المؤلفون: Bonnet, Pierre, L, Le Gal, Solène, Gautier, Chloé, Hoffmann, Claire, V, Le Nan, Nathan, Happe, André, Le Berre, Rozenn, Saraux, Alain, Nevez, Gilles

المساهمون: Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Université d'Angers (UA), Université de Brest (UBO), Laboratoire de Parasitologie et Mycologiede CHRU Brest, Infections Respiratoires Fongiques (IRF), Université d'Angers (UA)-Université de Brest (UBO), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM)

المصدر: ISSN: 0066-4804.

مصطلحات موضوعية: Pneumocystis jirovecii dhfr dihydrofolate reductase genetic diversity methotrexate, Pneumocystis jirovecii, dhfr, dihydrofolate reductase, genetic diversity, methotrexate, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology

العلاقة: hal-04301221; https://hal.science/hal-04301221Test; https://hal.science/hal-04301221/documentTest; https://hal.science/hal-04301221/file/Bonnet,%20AAC,%202022_DHFR-MTX.pdfTest

الإتاحة: https://doi.org/10.1128/aac.00990-22Test
https://hal.science/hal-04301221Test
https://hal.science/hal-04301221/documentTest
https://hal.science/hal-04301221/file/Bonnet,%20AAC,%202022_DHFR-MTX.pdfTest

المؤلفون: Simone Ladeia-Andrade, Rodrigo M. Corder, Marcelo U. Ferreira, Gabriel W. Rangel, Igor Cavallini Johansen, Taís Nóbrega de Sousa, José Pedro Gil

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 9-24 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: 0301 basic medicine, Primaquine, Ex vivo assays, Plasmodium vivax, CQ, chloroquine, pvmdr-1, Plasmodium vivax multidrug resistance 1, Drug resistance, Infectious and parasitic diseases, RC109-216, G6PD, glucose-6-phosphate dehydrogenase, 0302 clinical medicine, Chloroquine, MEDICAMENTO, TBM, transmembrane domain, Pharmacology (medical), biology, SP, sulphadoxine-pyrimethamine, Special issue articles on 'Drug Resistance', Infectious Diseases, cPQ, carboxyprimaquine, SNP, single-nucleotide polymorphism, medicine.drug, medicine.medical_specialty, DCQ, desethylchloroquine, QN, quinine, 030231 tropical medicine, EDTA, ethylenediamine tetraacetic acid, 03 medical and health sciences, Antimalarials, DHPS, dihydropteroate synthase, parasitic diseases, medicine, Malaria, Vivax, Humans, Intensive care medicine, Chloroquine resistance, TQ, tafenoquine, ACT, antemisinin-based combination therapy, Pharmacology, Resistance (ecology), business.industry, pvcrt-o, Plasmodium vivax chloroquine resistance transporter ortholog, IMDM, Iscove's modified Dulbecco's medium, Molecular markers, medicine.disease, biology.organism_classification, DHFR, dihydrofolate reductase, bp, base pairs, 030104 developmental biology, MAO-A, Monoamine oxidase A, CYP2D6, cytochrome P450 2D6, DEN, dextromethorphan, PQ, primaquine, Parasitology, business, Malaria, MQ, mefloquine, Clinical studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e5ae265fa9864da475e8994bd43548Test
http://www.sciencedirect.com/science/article/pii/S221132072030049XTest

المؤلفون: Jansen Gerrit, Weijers Karin, Blits Marjolein, van der Heijden Joost, Gent Yoony, Al Marjon, van der Laken Conny, Molthoff Carla, Verweij Cor, Voskuijl Alexandre, Lems Willem, Scheper Rik, Peters Godefridus, Ratnam Manohar, Aassaraf Yehuda, Dijkmans Ben

المصدر: Pteridines, Vol 24, Iss 1, Pp 21-26 (2013)

مصطلحات موضوعية: antifolates, folates, rheumatoid arthritis, abbreviations and enzyme codes: atic/aicartf, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (ec 2.1.2.3), dhfr, dihydrofolate reductase (ec 1.5.1.3), fpgs, folylpolyglutamate synthetase (ec 6.3.2.17), frα/β, folate receptor alpha/beta, gart, glycinamideribonucleotide formyltransferase (ec 2.1.2.2), ggh/fpgh, gamma-glutamyl hydrolase/folylpolyglutamate hydrolyse (ec 3.4.19.9), mthfr, methylenetetrahydrofolate reductase (ec 1.5.1.20), mtx, methotrexate, pb, peripheral blood, pcft/slc46a1, proton-coupled folate transporter, pg, polyglutamates, rfc/slc19a1, reduced folate carrier, tyms, thymidylate synthase (ec 2.1.1.45)., Crystallography, QD901-999

