دورية أكاديمية
Tracking the turnover of SARS-CoV-2 VOCs gamma to delta in a Brazilian state (Minas Gerais) with a high-vaccination status
| العنوان: | Tracking the turnover of SARS-CoV-2 VOCs gamma to delta in a Brazilian state (Minas Gerais) with a high-vaccination status |
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| المؤلفون: | Fonseca, PLC, Moreira, FRR, De Souza, RM, Guimaraes, NR, Carvalho, NO, Adelino, TER, Alves, HJ, Alvim, LB, Candido, DS, Coelho, HP, Costa, AVB, Costa, WC, De Carvalho, AF, De Faria, BWF, De Lima, AB, De Oliveira, ES, De Souza, CSA, De Souza, FG, Dias, RC, Geddes, VEV, Godinho, IP, Goncalves, AL, Lourenco, KL, Magalhaes, RDM, Malta, FS, Medeiros, ELA, Mendes, FS, Mendes, PHBDP, Mendonca, CPTB, Menezes, AL, Menezes, D, Menezes, MT, Miguita, L, Moreira, RG, Peixoto, RB, Queiroz, DC, Ribeiro, AA, Ribeiro, APDB, Saliba, JW, Sato, H, Silva, JDP, Silva, NP, Faria, NR, Teixeira, SMR, Da Fonseca, FG, Fernandes, APSM, Zauli, DAG, Januario, JN, De Oliveira, JS, Iani, FCDM, De Aguiar, RS, De Souza, RP |
| المساهمون: | Medical Research Council-São Paulo Research Foundation (FAPESP), Wellcome Trust, Bill & Melinda Gates Foundation |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2022 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Virology, Genomic surveillance, phylogeny, phylogeography, viral lineages, vaccines, MUTATIONS, VARIANT, ESCAPE, DNA, 0603 Evolutionary Biology, 0605 Microbiology |
| الوصف: | The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2057-1577 |
| العلاقة: | Virus Evolution; http://hdl.handle.net/10044/1/99467Test; MR/S0195/1; 204311/Z/16/Z; 204311/A/16/Z; INV-034540 |
| DOI: | 10.1093/ve/veac064 |
| الإتاحة: | https://doi.org/10.1093/ve/veac064Test http://hdl.handle.net/10044/1/99467Test |
| حقوق: | © The Author(s) 2022. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0Test/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com ; https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.A6BFF174 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20571577 |
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| DOI: | 10.1093/ve/veac064 |