Preferential Occurrence of Breast Carcinomas with Loss of Chromosome 16q and der(16)t(1;16)/der(1;16) in Middle‐aged Patients with Hyperplasia of Mammary Glands
| العنوان: | Preferential Occurrence of Breast Carcinomas with Loss of Chromosome 16q and der(16)t(1;16)/der(1;16) in Middle‐aged Patients with Hyperplasia of Mammary Glands |
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| المؤلفون: | Setsuo Hirohashi, Teruko Takarabe, Hitoshi Tsuda, Takashi Fukutomi |
| المصدر: | Japanese Journal of Cancer Research : Gann |
| بيانات النشر: | Blackwell Publishing Ltd, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Cancer Research, medicine.medical_specialty, Pathology, Mammary gland, Aneuploidy, Chromosomal translocation, Breast Neoplasms, Biology, Article, Translocation, Genetic, Body Mass Index, Breast cancer, Chromosome 16, medicine, Humans, Genetic Predisposition to Disease, Breast, In Situ Hybridization, Fluorescence, Hyperplasia of mammary gland, Aged, Aged, 80 and over, Chromosome Aberrations, Hyperplasia, Loss of chromosome 16, Cytogenetics, Age Factors, Cancer, Cancer etiology, Middle Aged, medicine.disease, medicine.anatomical_structure, Oncology, Chromosomes, Human, Pair 1, Female, Der(16)t(1, 16)/der(1, 16), Chromosome Deletion, Menopause, Chromosomes, Human, Pair 16 |
| الوصف: | Structural and numerical alterations of chromosome 16 are considered to be commonly involved in the genesis of breast cancer. To reveal etiological factors that predispose cells to these alterations, we examined the frequencies of chromosome 16 aneusomy, 16q loss and 1;16 fusion indicating der (16) t (1;16) / der (1;16) by multi-color fluorescence in situ hybridization in 46 tumors resected mostly from young (/= 34 years old) or elderly (/= 75 years old) women, and compared the results with those in a patient group representing a common age distribution of Japanese patients in whom chromosome 16 status in the tumor had already been studied. The correlation of these chromosome 16 alterations with age, hyperplasia in adjacent mammary glands, cancer history, and obesity indices was investigated in a total of 244 patients. In the present 46 tumors, the frequency of 16q loss and der (16) t (1;16) did not differ between 20 younger patients (30% and 15%) and 23 elderly patients (43% and 13%). However, the incidences of 16q loss and der (16) t (1;16) were low in comparison with the values of 64% and 38% in the 198 Japanese patients representing the common age distribution (P0.001). In addition, 16q loss and der (16) t (1;16) were more frequent in tumors arising in hyperplastic mammary glands (68%, 44%) than in those without (52%, 24%) (P0.01). Such correlations were not evident for 16cen aneusomy. Other etiological factors examined were not correlated with these chromosome 16 alterations. The 16q loss and der (16) t (1;16) formation were more frequently involved in the development of breast cancer in middle-aged patients than in young and elderly patients. High-level estrogens and / or sensitivity of mammary glandular cells to estrogens might induce breast cancers with structural changes of chromosome 16. |
| اللغة: | English |
| تدمد: | 1876-4673 0910-5050 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a59d236d9be394b0f1c788bf126d25Test http://europepmc.org/articles/PMC5926417Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....98a59d236d9be394b0f1c788bf126d25 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18764673 09105050 |
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