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/0933-4807Test; https://doaj.org/toc/2195-4720Test

الوصول الحر: https://doaj.org/article/e593d5a56a1546ec9a04bf4a34f6331dTest

المؤلفون: Tejashree Pradip Waingankar, Patrick D'Silva

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Immunoprecipitation, Protein subunit, Magmas, mitochondria-associated granulocyte-macrophage colony-stimulating factor signaling molecule, mtHsp70, mitochondrial heat shock protein 70, Mitochondrion, Biochemistry, Cell Line, ROS, reactive oxygen species, TIM, translocase of inner membrane, TOM, translocase of outer membrane, Magmas, Mitochondrial Precursor Protein Import Complex Proteins, Humans, Inner membrane, Translocase, Molecular Biology, IMS, intermembrane space, protein translocation, biology, Chemistry, Co-IP, coimmunoprecipitation, DNAJC19, Cell Biology, DHFR, dihydrofolate reductase, IM, inner membrane, Mitochondria, Cell biology, Protein Transport, Ni-NTA, nickel-nitrilotriacetic acid, Mitochondrial Membranes, Mutation, Translocase of the inner membrane, biology.protein, protein import, GM-CSF, granulocyte-macrophage colony-stimulating factor, Intermembrane space, MTS, mitochondrial targeting sequence, mitochondrial translocase of inner membrane, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762162a259c5ff20569998a55943f575Test
https://doi.org/10.1016/j.jbc.2021.101349Test

المؤلفون: Johannes Meiser, Alexei Vazquez, Matthias Pietzke

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 33, Iss, Pp 23-37 (2020)

مصطلحات موضوعية: 0301 basic medicine, Formates, H-COOH, formate, CH2-THF, 5,10-methylene-THF, Disease, ADH2, alcohol dehydrogenase 2, chemistry.chemical_compound, 0302 clinical medicine, TYMS, thymidylate synthase, MS, methionine synthase, GSH, glutathione, SSAO, semicarbazide-sensitive amine oxidase, MTHFD2, methylene-THF dehydrogenase 2, MTHFR, methylene-THF reductase, Cancer, Formate metabolism, IDO, indoleamine 2,3-dioxygenase, XOR, xanthine oxidoreductase, 10-CHO-THF, 10-formyl tetrahydrofolate, Host-Pathogen Interactions, ALDH1L2, aldehyde dehydrogenase 1 like 2, Female, MAT, S-adenosyl-methionine synthetase, lcsh:Internal medicine, education, MTHFD2L, methylene-THF dehydrogenase 2L, THF, tetrahydrofolate, TOD2, tryptophan 2,3-dioxygenase, SAM, S-adenosyl-methionine, 030209 endocrinology & metabolism, Context (language use), Computational biology, Biology, CHO-GSH, S-formyl glutathione, Article, 03 medical and health sciences, H-CHO, formaldehyde, Humans, Formate, Obesity, Microbiome, Neurodegeneration, lcsh:RC31-1245, Molecular Biology, MTHFD1L, methylene-THF dehydrogenase 1L, One-carbon-metabolism, ALDH2, aldehyde dehydrogenase 2, MTAP, methylthioadenosine phosphorylase, Cell Biology, Metabolism, Human physiology, MTHFD1, methylene-THF dehydrogenase 1, Gut microbiome, Diet, Gastrointestinal Microbiome, DHFR, dihydrofolate reductase, Immune system, 030104 developmental biology, chemistry, MTA, methylthioadenosine, ALDH1L1, aldehyde dehydrogenase 1 like 1, CH3-OH, methanol, CH3-THF, 5-methyl tetrahydrofolate, ADH5, alcohol dehydrogenase 5, CH2OH-GSH, S-hydroxymethyl glutathione

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824a25583cc9166fcc54df7a1e406115Test
https://eprints.gla.ac.uk/193911/1/193911.pdfTest

