المؤلفون: Yuanjin Zhang, Yuanqing Guo, Yeye Xu, Jie Liu, Jian Lu, Xin Wang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2973-2982 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NCBI, National Center for Biotechnology Information, TALEN, transcriptional activators like effector nucleases, RNP, ribonucleoprotein, Review, Gene editing, SREBP-2, sterol regulatory element-binding protein 2, 0302 clinical medicine, AAV, adeno-associated virus, Genome editing, DDI, drug–drug interaction, CRISPR, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, HDR, homology directed repair, tracRNA, trans-activating crRNA, ADMET, absorption, distribution, metabolism, excretion and toxicity, HIV, human immunodeficiency virus, 030220 oncology & carcinogenesis, CRISPR-Cas9, OATP1B, organic anion transporting polypeptides 1B, Rat model, CRISPR-Cas, clustered regularly interspaced short palindromic repeats-CRISPR-associated, pre-crRNA, pre-CRISPR RNA, Computational biology, RM1-950, 03 medical and health sciences, Animal model, Pharmacokinetics, TALE, transcriptional activator-like effector, ZFN, zinc finger nucleases, DSB, double-strand break, PAM, protospacer-associated motif, Gene knockout, BSEP, bile salt export pump, 030304 developmental biology, Drug metabolism, KO, knockout, Mechanism (biology), sgRNA, single guide RNA, crRNAs, CRISPR RNAs, WT, wild-type, HBV, hepatitis B virus, T7E I, T7 endonuclease I, NHEJ, non-homologous end joining, SD, Sprague–Dawley, OTS, off-target site, DMPK, drug metabolism and pharmacokinetics, Therapeutics. Pharmacology, HPV, human papillomaviruses

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953da916a138cd7d6b71c2e8c8f9668aTest
http://www.sciencedirect.com/science/article/pii/S2211383521000113Test

المؤلفون: Ahmad Abu Awwad, Tawfiq Arafat, and Oliver J Schmitz

مصطلحات موضوعية: Dried Blood Spot, Quantitation, LC-Orbitrap MS, Nicotine, Cotinine, Nic: Nicotine, Cot: Cotinine, DBS: Dried blood spot, IS: Internal standard, TCA: trichloroacetic, TRC: Torento Research chemicals, DMPK: Drug Metabolism and Pharmacokinetics, H-ESI: heated-electrospray ionization source, LLOQ: Lower Limit of Quantification, QC: Quality Control, EMA: European Medicines Agency, MF: Matrix Factor, TIC: total Ion Current, RSD: Relative Standard Deviation

وصف الملف: application/pdf

العلاقة: http://medcraveonline.com/JAPLR/JAPLR-03-00070.pdfTest

الإتاحة: http://medcraveonline.com/JAPLR/JAPLR-03-00070.pdfTest

المؤلفون: David J. Mooney, Andrew S. Khalil, Rudolf Jaenisch

المصدر: Advanced Drug Delivery Reviews

مصطلحات موضوعية: Drug Evaluation, Preclinical, Preclinical studies, Pharmaceutical Science, 02 engineering and technology, hESC, human embryonic stem cell, NTD, neural tube closure defect, GEM, genetically engineered mouse, NIH, United States National Institutes of Health, Neoplasms, hiPSC, human induced pluripotent stem cell, Drug Discovery, DMPK, drug metabolism and pharmacokinetics studies, 2D, two-dimensional, media_common, Stem cell engineering, PKPD, Pharmacokinetic-pharmacodynamic studies, Vaccines, 0303 health sciences, Neurodegenerative Diseases, HTS, high-throughput screen, 021001 nanoscience & nanotechnology, MPS, microphysiological system, ECM, extracellular matrix, Disease modeling, Risk analysis (engineering), Drug development, Microphysiological systems, Models, Animal, 0210 nano-technology, FDA, United States Food and Drug Administration, Drug, BBB, blood-brain barrier, media_common.quotation_subject, Bioengineering, ADME, absorption, distribution, metabolism, and excretion studies, In Vitro Techniques, Models, Biological, Article, PK, drug pharmacokinetics, 03 medical and health sciences, Lack of efficacy, Animals, Humans, Engineering tool, Tissue engineering, Obesity, 030304 developmental biology, 3D, three-dimensional, HCT, human clinical trials, Clinical trial, DARPA, United States Defense Advanced Research Projects Agency, hPSC, human pluripotent stem cell, PD, drug pharmacodynamics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27450d16dc16ed032dd279f5267ef128Test
https://doi.org/10.1016/j.addr.2020.09.012Test

المؤلفون: Jiashu, Xie, Zhengqiang, Wang

المصدر: Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Drug metabolism, SARS-CoV-2, GS-441524, Remdesivir, COVID-19, EPI, enhanced product ion, HINTs, histidine triad nucleotide binding proteins, MLMs, mouse liver microsomes, TAF, tenofovir alafenamide, ADK, adenosine kinase, Oral bioavailability, HLMs, human liver microsomes, IDA, information dependent acquisition, SOF, sofosbuvir, Cobi, cobicistat, CYP, cytochrome P450, Original Article, Nucleoside, DMPK, drug metabolism and pharmacokinetics, EMS, enhanced mass scan, RDV, remdesivir, Antiviral, RdRp, RNA-dependent RNA-polymerases, FIPV, feline infectious peritonitis coronavirus, MRM, multiple reaction monitoring

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::f556de7e070ad43ba50873d24a0f8940Test
https://pubmed.ncbi.nlm.nih.gov/34221871Test

المؤلفون: Toshio TERAMURA

المصدر: Drug Metabolism and Pharmacokinetics. 2001, 16(5):466

المؤلفون: Mital, Alka, Murugesan, Dinakaran, Kaiser, Marcel, Yeates, Clive, Gilbert, Ian H.

المصدر: European Journal of Medicinal Chemistry

مصطلحات موضوعية: Cell Survival, Plasmodium berghei, Plasmodium falciparum, Medicinal chemistry, SAR, structure-activity relationship, Cell Line, WHO-TDR, World Health Organisation Programme for Research and Training in Tropical Diseases, Antimalarials, Mice, Structure-Activity Relationship, Parasitic Sensitivity Tests, parasitic diseases, Drug Discovery, Animals, Humans, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Malaria, Rats, Disease Models, Animal, Solubility, Microsomes, Liver, DMPK, drug metabolism and pharmacokinetics, Phenotypic hit, WHO, World Health Organisation, Research Paper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3adf08dd0eb57648c7d8c8ba1906da77Test
http://europepmc.org/articles/PMC4607724Test