دورية أكاديمية

Suppression of protein degradation in progressive cardiac hypertrophy of chronic aortic regurgitation.

التفاصيل البيبلوغرافية
العنوان: Suppression of protein degradation in progressive cardiac hypertrophy of chronic aortic regurgitation.
المؤلفون: Magid, N M, Borer, J S, Young, M S, Wallerson, D C, DeMonteiro, C
المصدر: Circulation ; volume 87, issue 4, page 1249-1257 ; ISSN 0009-7322 1524-4539
بيانات النشر: Ovid Technologies (Wolters Kluwer Health)
سنة النشر: 1993
الوصف: BACKGROUND The heart adapts to the volume overload of aortic regurgitation with dilation and hypertrophy. The development of left ventricular hypertrophy at the protein level is a dynamic process resulting from an imbalance between cardiac protein synthesis and degradation. The objective of the present study was to determine in vivo the relative contributions of cardiac protein synthesis and degradation to the progressive hypertrophy that occurs in response to chronic aortic regurgitation and to compare these with responses earlier in the course of this stress. METHODS AND RESULTS Continuous intravenous infusions of [3H]-leucine were administered 3 days and 1 month after surgical induction of aortic regurgitation and sham operation in rabbits. Total cardiac protein and myosin heavy chain fractional synthesis rates were obtained by analysis of plasma and protein hydrolysate data using [14C]-dansyl chloride assays. Left ventricular growth rates were determined from serial echocardiographic and postmortem left ventricular weight and protein concentration measurements; protein degradation rates were determined by subtraction of growth rates from synthesis rates. CONCLUSIONS In comparison with sham-operated control rabbits, protein fractional synthesis rates were increased at 3 days but not at 1 month after induction of aortic regurgitation Progressive cardiac hypertrophy occurring at 1 month was caused by a decrease in protein fractional degradation rates. An increase in protein synthesis contributes only to the early phase of hypertrophy caused by acute aortic regurgitation, whereas progressive eccentric hypertrophy in chronic volume overload is due to suppression of protein degradation.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1161/01.cir.87.4.1249
DOI: 10.1161/01.CIR.87.4.1249
الإتاحة: https://doi.org/10.1161/01.cir.87.4.1249Test
رقم الانضمام: edsbas.442AD841
قاعدة البيانات: BASE