المؤلفون: Sajjadi, S Ahmad, Phelan, Michael, Yan, Rui, Ho, Chu-Ching, Scambray, Kiana, Woodworth, Davis, Corrada, Maria, Kawas, Claudia

المصدر: ANNALS OF NEUROLOGY. 88(S25)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Autoimmunity, DQ0602, Jurkat, Narcolepsy, TCR, Tetramer, Neurology & Neurosurgery, Clinical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0h5448d0Test

المؤلفون: Luo, Guo, Ambati, Aditya, Lin, Ling, Bonvalet, Mélodie, Partinen, Markku, Ji, Xuhuai, Maecker, Holden Terry, Mignot, Emmanuel Jean-Marie

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2018 Dec . 115(52), E12323-E12332.

الوصول الحر: https://www.jstor.org/stable/26573970Test

المؤلفون: Luo, Guo, Ambati, Aditya, Lin, Ling, Bonvalet, Melodie, Partinen, Markku, Ji, Xuhuai, Maecker, Holden Terry, Mignot, Emmanuel Jean-Marie

المساهمون: Clinicum, Department of Neurosciences, Neurologian yksikkö, University of Helsinki, HUS Neurocenter

مصطلحات موضوعية: narcolepsy, TCR, autoimmunity, DQ0602, tetramer, CD4(+) T-CELLS, ASSOCIATION, ANTIBODIES, PANDEMRIX, NEURONS, ONSET, AUTOANTIBODIES, CATAPLEXY, VARIANTS, ABSENCE, 3112 Neurosciences, 3124 Neurology and psychiatry

وصف الملف: application/pdf

العلاقة: We thank Dr. K. Christopher Garcia for providing plasmids and insect cell lines, the Emory NIH Tetramer Core Facility (NIAID-HHSN272201300006C) for sharing DQA1*01: 02/DQB1*06: 02 expression constructs, Wenchao Sun from the Advanced Drug Delivery Lab (BioADD) for fast protein liquid chromatography isolation of biotin-labeled DQ0602, and Selina Yogeshwar for editing. The study was primarily funded by gifts from Wake Up Narcolepsy, Jazz Pharmaceutical, and individual patients to Stanford University. Some samples have been gathered by defunct NIH Grant P50-NS-23724 (to E.M.; ended in 2016). Bulk Sequencing, past DQ0602 screening, and some sample collection has been funded by a prior grant from Glaxo Smith Kline, supervised by the European Medical Agency (ended in 2014), with corresponding data reported in Ollila et al. (28). Note that none of the authors have been involved in the generation of the ELISpot results reported in the retracted De la Herran-Arita et al. publication (18, 41), as determined by a review of Stanford's internal investigation report by the NIH Office of Research Integrity. This work used the Genome Sequencing Service Center by Stanford Center for Genomics and Personalized Medicine Sequencing Center, supported by the Grant Award NIH S10OD020141.; Luo , G , Ambati , A , Lin , L , Bonvalet , M , Partinen , M , Ji , X , Maecker , H T & Mignot , E J-M 2018 , ' Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy ' , Proceedings of the National Academy of Sciences of the United States of America , vol. 115 , no. 52 , pp. E12323-E12332 . https://doi.org/10.1073/pnas.1818150116Test; ORCID: /0000-0002-8182-9368/work/68614738; 85059216951; d7404ff2-8bdb-4995-a050-d3b409a2f6c8; http://hdl.handle.net/10138/292422Test; 000454302600026

الإتاحة: http://hdl.handle.net/10138/292422Test

المؤلفون: Guo Luo, Markku Partinen, Holden T. Maecker, Mélodie Bonvalet, Aditya Ambati, Emmanuel Mignot, Xuhuai Ji, Ling Lin

المساهمون: Clinicum, Department of Neurosciences, Neurologian yksikkö, University of Helsinki, HUS Neurocenter

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, CD4(+) T-CELLS, 0301 basic medicine, narcolepsy, PANDEMRIX, VARIANTS, medicine.disease_cause, Autoantigens, 3124 Neurology and psychiatry, Autoimmunity, Epitopes, Influenza A Virus, H1N1 Subtype, Immunology and Inflammation, 0302 clinical medicine, HLA-DQ beta-Chains, Pandemrix, Child, NEURONS, Multidisciplinary, HLA-DQB1, Vaccination, autoimmunity, Intracellular Signaling Peptides and Proteins, ASSOCIATION, Middle Aged, Biological Sciences, ABSENCE, 3. Good health, Molecular mimicry, Hemagglutinins, DQ0602, PNAS Plus, Influenza A virus, Female, CATAPLEXY, TCR, Adult, Adolescent, Receptors, Antigen, T-Cell, chemical and pharmacologic phenomena, Biology, 03 medical and health sciences, Immune system, Antigen, Influenza, Human, medicine, Humans, Orexins, tetramer, Molecular Mimicry, T-cell receptor, 3112 Neurosciences, medicine.disease, 030104 developmental biology, ANTIBODIES, ONSET, Immunology, AUTOANTIBODIES, Peptides, 030217 neurology & neurosurgery, Narcolepsy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7984b342713f2394ec7252f97e5b3bTest
https://doi.org/10.1073/pnas.1818150116Test