Prospective follow-up of nebivolol in the treatment of arterial hypertension
| العنوان: | Prospective follow-up of nebivolol in the treatment of arterial hypertension |
|---|---|
| المؤلفون: | Branislava Ivanovic, Danica Matic-Cvetkovic, Nebojsa Despotovic |
| المصدر: | Srpski Arhiv za Celokupno Lekarstvo, Vol 140, Iss 7-8, Pp 425-430 (2012) |
| بيانات النشر: | National Library of Serbia, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, arterial hypertension, medicine.medical_specialty, medicine.drug_class, Diastole, lcsh:Medicine, Blood Pressure, Vasodilation, Nebivolol, Young Adult, chemistry.chemical_compound, nitro-oxide, Internal medicine, Heart rate, Humans, Medicine, Benzopyrans, Beta blocker, Antihypertensive Agents, Aged, business.industry, Cholesterol, lcsh:R, General Medicine, Middle Aged, Adrenergic beta-1 Receptor Antagonists, Blood pressure, Endocrinology, Tolerability, chemistry, Ethanolamines, Hypertension, beta-blocker, Cardiology, Female, business, medicine.drug |
| الوصف: | Introduction. Nebivolol, a third-generation beta-blocker (BB) shows a highly selective beta-blockade and specific vasodilating effects due to getting free nitro-oxide from the dysfunctional endothelium. Objective. The aim of the study was to investigate the antihypertensive effect of nebivolol in patients with arterial hypertension (AH) of both sexes. Methods. Systolic and diastolic blood pressure (BP), heart rate and serum glycemia, creatinin, cholesterol and trygliceride were measured after a 6-week treatment with a single 5 mg dose of nebivolol once daily so as to assess its efficacy and metabolic effects, as well as its tolerance by using a questionnaire answered by physicians and patients. Results. Out of 520 patients with mild or moderate AH, 430 (82.7%) were treated with nebivolol as monotherapy. After a 6-week treatment with nebivolol, with very good tolerability and neutral metabolic effects, systolic BP was significantly decreased (in male from initial 165?19 to 129?12 mm Hg, and female from initial 169?22 to 132?15 mm Hg at the end of the study; average decrease 22.3%, p |
| تدمد: | 2406-0895 0370-8179 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419c0bc9b28fd5fdd3c1a283a51078e0Test https://doi.org/10.2298/sarh1208425dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....419c0bc9b28fd5fdd3c1a283a51078e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24060895 03708179 |
|---|