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المؤلفون: Frederick W, Goldberg, Attilla K T, Ting, David, Beattie, Gillian M, Lamont, Charlene, Fallan, M Raymond V, Finlay, Beth, Williamson, Marianne, Schimpl, Alexander R, Harmer, Oladipupo B, Adeyemi, Pär, Nordell, Anna S, Cronin, Mercedes, Vazquez-Chantada, Derek, Barratt, Antonio, Ramos-Montoya, Elaine B, Cadogan, Barry R, Davies
المصدر: ACS medicinal chemistry letters. 13(8)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::2661b30d6b91249b7feab29e38d45bb4Test
https://pubmed.ncbi.nlm.nih.gov/35978693Test -
2دورية أكاديمية
المؤلفون: Jeffrey W. Johannes (1414039), Amber Balazs (9436515), Derek Barratt (8921054), Michal Bista (160356), Matthew D. Chuba (11486389), Sabina Cosulich (466728), Susan E. Critchlow (1613527), Sébastien L. Degorce (1436623), Paolo Di Fruscia (3748813), Scott D. Edmondson (1416967), Kevin Embrey (1637887), Stephen Fawell (5867138), Avipsa Ghosh (1329021), Sonja J. Gill (11486392), Anders Gunnarsson (1454497), Sudhir M. Hande (2047519), Tom D. Heightman (236769), Paul Hemsley (4414534), Giuditta Illuzzi (11486395), Jordan Lane (11486398), Carrie Larner (11486401), Elisabetta Leo (16336), Lina Liu (227490), Andrew Madin (2369338), Scott Martin (8770), Lisa McWilliams (3115182), Mark J. O’Connor (512930), Jonathan P. Orme (2570623), Fiona Pachl (1643695), Martin J. Packer (1716334), Xiaohui Pei (8775905), Andrew Pike (689657), Marianne Schimpl (208250), Hongyao She (11486404), Anna D. Staniszewska (11486407), Verity Talbot (6084164), Elizabeth Underwood (9210380), Jeffrey G. Varnes (2499496), Lin Xue (826042), Tieguang Yao (9761206), Ke Zhang (115386), Andrew X. Zhang (1371321), Xiaolan Zheng (1638844)
مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, overlapping hematological toxicities, good secondary pharmacology, brca mutant hbcx, brca mutant background, achieved regulatory approval, 17 pdx model, parp family members, oxo ‑ 5, dihydro ‑ 1, selective parp1 inhibitor, 25 b, n <, highly selective, vivo efficacy, usually due, reduced effects, recent literature, preclinical species, physicochemical properties, parps poly, parp1 inhibition, line chemotherapies
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المؤلفون: Vasudev Kantae, Radoslaw Polanski, Hilary J. Lewis, Afreen Haider, Derek Barratt, Bharath Srinivasan
المصدر: ACS Chemical Biology. 17:2366-2376
مصطلحات موضوعية: Molecular Medicine, General Medicine, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::07efb16c53ebabc031572d6ee971f369Test
https://doi.org/10.1021/acschembio.2c00483Test -
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المؤلفون: Frederick W. Goldberg, Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan, M. Raymond V. Finlay, Beth Williamson, Marianne Schimpl, Alexander R. Harmer, Oladipupo B. Adeyemi, Pär Nordell, Anna S. Cronin, Mercedes Vazquez-Chantada, Derek Barratt, Antonio Ramos-Montoya, Elaine B. Cadogan, Barry R. Davies
المصدر: ACS Medicinal Chemistry Letters. 13:1295-1301
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cf9dfca39604357a47354a464d4b09f5Test
https://doi.org/10.1021/acsmedchemlett.2c00172Test -
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المؤلفون: Jeffrey W. Johannes, Fiona Pachl, Amber Balazs, Tieguang Yao, C. Larner, Lisa McWilliams, Marianne Schimpl, Scott W. Martin, Kevin J. Embrey, Tom D. Heightman, Paul Hemsley, Jonathan P. Orme, Derek Barratt, Giuditta Illuzzi, Andrew Madin, Paolo Di Fruscia, Avipsa Ghosh, Martin J. Packer, Scott D. Edmondson, Elisabetta Leo, Xiaolan Zheng, Matthew D. Chuba, Xiaohui Pei, Mark J. O'Connor, Verity Talbot, Ke Zhang, Stephen Fawell, Elizabeth Underwood, Anna Staniszewska, Lina Liu, Lin Xue, Sonja J. Gill, Anders Gunnarsson, Andrew Pike, Susan E. Critchlow, Jeffrey G. Varnes, Andrew X. Zhang, Sébastien L. Degorce, J. Lane, Sudhir M. Hande, Hongyao She, Sabina Cosulich, Michal Bista
