test
https://doi.org/10.1016Test/j.vascn.2023.107265

المؤلفون: Eric I. Rossman, Todd A. Wisialowski, Hugo M. Vargas, Jean-Pierre Valentin, Michael G. Rolf, Brian M. Roche, Steve Riley, Michael K. Pugsley, Jill Nichols, Dingzhou Li, Derek J. Leishman, Robert B. Kleiman, Andrea Greiter-Wilke, Gary A. Gintant, Michael J. Engwall, Annie Delaunois, Simon Authier

المصدر: Journal of Pharmacological and Toxicological Methods. :107270

مصطلحات موضوعية: Pharmacology, Toxicology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9bce4cdaca3426f8bebb1500bde7339bTest
https://doi.org/10.1016Test/j.vascn.2023.107270

المؤلفون: David Holdsworth, Derek D. Best, Katarina Haist, Kyle O'Donohue, Anson Phillips, Matthew M. Abernathy, Brian Roche, Derek J. Leishman

المصدر: Journal of Pharmacological and Toxicological Methods. 120:107253

مصطلحات موضوعية: Pharmacology, Toxicology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6ffc5c0e939c7f3fce2a64976484c7f1Test
https://doi.org/10.1016Test/j.vascn.2023.107253

المؤلفون: Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, Derek J. Leishman

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Drug, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Drug Industry, media_common.quotation_subject, Decision Making, hERG, Drug Evaluation, Preclinical, Reviews, Torsades de pointes, Review, Risk Assessment, 030226 pharmacology & pharmacy, QT interval, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Torsades de Pointes, medicine, Animals, Humans, Repolarization, Pharmacology (medical), cardiovascular diseases, Intensive care medicine, media_common, Pharmacology, biology, Surrogate endpoint, business.industry, Arrhythmias, Cardiac, Drugs, Investigational, medicine.disease, nervous system diseases, Clinical trial, Long QT Syndrome, Drug development, 030220 oncology & carcinogenesis, biology.protein, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527f989fd8c7a31101405fa082c754d4Test
https://doi.org/10.1002/cpt.2029Test

المؤلفون: Adam Hargreaves, Rob Wallis, Derek J. Leishman, Louise Leong, Steven Engle, Lorna Ewart, David E. Watson, Kathleen M. Heinz-Taheny, Philip H. Milliken, Nick McMahon, Sarah Kirk, Peter Clements, Mike Aylott, Jean-Pierre Valentin, Magali Guffroy, Renaud Fleurance, Nick Edmunds

المصدر: Toxicological Sciences. 176:224-235

مصطلحات موضوعية: Male, medicine.medical_specialty, Drug Evaluation, Preclinical, Hemodynamics, Blood Pressure, 030204 cardiovascular system & hematology, Toxicology, Cardiovascular System, 030226 pharmacology & pharmacy, Electrocardiography, 03 medical and health sciences, Dogs, 0302 clinical medicine, Heart Rate, Internal medicine, Heart rate, Animals, Telemetry, Medicine, Endocardium, Retrospective Studies, Cardiotoxicity, Dose-Response Relationship, Drug, business.industry, Surrogate endpoint, Safety pharmacology, Blood pressure, Decreased blood pressure, Cardiology, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2764b1583d31e2aea76a3e12dabc3e8Test
https://doi.org/10.1093/toxsci/kfaa051Test

المؤلفون: Adam P. Hill, Zhen Song, Haibo Ni, Norman Stockbridge, David G. Strauss, Jamie I. Vandenberg, Todd Wisialowski, Mikiko Nakamura, Takashi Yoshinaga, Godfrey L. Smith, Jill Steidl‐Nichols, Mark Holbrook, Stefano Severi, Pierre Morissette, Derek J. Leishman, Colleen E. Clancy, Gary R. Mirams, Andrea Greiter-Wilke, Andrew G. Edwards, Xiaomei Han, Zhihua Li, Flora Musuamba Tshinanu, Stefano Morotti, Stephane Nave, Aaron Fullerton, Bradley J. Ridder, Zhilin Qu, Michelangelo Paci, Alfonso Bueno-Orovio, Janell E. Chen, Thomas Singer, Peter R. Kowey, Liudmila Polonchuk, Eric A. Sobie, Blanca Rodriguez, Randall L. Rasmusson, Elisa Passini, Eleonora Grandi, Ken Wang, Michael Liu, Bruce P. Damiano, Xin Zhou

