-
1دورية أكاديمية
المؤلفون: Lisa Barbaro, Alice L. Rodriguez, Ashlyn N. Blevins, Jonathan W. Dickerson, Natasha Billard, Olivier Boutaud, Jerri L. Rook, Colleen M. Niswender, P.Jeffrey Conn, Darren W. Engers, Craig W. Lindsley
المصدر: ACS Bio & Med Chem Au, Vol 1, Iss 1, Pp 21-30 (2021)
مصطلحات موضوعية: Biology (General), QH301-705.5, Biochemistry, QD415-436
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2694-2437Test
-
2دورية أكاديمية
المؤلفون: Matthew Spock (11219123), Trever R. Carter (11219126), Katrina A. Bollinger (4375849), Changho Han (1309563), Logan A. Baker (11219129), Alice L. Rodriguez (1270236), Li Peng (83452), Jonathan W. Dickerson (3628004), Aidong Qi (2204728), Jerri M. Rook (1315593), Jordan C. O’Neill (3778144), Katherine J. Watson (11218010), Sichen Chang (1475053), Thomas M. Bridges (1336731), Julie L. Engers (1475044), Darren W. Engers (655505), Colleen M. Niswender (353419), P. Jeffrey Conn (1270239), Craig W. Lindsley (203380), Aaron M. Bender (5155397)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Evolutionary Biology, Sociology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, novel use, DMPK properties, movement disorders, Orally Bioavailable M 4 Muscarinic ., CYP inhibition, deuterium incorporation, SAR, M 4 mAChR antagonist, VU 6028418
-
3دورية أكاديمية
المؤلفون: Lisa Barbaro (1801921), Alice L. Rodriguez (1270236), Ashlyn N. Blevins (11569318), Jonathan W. Dickerson (3628004), Natasha Billard (11569321), Olivier Boutaud (1340007), Jerri L. Rook (11569324), Colleen M. Niswender (353419), P.Jeffrey Conn (11569327), Darren W. Engers (655505), Craig W. Lindsley (203380)
مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, site binding nam, regioisomeric methyl congener, allosteric privileged structures, allosteric ligands driven, 94 ), mpep, 83 ), p sub, 50 sub, 5 sub, 1 sub, 28d b, 17a b, site binding mglu, displayed anxiolytic activity, vivo <, reversed amphetamine, pure mglu, literature concerning, induced hyperlocomotion, growing body
-
4
المؤلفون: Sichen Chang, Jonathan W. Dickerson, Baker Logan A, Thomas M. Bridges, Craig W. Lindsley, Darren W. Engers, Aidong Qi, Jerri M. Rook, Aaron M. Bender, P. Jeffrey Conn, Katrina A. Bollinger, Colleen M. Niswender, Changho Han, Alice L. Rodriguez, Trever R Carter, Li Peng, Julie L. Engers, Jordan C. O’Neill, Matthew Spock, Katherine J. Watson
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Dystonia, Movement disorders, Chemistry, Organic Chemistry, Antagonist, Pharmacology, medicine.disease, Highly selective, Biochemistry, In vitro, Bioavailability, In vivo, Drug Discovery, Muscarinic acetylcholine receptor, medicine, medicine.symptom
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388290e5061b99e6a85f95357b9a3b32Test
https://doi.org/10.1021/acsmedchemlett.1c00363Test -
5
المؤلفون: Darren W. Engers, Natasha Billard, Colleen M. Niswender, Ashlyn N. Blevins, Olivier Boutaud, Jonathan W. Dickerson, P. Jeffrey Conn, Jerri L. Rook, Craig W. Lindsley, Alice L. Rodriguez, Lisa Barbaro
المصدر: ACS Bio & Med Chem Au, Vol 1, Iss 1, Pp 21-30 (2021)
مصطلحات موضوعية: Molecular switch, Chemotype, Chemistry, Stereochemistry, QH301-705.5, Allosteric regulation, Magic (programming), Pharmaceutical Science, QD415-436, Biochemistry, In vivo, Drug Discovery, Biology (General), Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6207100701021f062c871e381bbd20fTest
https://doaj.org/article/a1962d9086d84ecabe40eff8d58cb02fTest -
6
المؤلفون: Changho Han, J. Scott Daniels, Alice L. Rodriguez, Colleen M. Niswender, Alison R. Gregro, P. Jeffrey Conn, Michael R. Wood, Craig W. Lindsley, Katrina A. Bollinger, Michael W. Wood, Mark E. Duggan, Sichen Chang, Darren W. Engers, Atin Lamsal, Ryan D. Morrison, Andrew S. Felts, Trevor C. Chopko, Nicholas J. Brandon, Nathalie Schnetz-Boutaud, Vincent B. Luscombe, Hyekyung P. Cho, Mike Poslusney, Carrie K. Jones, Donald F. Stec, Thomas M. Bridges, Michael Bubser, Bruce J. Melancon
