دورية أكاديمية
Numerical characterization of astronaut CaOx renal stone incidence rates to quantify in-flight and post-flight relative risk
| العنوان: | Numerical characterization of astronaut CaOx renal stone incidence rates to quantify in-flight and post-flight relative risk |
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| المؤلفون: | Debra A. Goodenow-Messman, Suleyman A. Gokoglu, Mohammad Kassemi, Jerry G. Myers |
| المصدر: | npj Microgravity, Vol 8, Iss 1, Pp 1-17 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biotechnology LCC:Physiology |
| مصطلحات موضوعية: | Biotechnology, TP248.13-248.65, Physiology, QP1-981 |
| الوصف: | Abstract Changes in urine chemistry potentially alter the risk of renal stone formation in astronauts. Quantifying spaceflight renal stone incidence risk compared to pre-flight levels remains a significant challenge for assessing the appropriate vehicle, mission, and countermeasure design. A computational biochemistry model representing CaOx crystal precipitation, growth, and agglomeration is combined with a probabilistic analysis to predict the in- and post-flight CaOx renal stone incidence risk ratio (IRR) relative to pre-flight values using 1517 astronaut 24-h urine chemistries. Our simulations predict that in-flight fluid intake alone would need to increase from current prescriptions of 2.0–2.5 L/day to ~3.2 L/day to approach the CaOx IRR of the pre-flight population. Bone protective interventions would reduce CaOx risk to pre-flight levels if Ca excretion alone is reduced to |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2373-8065 |
| العلاقة: | https://doaj.org/toc/2373-8065Test |
| DOI: | 10.1038/s41526-021-00187-z |
| الوصول الحر: | https://doaj.org/article/7a9ae96a7e82402d91c8ccb9c95ad21cTest |
| رقم الانضمام: | edsdoj.7a9ae96a7e82402d91c8ccb9c95ad21c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23738065 |
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| DOI: | 10.1038/s41526-021-00187-z |