المؤلفون: Efren Garcia-Maldonado, Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J. Miller, Jayaraman Seetharaman, Taosheng Chen

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/c30e189d2e734c8aad1bc9b3e758e589Test

المؤلفون: Gisele Nishiguchi, Lauren G. Mascibroda, Sarah M. Young, Elizabeth A. Caine, Sherif Abdelhamed, Jeffrey J. Kooijman, Darcie J. Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M. Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J. Loughran, Ravi Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A. High, Junmin Peng, Shondra M. Pruett-Miller, Danette L. Daniels, Marjeta Urh, Anang A. Shelat, Charles G. Mullighan, Kristin M. Riching, Guido J. R. Zaman, Marcus Fischer, Jeffery M. Klco, Zoran Rankovic

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/93a742dfa7284effac1e877a18d0d84eTest

المؤلفون: Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari, Patrick Rodrigues, Elizabeth C. Griffith, Clifford T. Gee, Lei Li, Wei Li, Richard E. Lee, Zoran Rankovic, Taosheng Chen, Patrick Ryan Potts

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/b277e39e14d144a186f5155bc60329efTest

المؤلفون: Jingheng Wang (4353517), Cameron D. Buchman (5802272), Jayaraman Seetharaman (455444), Darcie J. Miller (233978), Andrew D. Huber (2834636), Jing Wu (54032), Sergio C. Chai (2234542), Efren Garcia-Maldonado (11565623), William C. Wright (8292360), Jude Chenge (3814723), Taosheng Chen (298106)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, several polar interactions, often studied together, minimize acute rejection, including hydrogen bonds, human cytochrome p450, guided mutagenesis analyses, differential tissue distribution, based dosing adjustment, share high structural, previously reported substrate, cyp3a5 enzymes metabolize, potential therapeutic development, selective cyp3a5 inhibitors, selective cyp3a5 inhibition, first cyp3a5 structure, type ii inhibitor, selective inhibitors, selective inhibition, substrate similarity, structural basis, cyp3a5 <

العلاقة: https://figshare.com/articles/journal_contribution/Unraveling_the_Structural_Basis_of_Selective_Inhibition_of_Human_Cytochrome_P450_3A5/16814699Test

الإتاحة: https://doi.org/10.1021/jacs.1c07066.s001Test

المؤلفون: Andrew D. Huber, Wenwei Lin, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen

المصدر: ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ce4f5fdd0de0b842ec1a1ac43f4309d0Test
https://doi.org/10.1124/jpet.122.524030Test

المؤلفون: Wenwei Lin, Andrew D. Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen

المصدر: Proceedings of the National Academy of Sciences. 120

مصطلحات موضوعية: Multidisciplinary

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::61d3c89847d715fe6e44247b4f80407aTest
https://doi.org/10.1073/pnas.2217804120Test

المؤلفون: Christopher D. Radka, Darcie J. Miller, Matthew W. Frank, Charles O. Rock

المصدر: The Journal of biological chemistry. 298(8)

مصطلحات موضوعية: Alanine, Bacteroidetes, Pyridoxal Phosphate, Acyl Carrier Protein, Cell Biology, Molecular Biology, Biochemistry, Lipids, Cysteic Acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2739de41a5c7861e67a80188e728d499Test
https://pubmed.ncbi.nlm.nih.gov/35760102Test

المؤلفون: Elizabeth C. Griffith, Anand Mayasundari, Darcie J. Miller, Patrick Rodrigues, Zoran Rankovic, Jaeki Min, Patrick Ryan Potts, Clifford T. Gee, Richard E. Lee, Seung Wook Yang, Xin Huang, Wenwei Lin, Taosheng Chen, Lei Li, Wei Li

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Carcinogenesis, Amino Acid Motifs, General Physics and Astronomy, medicine.disease_cause, law.invention, Substrate Specificity, 0302 clinical medicine, Ubiquitin, law, Neoplasms, Protein Interaction Mapping, lcsh:Science, Substrate Interaction, Multidisciplinary, biology, Chemistry, Cell biology, Neoplasm Proteins, 030220 oncology & carcinogenesis, Aminoquinolines, Protein Binding, endocrine system, Ubiquitin-Protein Ligases, Science, Drug development, Antineoplastic Agents, Proof of Concept Study, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Structure-Activity Relationship, Antigen, Protein Domains, Antigens, Neoplasm, medicine, Structure–activity relationship, Humans, neoplasms, mRNA Cleavage and Polyadenylation Factors, HEK 293 cells, Ubiquitination, General Chemistry, High-Throughput Screening Assays, 030104 developmental biology, HEK293 Cells, Ubiquitin ligases, Mutagenesis, biology.protein, Suppressor, lcsh:Q, Degron, Drug Screening Assays, Antitumor, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa47971633dc92fea25e759e879b4a1eTest
https://doaj.org/article/b277e39e14d144a186f5155bc60329efTest

المؤلفون: Charalampos G. Kalodimos, Paolo Rossi, Darcie J. Miller, Tamjeed Saleh, Tao Xie

المصدر: J Mol Biol

مصطلحات موضوعية: Models, Molecular, Allosteric regulation, Antineoplastic Agents, Article, Allosteric Regulation, Structural Biology, hemic and lymphatic diseases, Catalytic Domain, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, medicine, Humans, Kinase activity, neoplasms, Molecular Biology, Protein Kinase Inhibitors, Myristoylation, ABL, Kinase, Activator (genetics), Chemistry, Imatinib, medicine.disease, Drug Resistance, Neoplasm, Mutation, Cancer research, Imatinib Mesylate, Allosteric Site, medicine.drug, Chronic myelogenous leukemia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f889221c982e501df73696024f00b03Test
https://europepmc.org/articles/PMC8752476Test/

المؤلفون: Siquan Chen, Asif Zubair, Ravi C. Kalathur, M. Madan Babu, Jon P. Connelly, Darcie J. Miller, Kaley Blankenship, Min Pan, Michael A. Dyer, Jake E. Batchelder, Shondra M. Pruett-Miller, Brandt C. Huddle, Matthew J. Posgai, Scott C. Blanchard, William C. Wright, Richard H. Chapple, Samuel W. Brady, Sivaraman Natarajan, Payton Archer, John Easton, Elizabeth Stewart, Paul Geeleher, Jonathan Low, Lucy A. Godley, John D. Schuetz, Taosheng Chen, Manbir Sandhu, Burgess B. Freeman, Yingzhe Wang, Brittney Gordon

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications

مصطلحات موضوعية: Indoles, Morpholines, Science, Blotting, Western, Fluorescent Antibody Technique, Mice, Nude, General Physics and Astronomy, Phases of clinical research, Molecular Dynamics Simulation, Topoisomerase-I Inhibitor, Real-Time Polymerase Chain Reaction, Article, General Biochemistry, Genetics and Molecular Biology, Mice, Neuroblastoma, Targeted therapies, In vivo, Cell Line, Tumor, Target identification, medicine, Animals, Cytotoxic T cell, Benzothiazoles, Naphthyridines, Adverse effect, Sulfonamides, Multidisciplinary, business.industry, Drug Synergism, General Chemistry, Flow Cytometry, medicine.disease, In vitro, Enzyme Activation, Leukemia, DNA Topoisomerases, Type II, Pyrimidines, Cancer research, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a2b5d02e74e1d7df7ea7c8081df4eaTest
https://doi.org/10.1038/s41467-021-26640-xTest