المؤلفون: Brian Law, Tripta Rughwani, Tenley C. Archer, Lekha Kumar, Daniel Lu, Priyanka Somanath, Yan Ma, Xiaodong Wang, David Sperandio, Steve Morris, Thorsten Kirschberg, Mini Balakrishnan, Thomas Butler

المصدر: Blood. 140:6191-6192

مصطلحات موضوعية: Immunology, Cell Biology, Hematology, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d5289e3a5d2cf691cf379d3acb110ca0Test
https://doi.org/10.1182/blood-2022-170445Test

المؤلفون: Jin Yang, Francis Grafton, Sara Ranjbarvaziri, Ana Budan, Farshad Farshidfar, Marie Cho, Emma Xu, Jaclyn Ho, Mahnaz Maddah, Kevin E. Loewke, Julio Medina, David Sperandio, Snahel Patel, Tim Hoey, Mohammad A. Mandegar

المصدر: Science translational medicine. 14(652)

مصطلحات موضوعية: Cardiomyopathy, Dilated, Heart Failure, Histone Deacetylase Inhibitors, Disease Models, Animal, Mice, Deep Learning, Animals, Myocytes, Cardiac, Stroke Volume, General Medicine, Apoptosis Regulatory Proteins, Ventricular Function, Left, Adaptor Proteins, Signal Transducing

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb087098594330648b8ab9ba7ac091b6Test
https://pubmed.ncbi.nlm.nih.gov/35896800Test

المؤلفون: Shirley Guo, Shashank Shrishrimal, Jason Cui, Guoqing Wang, Vivian Zhang, Ning Deng, Iris Dong, Anna Chen, Steve Luo, David Sperandio, Ping Cao, Wolf R. Wiedemeyer

المصدر: Cancer Research. 83:4976-4976

مصطلحات موضوعية: Cancer Research, Oncology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d652713d67ee4acf4d7ec121a44f9ee3Test
https://doi.org/10.1158/1538-7445.am2023-4976Test

المؤلفون: Wanchi Fung, Kobayashi Tetsuya, Anita Niedziela-Majka, Bob Jiang, Kim Jordan, Saritha Kusam, David G. Breckenridge, Hai Yang, Britton Kenneth Corkey, Kristyna Elbel, Chin Tay, Elaine Kan, Sammy Metobo, David Sperandio, Du Jinfa, Richard M. Neve, Sophia L. Shevick, Eric B. Lansdon, Kerim Babaoglu, Gregory Chin, Heather Webb, Debi Jin, Annapurna Sapre, Vangelis Aktoudianakis, Latesh Lad, Jamie Bates, Xiaowu Chen, Jeff Zablocki, Gene Eisenberg, Nate Larson, Richard L. Mackman, Martinez Ruben, Magdeleine Hung, Zachary Newby, Mish Michael R

المصدر: Bioorganic & Medicinal Chemistry. 27:457-469

مصطلحات موضوعية: Benzimidazole, BRD4, Cell Survival, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Protein Domains, Cell Line, Tumor, Drug Discovery, Animals, Humans, Potency, Tumor growth, Epigenetics, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Aryl, Organic Chemistry, Isoxazoles, Neoplasms, Experimental, Bioavailability, Bromodomain, chemistry, Molecular Medicine, Benzimidazoles, Multiple Myeloma, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32393d33e86182931fa91168f5389d3cTest
https://doi.org/10.1016/j.bmc.2018.11.020Test

المؤلفون: Jean-Yves Christophe Chiva, Peter Pyun, Andrew John Keats, Linos Lazarides, Karine G. Poullennec, Neil Andrew Dunbar, Brian E. Schultz, Mingzhe Ji, Gregory M. Watt, Karki Kapil Kumar, Ruby Cai, Carina E. Cannizzaro, Uli Schmitz, David Kenneth Dean, Yu-Jen Lee, Sangi Michael, Victoria Alexandra Steadman, Adam J. Schrier, Simon B. Pettit, Hans G. Fliri, Adrian John Highton, Todd C. Appleby, Carol Austin, Richard L. Mackman, Caroline A. Blakemore, Hui Hon Chung, Dustin Siegel, Gregory Chin, Bernard P. Murray, Hai Yang, Yang Tian, George Stepan, Jonathan Sanvoisin, Albert Liclican, Mish Michael R, David Sperandio, Rex Santos, Petr Jansa, Haolun Jin

المصدر: Journal of Medicinal Chemistry. 61:9473-9499

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Administration, Oral, Biological Availability, Hepacivirus, Isomerase, Pharmacology, Antiviral Agents, 01 natural sciences, Virus, Cell Line, Cyclophilins, Lactones, 03 medical and health sciences, Protein structure, Drug Discovery, Spiro Compounds, Enzyme Inhibitors, Cyclophilin, 010405 organic chemistry, Chemistry, Total synthesis, 0104 chemical sciences, Bioavailability, Ring size, 030104 developmental biology, Cell culture, Drug Design, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f349698a38c7c9924d318620a6fcc5d2Test
https://doi.org/10.1021/acs.jmedchem.8b00802Test

المؤلفون: Magdeleine Hung, Anita Niedziela-Majka, Weimei Xing, Robert Jordan, Roman Sakowicz, Dharmaraj Samuel, Xiaohong Liu, David Sperandio, Jinny S. Wong, Katherine M. Brendza, Michel Perron, Richard L. Mackman

