المؤلفون: Joseph E. Pero (1443532), John J. McAtee (6079199), David J. Behm (2409292), Jacques Briand (1450579), Grazyna Graczyk-Millbrandt (5870036), Karl Erhard (1993066), Andrew D. Roberts (1405717), Ralph A. Rivero (1993048), Dennis A. Holt (3024240), Brian G. Lawhorn (1523836)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Pharmacology, Biotechnology, Ecology, Infectious Diseases, Virology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, urine samples followed, urine samples collected, putative structural assignment, nmr studies led, 1 , respiratory diseases, related material, recently investigated, provide access, proposed structure, parent drug, observed drug, ion channel, identify circulating, human plasma, gsk2798745 occurred, gram quantities, excreted metabolites

العلاقة: https://figshare.com/articles/journal_contribution/Identification_Synthesis_and_Characterization_of_a_Major_Circulating_Human_Metabolite_of_TRPV4_Antagonist_GSK2798745/16543310Test

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00406.s001Test

المؤلفون: Julien C. Vantourout (9461890), Andrew M. Mason (2119783), Josephine Yuen (2485606), Graham L. Simpson (1523503), Ghotas Evindar (1370346), Letian Kuai (1264671), Michael Hobbs (7401971), Emma Edgar (5894981), Saul Needle (10063482), Xiaopeng Bai (2643814), Steve Wilson (71342), Paul Scott-Stevens (6321608), William Traylen (10063485), Kim Lambert (10063488), Neil Young (3413366), Shenaz Bunally (10063491), Scott G. Summerfield (3005832), Richard Snell (10063494), Rakesh Lad (10063497), Eric Shi (2504092), Steven Skinner (1971115), Lisa Shewchuk (1523839), Allan J.B. Watson (10063500), Chun-wa Chung (1343454), Sandeep Pal (1954993), Dennis A. Holt (3024240), Lara S. Kallander (1523863), Joanne Prendergast (5475158), Katrina Rivera (4419814), David G. Washburn (2989575), Mark R. Harpel (345389), Christopher Arico-Muendel (1665247), Albert Isidro-Llobet (1369611)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Mental Health, Hematology, Chemical Sciences not elsewhere classified, small-molecule noncovalent HSA binder, vivo half-life, AlbuBinder 1, conjugate, half-live, BMP, half-life extension technologies, Vivo Half-Life Extension, KI, Small-Molecule Human Serum Albumin ., half-life extension

العلاقة: https://figshare.com/articles/journal_contribution/_i_In_Vivo_i_Half-Life_Extension_of_BMP1_TLL_Metalloproteinase_Inhibitors_Using_Small-Molecule_Human_Serum_Albumin_Binders/13681329Test

الإتاحة: https://doi.org/10.1021/acs.bioconjchem.0c00662.s001Test

المؤلفون: Jaclyn R. Patterson (7011443), Alan P. Graves (1523860), Patrick Stoy (2698972), Mui Cheung (1523842), Tina A. Desai (11608852), Harvey Fries (1523845), Gregory J. Gatto (1523854), Dennis A. Holt (3024240), Lisa Shewchuk (1523839), Rachel Totoritis (1523827), Liping Wang (33601), Lara S. Kallander (1523863)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Inorganic Chemistry, Virology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, ray crystal structures, rat pharmacokinetic properties, discovering novel medicines, raf (> 200, reperfusion cardiac injury, promising kinase selectivity, 47 , b ‑ raf, specific kinase tnni3k, fold ), p38α, kinase selectivity, vivo <, gsk329 ), designing selectivity, therapeutic target, optimized exemplars, mouse model, favorable leads

العلاقة: https://figshare.com/articles/journal_contribution/Identification_of_Diarylurea_Inhibitors_of_the_Cardiac-Specific_Kinase_TNNI3K_by_Designing_Selectivity_Against_VEGFR2_p38_and_B_Raf/16879393Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00700.s004Test

المؤلفون: Jaclyn R. Patterson (7011443), Alan P. Graves (1523860), Patrick Stoy (2698972), Mui Cheung (1523842), Tina A. Desai (11608852), Harvey Fries (1523845), Gregory J. Gatto (1523854), Dennis A. Holt (3024240), Lisa Shewchuk (1523839), Rachel Totoritis (1523827), Liping Wang (33601), Lara S. Kallander (1523863)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Inorganic Chemistry, Virology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, ray crystal structures, rat pharmacokinetic properties, discovering novel medicines, raf (> 200, reperfusion cardiac injury, promising kinase selectivity, 47 , b ‑ raf, specific kinase tnni3k, fold ), p38α, kinase selectivity, vivo <, gsk329 ), designing selectivity, therapeutic target, optimized exemplars, mouse model, favorable leads

العلاقة: https://figshare.com/articles/dataset/Identification_of_Diarylurea_Inhibitors_of_the_Cardiac-Specific_Kinase_TNNI3K_by_Designing_Selectivity_Against_VEGFR2_p38_and_B_Raf/16879387Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00700.s002Test

المؤلفون: Jaclyn R. Patterson (7011443), Alan P. Graves (1523860), Patrick Stoy (2698972), Mui Cheung (1523842), Tina A. Desai (11608852), Harvey Fries (1523845), Gregory J. Gatto (1523854), Dennis A. Holt (3024240), Lisa Shewchuk (1523839), Rachel Totoritis (1523827), Liping Wang (33601), Lara S. Kallander (1523863)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Inorganic Chemistry, Virology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, ray crystal structures, rat pharmacokinetic properties, discovering novel medicines, raf (> 200, reperfusion cardiac injury, promising kinase selectivity, 47 , b ‑ raf, specific kinase tnni3k, fold ), p38α, kinase selectivity, vivo <, gsk329 ), designing selectivity, therapeutic target, optimized exemplars, mouse model, favorable leads

العلاقة: https://figshare.com/articles/dataset/Identification_of_Diarylurea_Inhibitors_of_the_Cardiac-Specific_Kinase_TNNI3K_by_Designing_Selectivity_Against_VEGFR2_p38_and_B_Raf/16879390Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00700.s003Test

المؤلفون: Jaclyn R. Patterson (7011443), Alan P. Graves (1523860), Patrick Stoy (2698972), Mui Cheung (1523842), Tina A. Desai (11608852), Harvey Fries (1523845), Gregory J. Gatto (1523854), Dennis A. Holt (3024240), Lisa Shewchuk (1523839), Rachel Totoritis (1523827), Liping Wang (33601), Lara S. Kallander (1523863)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Inorganic Chemistry, Virology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, ray crystal structures, rat pharmacokinetic properties, discovering novel medicines, raf (> 200, reperfusion cardiac injury, promising kinase selectivity, 47 , b ‑ raf, specific kinase tnni3k, fold ), p38α, kinase selectivity, vivo <, gsk329 ), designing selectivity, therapeutic target, optimized exemplars, mouse model, favorable leads

العلاقة: https://figshare.com/articles/dataset/Identification_of_Diarylurea_Inhibitors_of_the_Cardiac-Specific_Kinase_TNNI3K_by_Designing_Selectivity_Against_VEGFR2_p38_and_B_Raf/16879384Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00700.s001Test