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:2224-2228
مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Stereochemistry, Metabolite, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Metabolism, 01 natural sciences, Biochemistry, 0104 chemical sciences, Cns penetration, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Molecular Medicine, Penetrant (biochemical), Molecular Biology, Aldehyde oxidase, Tricyclic
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c29ef3365adcf94a1df6de7318989723Test
https://doi.org/10.1016/j.bmcl.2019.06.032Test -
7
المؤلفون: Aaron M, Bender, Trever R, Carter, Matthew, Spock, Alice L, Rodriguez, Jonathan W, Dickerson, Jerri M, Rook, Sichen, Chang, Aidong, Qi, Christopher C, Presley, Darren W, Engers, Joel M, Harp, Thomas M, Bridges, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley
المصدر: Bioorganicmedicinal chemistry letters. 56
مصطلحات موضوعية: Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Receptor, Muscarinic M4, Humans, Muscarinic Antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::15d71c45fc9259c6cf1b62b08759c9b1Test
https://pubmed.ncbi.nlm.nih.gov/34838649Test -
8
المؤلفون: Madeline F, Long, Rory A, Capstick, Paul K, Spearing, Julie L, Engers, Alison R, Gregro, Sean R, Bollinger, Sichen, Chang, Vincent B, Luscombe, Alice L, Rodriguez, Hyekyung P, Cho, Colleen M, Niswender, Thomas M, Bridges, P Jeffrey, Conn, Craig W, Lindsley, Darren W, Engers, Kayla J, Temple
المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: Structure-Activity Relationship, Pyrimidines, Dose-Response Relationship, Drug, Molecular Structure, Receptor, Muscarinic M4, Drug Discovery, Humans, Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::b7d2305e24357298dbb490314b78657bTest
https://pubmed.ncbi.nlm.nih.gov/34710625Test -
9
المؤلفون: Alice L. Rodriguez, P. Jeffrey Conn, Allison R. Gregro, Michael Bubser, Mark E. Dugan, Colleen M. Niswender, Leah C. Konkol, Michael W. Wood, Darren W. Engers, Craig W. Lindsley, Jeanette L. Bertron, Bruce J. Melancon, Sean R. Bollinger, Thomas M. Bridges, Samantha E. Yohn, Vincent B. Luscombe, Andrew S. Felts, Michael R. Wood, Carrie K. Jones, Nicholas J. Brandon, Katrina A. Bollinger
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1714-1718
مصطلحات موضوعية: Allosteric modulator, 010405 organic chemistry, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Computational biology, 01 natural sciences, Biochemistry, 0104 chemical sciences, Pyridazine, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, medicine, Molecular Medicine, Moiety, Pharmaceutical sciences, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::49ea6005ae21bf03b498cfa06332687eTest
https://doi.org/10.1016/j.bmcl.2019.05.026Test -
10
المؤلفون: Joshua M. Wieting, Darren W. Engers, Haruto Kurata, Kevin M. McGowan, Takahiro Mori, Yuzo Iwaki, Thomas M. Bridges, Kentaro Yashiro, Craig W. Lindsley, Jerod S. Denton, Masaya Kokubo
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1601-1604
مصطلحات موضوعية: K2p channel, Tetrahydronaphthalenes, 010405 organic chemistry, Activator (genetics), Chemistry, Organic Chemistry, Clinical Biochemistry, Tetrazoles, Pharmaceutical Science, TWIK-RELATED K+ CHANNEL, Computational biology, 01 natural sciences, Biochemistry, Potassium channel, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Broad spectrum, Potassium Channels, Tandem Pore Domain, Human disease, Drug Discovery, Multi dimensional, Humans, Molecular Medicine, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bbe63c14adcf6638d2f3aed00c6a65Test
https://doi.org/10.1016/j.bmcl.2019.04.048Test