المساهمون: Li Z., Mirams G.R., Yoshinaga T., Ridder B.J., Han X., Chen J.E., Stockbridge N.L., Wisialowski T.A., Damiano B., Severi S., Morissette P., Kowey P.R., Holbrook M., Smith G., Rasmusson R.L., Liu M., Song Z., Qu Z., Leishman D.J., Steidl-Nichols J., Rodriguez B., Bueno-Orovio A., Zhou X., Passini E., Edwards A.G., Morotti S., Ni H., Grandi E., Clancy C.E., Vandenberg J., Hill A., Nakamura M., Singer T., Polonchuk L., Greiter-Wilke A., Wang K., Nave S., Fullerton A., Sobie E.A., Paci M., Musuamba Tshinanu F., Strauss D.G., Tampere University, BioMediTech, Research group: Computational Biophysics and Imaging Group

المصدر: Clinical pharmacology and therapeutics, vol 107, iss 1
Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Drug-Related Side Effects and Adverse Reactions, none, In silico, White Paper, Harmonization, Context (language use), Arrhythmias, Validation Studies as Topic, Risk prediction models, Risk Assessment, 030226 pharmacology & pharmacy, Session (web analytics), 03 medical and health sciences, 0302 clinical medicine, Consistency (negotiation), White paper, Theoretical, Models, medicine, Humans, Computer Simulation, Pharmacology (medical), Pharmacology & Pharmacy, Pharmacology, Proarrhythmia, Management science, Arrhythmias, Cardiac, 217 Medical engineering, Pharmacology and Pharmaceutical Sciences, Models, Theoretical, medicine.disease, 030220 oncology & carcinogenesis, Cardiac

وصف الملف: application/pdf; ELETTRONICO; fulltext

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2ff4e1c2fbbbeb607662c3df93ed0eTest
https://doi.org/10.1002/cpt.1647Test

المؤلفون: Stephen Jenkinson, Dingzhou Li, David J. MacEwan, Peter Kilfoil, Eric D. Watt, Derek J. Leishman, Parveen Sharma, Tiffany Lee, Asser Bassyouni, Shuyun Lily Feng

المصدر: European Journal of Pharmacology

مصطلحات موضوعية: Drug, media_common.quotation_subject, hERG, Induced Pluripotent Stem Cells, Action Potentials, Torsades de pointes, Pharmacology, QT interval, Models, Biological, QRS complex, Electrocardiography, Torsades de Pointes, Medicine, Humans, Myocytes, Cardiac, Induced pluripotent stem cell, Correlation of Data, Cells, Cultured, media_common, biology, business.industry, medicine.disease, Calcium Channel Blockers, High-Throughput Screening Assays, Drug development, ROC Curve, biology.protein, Stem cell, business, Transcriptome, Sodium Channel Blockers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354b5671ca62b0aeeb7522f5069bc852Test
https://pubmed.ncbi.nlm.nih.gov/34678241Test

المؤلفون: Nicholas D, Ether, Derek J, Leishman, Marc B, Bailie, D Adam, Lauver

المصدر: Journal of Pharmacological and Toxicological Methods. 117:107211

مصطلحات موضوعية: Pharmacology, Electrocardiography, Long QT Syndrome, Heart Rate, Moxifloxacin, Animals, Arrhythmias, Cardiac, Toxicology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebff13ac179b3bbe640ff3c607aa197Test
https://doi.org/10.1016Test/j.vascn.2022.107211

المؤلفون: Nicholas Ether, Adam Lauver, Marc Bailie, Derek J. Leishman

المصدر: The FASEB Journal. 35

مصطلحات موضوعية: Correction method, Genetics, Molecular Biology, Biochemistry, Algorithm, Biotechnology, Mathematics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::30808431668e6df0fb276da09a7c0314Test
https://doi.org/10.1096/fasebj.2021.35.s1.01569Test