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1دورية أكاديمية
المؤلفون: Christopher R. Wellaway (7148462), Ian R. Baldwin (1523716), Paul Bamborough (1343466), Daniel Barker (272779), Michelle A. Bartholomew (6566705), Chun-wa Chung (1343454), Birgit Dümpelfeld (2391988), John P. Evans (1312302), Neal J. Fazakerley (4714458), Paul Homes (1523515), Steven P. Keeling (11859605), Xiao Q. Lewell (1494235), Finlay W. McNab (11859608), Joanne Morley (633656), Deborah Needham (1859719), Margarete Neu (1840468), Antoon J. M. van Oosterhout (11859611), Anshu Pal (11859614), Friedrich B. M. Reinhard (8209701), Francesco Rianjongdee (9260972), Craig M. Robertson (1533145), Paul Rowland (1523731), Rishi R. Shah (8232807), Emma B. Sherriff (11859617), Lisa A. Sloan (1523527), Simon Teague (11859620), Daniel A. Thomas (1932538), Natalie Wellaway (2202247), Justyna Wojno-Picon (8551074), James M. Woolven (2119828), Diane M. Coe (1494211)
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequent investigations revealed, compromised kinome selectivity, mouse lung pharmacokinetic, computational docking studies, ao binding site, inhaled jak inhibitors, aldehyde oxidase metabolism, aldehyde oxidase, tyrosine kinases, specific substituents, severe asthma, receptor signaling, quinazoline series, quinazoline 2, potential issue, parent compound, lung delivery, low exposure, low concentrations, janus kinase, janus family, jak inhibitors, identify quinazolines
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2دورية أكاديمية
المؤلفون: Kenneth Down (1523722), Augustin Amour (1523692), Niall A. Anderson (4590892), Nick Barton (363978), Sebastien Campos (3847891), Edward P. Cannons (1840267), Cole Clissold (10498431), Maire A. Convery (1840459), John J. Coward (11422026), Kevin Doyle (2324602), Birgit Duempelfeld (4174972), Christopher D. Edwards (2342788), Michael D. Goldsmith (11422029), Jana Krause (2885033), David N. Mallett (1494217), Grant A. McGonagle (1330743), Vipulkumar K. Patel (2342794), James Rowedder (6112244), Paul Rowland (1523731), Andrew Sharpe (3575186), Srividya Sriskantharajah (9261425), Daniel A. Thomas (1932538), Douglas W. Thomson (1266420), Sorif Uddin (2891561), J. Nicole Hamblin (1523686), Edith M. Hessel (8267715)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Pharmacology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, positive heteroaromatic amine, orally bioavailable inhibitor, avoid glutathione trapping, clinical candidate compound, 31 b, highly selective compound, highly selective, highly potent, trp760 led, sulfonamide followed, enhance potency, embedded ames, 45 mg
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3دورية أكاديمية
المؤلفون: Julie C. L. Fournier (11448395), John P. Evans (1312302), Francesca Zappacosta (1677532), Daniel A. Thomas (1932538), Vipulkumar K. Patel (2342794), Gemma V. White (2461240), Sebastien Campos (3847891), Nicholas C. O. Tomkinson (7417448)
مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Chemical Sciences not elsewhere classified, simple chemical modification, enzymatic digest coupled, clinically relevant targets, cell lysates using, inhibit kinase activity, chemoproteomic binding assay, using activated esters, covalent binding site, covalent lysine acylation, activated ester motif, catalytic lysine across, selective kinase inactivation, conserved catalytic lysine, pi3kδ covalent inhibition, covalent binding, catalytic lysine, kinase δ, three esters, selective inhibitors, pi3kδ inhibition, conserved nature
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4
المؤلفون: Christopher R. Wellaway (7148462), Ian R. Baldwin (1523716), Paul Bamborough (1343466), Daniel Barker (272779), Michelle A. Bartholomew (6566705), Chun-wa Chung (1343454), Birgit Dümpelfeld (2391988), John P. Evans (1312302), Neal J. Fazakerley (4714458), Paul Homes (1523515), Steven P. Keeling (11859605), Xiao Q. Lewell (1494235), Finlay W. McNab (11859608), Joanne Morley (633656), Deborah Needham (1859719), Margarete Neu (1840468), Antoon J. M. van Oosterhout (11859611), Anshu Pal (11859614), Friedrich B. M. Reinhard (8209701), Francesco Rianjongdee (9260972), Craig M. Robertson (1533145), Paul Rowland (1523731), Rishi R. Shah (8232807), Emma B. Sherriff (11859617), Lisa A. Sloan (1523527), Simon Teague (11859620), Daniel A. Thomas (1932538), Natalie Wellaway (2202247), Justyna Wojno-Picon (8551074), James M. Woolven (2119828), Diane M. Coe (1494211)
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequent investigations revealed, compromised kinome selectivity, mouse lung pharmacokinetic, computational docking studies, ao binding site, inhaled jak inhibitors, aldehyde oxidase metabolism, aldehyde oxidase, tyrosine kinases, specific substituents, severe asthma, receptor signaling, quinazoline series, quinazoline 2, potential issue, parent compound, lung delivery, low exposure, low concentrations, janus kinase, janus family, jak inhibitors, identify quinazolines
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5
المؤلفون: Kenneth Down (1523722), Augustin Amour (1523692), Niall A. Anderson (4590892), Nick Barton (363978), Sebastien Campos (3847891), Edward P. Cannons (1840267), Cole Clissold (10498431), Maire A. Convery (1840459), John J. Coward (11422026), Kevin Doyle (2324602), Birgit Duempelfeld (4174972), Christopher D. Edwards (2342788), Michael D. Goldsmith (11422029), Jana Krause (2885033), David N. Mallett (1494217), Grant A. McGonagle (1330743), Vipulkumar K. Patel (2342794), James Rowedder (6112244), Paul Rowland (1523731), Andrew Sharpe (3575186), Srividya Sriskantharajah (9261425), Daniel A. Thomas (1932538), Douglas W. Thomson (1266420), Sorif Uddin (2891561), J. Nicole Hamblin (1523686), Edith M. Hessel (8267715)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Pharmacology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, positive heteroaromatic amine, orally bioavailable inhibitor, avoid glutathione trapping, clinical candidate compound, 31 b, highly selective compound, highly selective, highly potent, trp760 led, sulfonamide followed, enhance potency, embedded ames, 45 mg
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6
المؤلفون: Julie C. L. Fournier (11448395), John P. Evans (1312302), Francesca Zappacosta (1677532), Daniel A. Thomas (1932538), Vipulkumar K. Patel (2342794), Gemma V. White (2461240), Sebastien Campos (3847891), Nicholas C. O. Tomkinson (7417448)
مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Chemical Sciences not elsewhere classified, simple chemical modification, enzymatic digest coupled, clinically relevant targets, cell lysates using, inhibit kinase activity, chemoproteomic binding assay, using activated esters, covalent binding site, covalent lysine acylation, activated ester motif, catalytic lysine across, selective kinase inactivation, conserved catalytic lysine, pi3kδ covalent inhibition, covalent binding, catalytic lysine, kinase δ, three esters, selective inhibitors, pi3kδ inhibition, conserved nature