المؤلفون: Karl J. Lackner, Siyer Roohani, Maximilian Kopp, Philipp Welschof, Serge P. Bottari, Andreas Daiber, Matthias Oelze, Philip Wenzel, Ning Xia, Ute Gödtel-Armbrust, Eric Mayoux, Huige Li, Leszek Wojnowski, Thomas Münzel, Swenja Kröller-Schön, Sebastian Steven, Alina Hanf, Eberhard Schulz, Fatemeh Kashani

المصدر: Redox Biology
Redox Biology, Vol 13, Iss C, Pp 370-385 (2017)

مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system diseases, Diabetic Cardiomyopathies, FPS-ZM1, RAGE inhibitor, Clinical Biochemistry, Aorta, Thoracic, RAGE, receptor for AGE, ICAM-1, intercellular adhesion molecule-1, ECL, enhanced chemiluminescence, 030204 cardiovascular system & hematology, DPP-4, dipeptidyl peptidase-4, medicine.disease_cause, TNF-α, tumor necrosis factor-α, Biochemistry, eNOS, endothelial •NO synthase (type 3), 0302 clinical medicine, Glucosides, ecSOD, extracellular superoxide dismutase, Insulin-Secreting Cells, CCL-2, see MCP-1, Hyperlipidemia, Hyperinsulinemia, GTN, glyceryl trinitrate (nitroglycerin), IFN-γ, interferon-γ, DHE, dihydroethidine, Endothelial dysfunction, IL-6, interleukin-6, lcsh:QH301-705.5, HO-1, heme oxygenase-1, lcsh:R5-920, ICAM-1, NG, normoglycemia, Diabetes, Nox, catalytic subunit of NADPH oxidase, SGLT2 inhibitor, β-cell content, L-012, 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4-(2H,3H)dione sodium salt, ChIP, chromatin immunoprecipitation, C-Reactive Protein, CRP, C-reactive protein, AGE, advanced glycation end products, HbA1c, glycohemoglobin, lcsh:Medicine (General), Research Paper, Zucker diabetic fatty rats, medicine.medical_specialty, DMSO, dimethylsulfoxide, MCP-1, monocyte-chemoattractant-protein-1, qRT-PCR, quantitative reverse transcription polymerase chain reaction, ZDF, Zucker diabetic fatty (rat), Low-grade inflammation, 03 medical and health sciences, ROS, reactive oxygen species, Sodium-Glucose Transporter 2, Physiology (medical), Internal medicine, Diabetes mellitus, PKC, protein kinase C, Empagliflozin, medicine, Animals, Hypoglycemic Agents, Benzhydryl Compounds, COX2, cyclooxygenase-2, SGLT2i, SGLT2 inhibitor, Sodium-Glucose Transporter 2 Inhibitors, Glycated Hemoglobin, ACh, acetylcholine, business.industry, Organic Chemistry, nutritional and metabolic diseases, Type 2 Diabetes Mellitus, medicine.disease, H2K9me2, histone3 lysine9 dimethylation, Rats, Rats, Zucker, DHFR, dihydrofolate reductase, SGLT2, sodium-glucose co-transporter-2, Oxidative Stress, sGC, soluable guanylyl cyclase, Glucose, 030104 developmental biology, Endocrinology, lcsh:Biology (General), ALDH-2, mitochondrial aldehyde dehydrogenase, Endothelium, Vascular, AGE/RAGE signaling, HG, hyperglycemia, business, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac2319499ec3825e6d4ca81494cb48bTest
https://doi.org/10.1016/j.redox.2017.06.009Test

