دورية أكاديمية
Targeting mitochondrial shape: at the heart of cardioprotection
| العنوان: | Targeting mitochondrial shape: at the heart of cardioprotection |
|---|---|
| المؤلفون: | Hernandez-Resendiz, S, Prakash, A, Loo, SJ, Semenzato, M, Chinda, K, Crespo-Avilan, GE, Dam, LC, Lu, S, Scorrano, L, Hausenloy, DJ |
| المصدر: | Basic Research in Cardiology , 118 (1) , Article 49. (2023) |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Acute myocardial infarction, Acute myocardial ischemia–reperfusion injury, Cardioprotection, Cardiovascular diseases, Heart failure, Mitochondrial morphology, Humans, Myocardium, Myocardial Infarction, Myocytes, Cardiac, Mitochondria |
| الوصف: | There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia-reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction (AMI). In this regard, perturbations in mitochondrial morphology with an imbalance in mitochondrial fusion and fission can disrupt mitochondrial metabolism, calcium homeostasis, and reactive oxygen species production, factors which are all known to be critical determinants of cardiomyocyte death following acute myocardial IRI. As such, therapeutic approaches directed at preserving the morphology and functionality of mitochondria may provide an important strategy for cardioprotection. In this article, we provide an overview of the alterations in mitochondrial morphology which occur in response to acute myocardial IRI, and highlight the emerging therapeutic strategies for targeting mitochondrial shape to preserve mitochondrial function which have the future therapeutic potential to improve health outcomes in patients presenting with AMI. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10182471/1/Hausenloy_Targeting%20mitochondrial%20shape_VoR.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10182471Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10182471/1/Hausenloy_Targeting%20mitochondrial%20shape_VoR.pdfTest https://discovery.ucl.ac.uk/id/eprint/10182471Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.30B7E9C9 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |