التفاصيل البيبلوغرافية
| العنوان: |
Headache in Multiple Sclerosis: A Narrative Review. |
| المؤلفون: |
Adamczyk, Bożena, Morawiec, Natalia, Boczek, Sylwia, Dańda, Karol, Herba, Mikołaj, Spyra, Aleksandra, Sowa, Agata, Szczygieł, Jarosław, Adamczyk-Sowa, Monika |
| المصدر: |
Medicina (1010660X); Apr2024, Vol. 60 Issue 4, p572, 15p |
| مصطلحات موضوعية: |
PRIMARY headache disorders, MULTIPLE sclerosis, HEADACHE, MIGRAINE, DEMYELINATION, CENTRAL nervous system |
| مستخلص: |
Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system characterized by autoimmune-mediated damage to oligodendrocytes and subsequent myelin destruction. Clinical implications: Clinically, the disease presents with many symptoms, often evolving over time. The insidious onset of MS often manifests with non-specific symptoms (prodromal phase), which may precede a clinical diagnosis by several years. Among them, headache is a prominent early indicator, affecting a significant number of MS patients (50–60%). Results: Headache manifests as migraine or tension-type headache with a clear female predilection (female-male ratio 2-3:1). Additionally, some disease-modifying therapies in MS can also induce headache. For instance, teriflunomide, interferons, ponesimod, alemtuzumab and cladribine are associated with an increased incidence of headache. Conclusions: The present review analyzed the literature data on the relationship between headache and MS to provide clinicians with valuable insights for optimized patient management and the therapeutic decision-making process. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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