المؤلفون: D. Neil Granger, Peter R. Kvietys

المصدر: Redox Biology

مصطلحات موضوعية: EC-SOD, extracellular superoxide dismutase, O2, molecular oxygen, Uncoupled nitric oxide synthase, nNOS, neuronal nitric oxide synthase, Biochemistry, TNF-α, tumor necrosis factor-α, IFN-γ, interferon-γ, DHE, dihydroethidine, Xanthine oxidase, IL-6, interleukin-6, NOS, nitric oxide synthase, chemistry.chemical_classification, Nox, NADPH oxidase, Ischemia-reperfusion, RBC, red blood cell, Duox, dual oxidase, IMAC, inner membrane anion channel, FAD, flavin adenine dinucleotide, Cell Hypoxia, Cell biology, iNOS, inducible nitric oxide synthase, NADPH, Nicotinamide adenine dinucleotide phosphate, UCP, uncoupling protein, AP-1, activator protein-1, MAO, monoamine oxidase, DPI, diphenyliodonium, CuZn SOD, copper–zinc superoxide dismutase, MPTP, mitochondrial permeability transition pore, H/R, hypoxia-reoxygenation, GAG, glycosaminoglycans, PKC, protein kinase C, Humans, PR-39, synthetic peptide inhibitor of Nox, XOR, xanthine oxidoreductase (XD+XO), PAF, platelet activating factor, NO, nitric oxide, NO2-, nitrite ion, XO, xanthine oxidase, NADPH oxidase, EC, endothelial cell, medicine.disease, HIF-1α, hypoxia inhibitory factor-1α, PDH, pyruvate dehydrogenase, XDH, xanthine dehydrogenase, DHFR, dihydrofolate reductase, mtROS, mitochondrial reactive oxygen species, chemistry, RET, reverse electron transport, mtNOS, mitochondrial nitric oxide synthase, α-GPD, α-glycerophosphate dehydrogenase, TCA, tricarboxyl acid, Reactive Oxygen Species, NNT, NADP-transhydrogenase, Clinical Biochemistry, A/R, anoxia-reoxygenation, ICAM-1, intercellular adhesion molecule-1, Mitochondrion, medicine.disease_cause, NFkB, nuclear factor kappa-B, RIRR, ROS-induced ROS release, chemistry.chemical_compound, Trx, thioredoxin, NAD+, Nicotinamide adenine dinucleotide (oxidized), GTPCH, guanosine triphosphate cyclohydrolase I, biology, GPx, glutathione peroxidase, eNOS, endothelial nitric oxide synthase, I/R, ischemia-reperfusion, DHR, dihyrdrorhodamine, Mitochondria, Nitric oxide synthase, ∆ψ, membrane potential, H2O2, hydrogen peroxide, Reperfusion Injury, ESR, electron spin resonance, Oxidation-Reduction, Research Paper, IL-1β, interleukin-1beta, FADH2, reduced FAD, α-KDH, α-ketoglutarate dehydrogenase, LTB4, leukotriene B4, ETC, electron transport chain, CoQ, coenzyme Q, ROS, reactive oxygen species, SOD, superoxide dismutase, medicine, Animals, MnSOD, manganese superoxide dismutase, O2·-, superoxide anion, Reactive oxygen species, Organic Chemistry, BH4, tetrahydrobiopterin, PEG-, polyethylene glycol conjugated, NADH, Nicotinamide adenine dinucleotide (reduced), Oxidative Stress, DCF, dichlorofluorescein, biology.protein, BM, bone marrow, Prx, peroxiredoxin, NAD+ kinase, Hypoxia-reoxygenation, Reperfusion injury, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3520729b589e969c5edc96b3d9b99Test
http://europepmc.org/articles/PMC4625011Test

المؤلفون: Angela J. Lamb, Roya S. Nazarian

المصدر: JAAD Case Reports
JAAD Case Reports, Vol 3, Iss 1, Pp 13-15 (2017)

مصطلحات موضوعية: Population, efficacy, Case Report, Dermatology, Pharmacology, methotrexate, 030207 dermatology & venereal diseases, 03 medical and health sciences, Folinic acid, folic acid, 0302 clinical medicine, Psoriasis, adalimumab, Dihydrofolate reductase, lcsh:Dermatology, medicine, 030212 general & internal medicine, education, education.field_of_study, drug interaction, biology, business.industry, L-methylfolate, Tetrahydrobiopterin, psoriasis, lcsh:RL1-803, medicine.disease, DHFR, dihydrofolate reductase, B vitamins, Methylenetetrahydrofolate reductase, biology.protein, Methotrexate, business, MTHFR, methylenetetrahydrofolate reductase, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec0a0de2dbb49094e2dc398593f8b1fTest

المؤلفون: Cornelis L. Verweij, G.J. Peters, Gerrit Jansen, Alexandre E. Voskuyl, Y. Gent, M. Blits, Karin Weijers, J.G.M. van der Heijden, Rik J. Scheper, W.F. Lems, Marjon Al, Carla F. M. Molthoff, B A C Dijkmans, Y. Aassaraf, J. van der Laken, Manohar Ratnam

المساهمون: Rheumatology, Pathology, Medical oncology laboratory, CCA - Immuno-pathogenesis, MOVE Research Institute, Radiology and nuclear medicine