المصدر: Journal of Medicinal Chemistry. 64:14498-14512
مصطلحات موضوعية: chemistry.chemical_compound, PARP1, Chemistry, In vivo, Poly ADP ribose polymerase, Drug Discovery, Mutant, Cancer research, Molecular Medicine, Progenitor cell, Homologous recombination, DNA, In vitro
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5da59f02fe0bf1798c2492422c31c3Test
https://doi.org/10.1021/acs.jmedchem.1c01012Test -
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المؤلفون: Michael J. Deery, Marianne Schimpl, Derek Barratt, Hilary J. Lewis, Morgan Thomas, David Robinson, Deepa Bhavsar, Michael S. Bodnarchuk, Kirsten McAulay, Michael J. Waring, Derek Ogg, Emily A. Hoyt, Richard A. Ward, Gonçalo J. L. Bernardes, Jason Grant Kettle
المصدر: Journal of the American Chemical Society. 142:10358-10372
مصطلحات موضوعية: Models, Molecular, Molecular Structure, Chemistry, Janus Kinase 3, General Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, In vitro, Benzoxazines, 0104 chemical sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Covalent bond, Acrylamide, Electrophile, Quinazolines, Humans, Molecule, Kinome, Selectivity, Protein Kinase Inhibitors, Cysteine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698b7b9835c15e18abf6592ff62a81eeTest
https://doi.org/10.1021/jacs.9b13391Test -
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المؤلفون: Avipsa Ghosh, Sudhir M. Hande, Amber Balazs, Derek Barratt, Sabina Cosulich, Barry Davies, Sébastien Degorce, Kevin Embrey, Sonja Gill, Anders Gunnarsson, Giuditta Illuzzi, Peter Johnström, Jordan Lane, Carrie Larner, Rachel Lawrence, Elisabetta Leo, Andrew Madin, Elizabeth Martin, Lisa McWilliams, Lenka O’Connor, Mark O’Connor, Jonathan Orme, Fiona Pachl, Martin Packer, Andy Pike, Philip Rawlins, Marianne Schimpl, Magnus Schou, Anna Staniszewska, Wenzhan Yang, James Yates, Andrew Zhang, XiaoLa Zheng, Stephen Fawell, Petra Hamerlik, Jeffrey Johannes
المصدر: Cancer Research. 82:6302-6302
مصطلحات موضوعية: Cancer Research, Oncology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::288251eb61b3a0254c30186cb54c9b42Test
https://doi.org/10.1158/1538-7445.am2022-6302Test -
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المصدر: SLAS discovery : advancing life sciences RD. 26(5)
مصطلحات موضوعية: Computer science, Dissociation rate, High-throughput screening, Quantitative Structure-Activity Relationship, Computational biology, 01 natural sciences, Biochemistry, Analytical Chemistry, Small Molecule Libraries, 03 medical and health sciences, Drug Discovery, Humans, Throughput (business), 030304 developmental biology, 0303 health sciences, biology, Drug discovery, Target engagement, biology.organism_classification, Small molecule, 0104 chemical sciences, High-Throughput Screening Assays, Molecular Imaging, 010404 medicinal & biomolecular chemistry, Kinetics, Molecular Medicine, Tetra, Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ac5bb4cdb71e94951d69b607741ab5Test
https://pubmed.ncbi.nlm.nih.gov/33783249Test -
9دورية أكاديمية
المؤلفون: Puneet Khurana (7258037), Lisa McWilliams (3115182), Jonathan Wingfield (1613578), Derek Barratt (8921054), Bharath Srinivasan (1663486)
مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences not elsewhere classified, kinetics, progress curve analysis, FLIPR Tetra, high-throughput screening, covalent inhibition, slow-onset inhibition, association rate, dissociation rate, structure–kinetic relationship
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