Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines
| العنوان: | Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines |
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| المؤلفون: | Yi Guo, Mingshi Yang, Li Zhang, Changzhi Shi, Dongmei Cun, Hriday Bera |
| المصدر: | Acta Pharmaceutica Sinica. B Guo, Y, Bera, H, Shi, C, Zhang, L, Cun, D & Yang, M 2021, ' Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines ', Acta Pharmaceutica Sinica B, vol. 11, no. 8, pp. 2565-2584 . https://doi.org/10.1016/j.apsb.2021.05.015Test Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2565-2584 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | PLA, polylactic acid, MPP, mucus-penetrating particles, PLGA, poly(lactic-co-glycolic acid), Review, CS, chitosan, Pulmonary exposure, MW, molecular weight, PVA, polyvinyl alcohol, 0302 clinical medicine, Inhaled sustained release formulations, BALF, bronchoalveolar lavage fluid, General Pharmacology, Toxicology and Pharmaceutics, Patient compliance, COPD, chronic obstructive pulmonary diseases, HA, hyaluronic acid, DPIs, dry powder inhalers, 0303 health sciences, DPPC, dipalmitoylphosphatidylcholine, FDA, US food and drug administration, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Obstructive Pulmonary Diseases, API, active pharmaceutical ingredient, NLCs, nanostructured lipid carriers, Clearance, medicine.medical_specialty, LABA, long-acting β2-adrenoceptor agonist, RM1-950, IL-5, interleukin-5, PCL, poly-ε-caprolactone, 03 medical and health sciences, LPPs, large porous particles, medicine, FDKP, fumaryl diketopiperazine, Intensive care medicine, Pharmaceutical strategies, Systemic diseases, Da, aerodynamic diameters, 030304 developmental biology, Asthma, PEG, polyethylene glycol, Lung, PVA - Polyvinyl alcohol, business.industry, DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine, Therapeutic effect, Drug administration, Pulmonary clearance pathways, MP, mucoadhesive particles, medicine.disease, Pulmonary drug delivery, SLNs, solid lipid nanoparticles, PDD, pulmonary drug delivery, Tmax, time of maximum concentration, ALIS, amikacin liposomal inhalation suspension, Mn, number-average molecular weight, MDIs, metered dose inhalers, Pulmonary safety, IL-4, interleukin-4, MCE, mucociliary escalator, PK, pharmacokinetics, Therapeutics. Pharmacology, ELF, epithelial lining fluid, business, Local lung diseases |
| الوصف: | Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory infections, and systemic diseases such as diabetes. Most inhaled medicines could be cleared rapidly from the lungs and their therapeutic effects are transit. The inhaled medicines with extended pulmonary exposure may not only improve the patient compliance by reducing the frequency of drug administration, but also enhance the clinical benefits to the patients with improved therapeutic outcomes. This article systematically reviews the physical and chemical strategies to extend the pulmonary exposure of the inhaled medicines. It starts with an introduction of various physiological and pathophysiological barriers for designing inhaled medicines with extended lung exposure, which is followed by recent advances in various strategies to overcome these barriers. Finally, the applications of the inhaled medicines with extended lung exposure for the treatment of various diseases and the safety concerns associated to various strategies to extend the pulmonary exposure of the inhaled medicines are summarized. Graphical abstract Strategies including molecular modification, polymeric conjugation, formulation technologies, etc. are being developed to extend pulmonary drug exposure. Inhaled medicines with extended lung exposure could be potentially favored for therapeutic efficacy.Image 1 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2211-3843 2211-3835 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ad93be5bd1dd39fb79dc4d37488c35Test http://europepmc.org/articles/PMC8424368Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....35ad93be5bd1dd39fb79dc4d37488c35 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22113843 22113835 |
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