المصدر: Pteridines, Vol 24, Iss 1, Pp 21-26 (2013)
Jansen, G, Weijers, K, Blits, M, van der Heijden, J, Gent, Y, Al, M C M, van der Laken, J, Molthoff, C F M, Verweij, C L, Voskuyl, A E, Lems, W F, Scheper, R J, Peters, G J, Ratnam, M, Aassaraf, Y & Dijkmans, B A C 2013, ' Folates and antifolates in rheumatoid arthritis ', Pteridines, vol. 24, no. 1, pp. 21-26 . https://doi.org/10.1515/pterid-2013-0012Test
Pteridines, 24(1), 21-26. International Society of Pteridinology

مصطلحات موضوعية: Oncology, musculoskeletal diseases, rheumatoid arthritis, medicine.medical_specialty, Clinical Biochemistry, Early detection, Arthritis, Biochemistry, Efficacy, chemistry.chemical_compound, Internal medicine, antifolates, medicine, skin and connective tissue diseases, Crystallography, Chemistry, Standard treatment, medicine.disease, Folate antagonist, folates, QD901-999, Rheumatoid arthritis, Antifolate, Molecular Medicine, Methotrexate, abbreviations and enzyme codes: atic/aicartf, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (ec 2.1.2.3), dhfr, dihydrofolate reductase (ec 1.5.1.3), fpgs, folylpolyglutamate synthetase (ec 6.3.2.17), frα/β, folate receptor alpha/beta, gart, glycinamideribonucleotide formyltransferase (ec 2.1.2.2), ggh/fpgh, gamma-glutamyl hydrolase/folylpolyglutamate hydrolyse (ec 3.4.19.9), mthfr, methylenetetrahydrofolate reductase (ec 1.5.1.20), mtx, methotrexate, pb, peripheral blood, pcft/slc46a1, proton-coupled folate transporter, pg, polyglutamates, rfc/slc19a1, reduced folate carrier, tyms, thymidylate synthase (ec 2.1.1.45), medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cead0c843641fd47e0d30ee170ebce2eTest
http://www.degruyter.com/view/j/pteridines.2013.24.issue-1/pterid-2013-0012/pterid-2013-0012.xmlTest

المؤلفون: Opladen, Thomas, Cortès-Saladelafont, Elisenda, Mastrangelo, Mario, Horvath, Gabriella, Pons, Roser, Lopez-Laso, Eduardo, Fernández-Ramos, Joaquín A., Honzik, Tomas, Pearson, Toni, Friedman, Jennifer, Scholl-Bürgi, Sabine, Wassenberg, Tessa, Jung-Klawitter, Sabine, Kuseyri, Oya, Jeltsch, Kathrin, Kurian, Manju A., Garcia-Cazorla, Àngels

المصدر: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, 9, pp. 61-66
Molecular Genetics and Metabolism Reports, 9, 61-66

مصطلحات موضوعية: PTPS, 6-pyruvoyl-tetrahydropterin synthase, SR, sepiapterin reductase, database, dopamine, GABA, glycine, guideline, network, neurotransmitter, patient registry, serine, serotonin, molecular biology, genetics, endocrinology, PSAT, phosphoserine aminotransferase, TH, tyrosine hydroxylase, SSADH, succinic semialdehyde dehydrogenase, 3-PGDH, 3-phosphoglycerat dehydrogenase, 3-PGH, 3-phosphoglycerat dehydrogenase, DHPR, dihydropteridine reductase, DAT, dopamine transporter, DßH, dopamine β-hydroxylase, 3-PSP, 3-phosphoserine phosphatase, NOS, nitric oxide synthase, AADC, aromatic l-amino acid decarboxylase, TPH, tryptophan hydroxylase, PAH, phenylalanine hydroxylase, DHFR, dihydrofolate reductase deficiency, BH4, tetrahydrobiopterin, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], NKH, nonketotic hyperglycinemia, GABA, gamma aminobutyric acid, FOLR1, folate receptor alpha, AR/ADGTPCH, autosomal recessive/dominant GTP-cyclohydrolase deficiency, VMAT, vesicular monoamine transporter, MAOA, monoamine oxidase A, 5-MTHF, 5-methyltetrahydrofolate, Research Paper

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8335a3ace41414b3965008b38d1135d5Test
http://hdl.handle.net/11573/955654Test