المصدر: Antimicrobial Agents and Chemotherapy. 59:7109-7112

مصطلحات موضوعية: Pharmacology, Host cell membrane, Sulfonamides, Indazoles, Protein Conformation, Chemistry, viruses, Respiratory Syncytial Virus Infections, Antiviral Agents, Virology, Fusion protein, Virus, In vitro, Viral Proteins, Infectious Diseases, Protein structure, Viral envelope, Viral entry, Respiratory Syncytial Virus, Human, Pyrazoles, Pharmacology (medical), Respiratory system

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5192f1a7916cbf063f01e3490a7ffa81Test
https://doi.org/10.1128/aac.00761-15Test

المؤلفون: Anne Carey, Kirsten M. Stray, Brian E. Gilbert, Pedro A. Piedra, Dorothy Agnes Theodore, Kerim Babaoglu, Jay P. Parrish, Manoj C. Desai, Lijun Zhang, April Kinkade, Hai Yang, Dharmaraj Samuel, Oliver L. Saunders, Constantine G. Boojamra, Jaclyn Hayes, Robert Jordan, Sangi Michael, Eugene J. Eisenberg, David Sperandio, Dustin Siegel, Richard L. Mackman, Hui Hon Chung, Quynh Iwata, Tomas Cihlar, Michel Perron, Gary Lee, Robert G. Strickley

المصدر: Journal of Medicinal Chemistry. 58:1630-1643

مصطلحات موضوعية: Drug, Indazoles, media_common.quotation_subject, Administration, Oral, Microbial Sensitivity Tests, Respiratory Syncytial Virus Infections, Biology, medicine.disease_cause, Placebo, Antiviral Agents, Structure-Activity Relationship, Dogs, Drug Discovery, medicine, Animals, Humans, Potency, Cotton rat, EC50, media_common, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Virus Internalization, biology.organism_classification, Virology, Rats, Respiratory Syncytial Viruses, Bioavailability, Macaca fascicularis, Respiratory syncytial virus (RSV), Pyrazoles, Molecular Medicine, Viral load

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0235893242f4fde963b87e02cf869c43Test
https://doi.org/10.1021/jm5017768Test

المؤلفون: Fang Chen, Xiarong Shi, Leena Kuruvilla, Stephen Viviano, Jamie Bates, Benjamin E. Turk, Massimiliano Baldassarre, David G. Breckenridge, Peng Yue, David Sperandio, Martinez Ruben, Joseph Schlessinger, Valia T. Mihaylova, David A. Calderwood

المصدر: Proceedings of the National Academy of Sciences. 113

مصطلحات موضوعية: 0301 basic medicine, Receptor expression, Drug Resistance, Proto-Oncogene Proteins c-myc, Small hairpin RNA, 03 medical and health sciences, Transforming Growth Factor beta, Cell Line, Tumor, Humans, Gene silencing, Transcription factor, Cell Proliferation, Multidisciplinary, Molecular Structure, biology, Proteins, Azepines, Transforming growth factor beta, Triazoles, HCT116 Cells, Bromodomain, Gene Expression Regulation, Neoplastic, HEK293 Cells, 030104 developmental biology, PNAS Plus, Cancer cell, biology.protein, Cancer research, RNA Interference, Signal transduction, Colorectal Neoplasms, Receptors, Transforming Growth Factor beta, Signal Transduction, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a964241714816f2a47abb62f12d21cefTest
https://doi.org/10.1073/pnas.1608319113Test

المؤلفون: Jennifer E. Vela, Adrian S. Ray, Sparacino Mark L, James M. Chen, Richard L. Mackman, David Y. Markevitch, Oleg V. Petrakovsky, Abraham C. Barron, David Sperandio, Ying Gao, Jay P. Parrish, Choung U. Kim, Sharon K. Lee, Tomas Cihlar, Genevieve Laflamme, Constantine G. Boojamra, Manoj C. Desai

المصدر: Bioorganic & Medicinal Chemistry. 17:1739-1746

مصطلحات موضوعية: Models, Molecular, Anti-HIV Agents, Metabolite, Clinical Biochemistry, Organophosphonates, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Prodrugs, Nucleotide, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Nucleosides, Prodrug, Phosphonate, HIV Reverse Transcriptase, In vitro, Reverse transcriptase, chemistry, Drug Design, Reverse Transcriptase Inhibitors, Molecular Medicine, Nucleoside

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d31656d0e7ed412b7ae00ad6348354Test
https://doi.org/10.1016/j.bmc.2008.12.028Test

المؤلفون: David Sperandio, Shailaja Kasibhatla, Alberto Estevez, Bill Maske, Emma J. Shelton, Jeffrey R. Spencer, Sui Xiong Cai, Ben Cebon, John Drewe, Chris Reed, Jason Oeh, Ling Qiu, Peter Sabbatini, Anthony Neri, Paul A. Sprengeler, Ben Tseng, Jennifer Zeitz, Cindy Brown, Robert Yee, John Herich, Vincent W.-F. Tai, Catherine Magill, John Eksterowicz, Doris Graupe, Joane Litvak, Darren Wong, Julia Lohman, Yong Ni, Seema Kantak, Keith Pararajasingham

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:4554-4558

مصطلحات موضوعية: medicine.drug_class, Poly ADP ribose polymerase, Clinical Biochemistry, Pharmaceutical Science, Apoptosis, Carboxamide, DNA laddering, Biochemistry, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Cytotoxicity, Oxazoles, Molecular Biology, Caspase, Molecular Structure, biology, Chemistry, Organic Chemistry, Amides, Xenograft Model Antitumor Assays, Cell culture, biology.protein, Molecular Medicine, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d27287e8b70cbad29f2a44c5b17b6a6Test
https://doi.org/10.1016/j.bmcl.2006.06.018Test