دورية أكاديمية
Hypoglycemia does not affect the progression of preclinical atherosclerosis in subjects with type 2 diabetes.
| العنوان: | Hypoglycemia does not affect the progression of preclinical atherosclerosis in subjects with type 2 diabetes. |
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| المؤلفون: | Concetta Irace, Antonio Cutruzzolà, Delia Francesca Carbotti, Simona Mastroianni, Michela Cavallo, Agostino Gnasso |
| المصدر: | PLoS ONE, Vol 14, Iss 3, p e0212871 (2019) |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | INTRODUCTION:Intensive treatment aimed at achieving optimal metabolic control to prevent the development of chronic diabetic complications is often associated with an increased rate of hypoglycemic events. Hypoglycemia is believed to be responsible for acute fatal and nonfatal cardiovascular events likely as a consequence of the activation of pro-inflammatory and pro-atherothrombotic pathways. Hypoglycemia has been reported to influence the development of preclinical atherosclerosis. The present study was designed to prospectively evaluate whether hypoglycemia influences the function and the morphology of the arteries in subjects with type 2 diabetes without complications and uncontrolled diabetes. MATERIAL AND METHODS:Seventy-six subjects underwent a noninvasive evaluation of carotid wall thickness and brachial artery function at baseline and after one year of treatment with the intent of obtaining optimal glycemic control. At the end of the observation time, subjects were divided in two groups: with hypoglycemia (H-group) or without hypoglycemia (C-group). RESULTS:Baseline characteristic were comparable between groups. HbA1c significantly decreased in both groups, and fasting plasma glucose was only significant in the H-group. Subjects with hypoglycemia showed a significant reduction of carotid wall thickness after one-year of treatment (H-groups: right baseline 834±141 vs. 1-year 770±132 μ p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://doaj.org/toc/1932-6203Test |
| DOI: | 10.1371/journal.pone.0212871 |
| الوصول الحر: | https://doaj.org/article/80bf920983ef4971992ff556efe1898dTest |
| رقم الانضمام: | edsdoj.80bf920983ef4971992ff556efe1898d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0212871 |