Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives
| العنوان: | Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives |
|---|---|
| المؤلفون: | Deidre M. Mattiske, Andrew J Pask |
| المصدر: | Current Research in Toxicology, Vol 2, Iss, Pp 179-191 (2021) Current Research in Toxicology |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | DHT, dihydrotestosterone, ER, estrogen receptor, Urethral closure, Health, Toxicology and Mutagenesis, NOAEL, no observed adverse effect level, EMT, epithelial to mesenchymal transition, PCB, polychlorinated biphenyl, DBP, Σdibutyl phthalate, Toxicology, Bioinformatics, DEHP, Σdi-2(ethylhexyl)-phthalate, Applied Microbiology and Biotechnology, Article, Androgen, PCE, tetrachloroethylene, RA1190-1270, medicine, DDT, dichlorodiphenyltrichloroethane, Endocrine system, Endocrine disruptors, ComputingMethodologies_COMPUTERGRAPHICS, Hypospadias, EDC, endocrine disrupting chemicals, GT, genital tubercle, PBDE, polybrominated diphenyl ether, business.industry, PBB, polybrominated biphenyl, medicine.disease, Estrogen, BPA, bisphenol A, medicine.anatomical_structure, Normal penis, BBP, benzyl butyl phthalate, Toxicology. Poisons, business, Penis |
| الوصف: | Graphical abstract Highlights • Penis development is regulated by a tight balance of androgens and estrogens. • EDCs that impact androgen/estrogen balance during development cause hypospadias. • Cross-disciplinary collaborations are needed to define a mechanistic link. Hypospadias is a defect in penile urethral closure that occurs in approximately 1/150 live male births in developed nations, making it one of the most common congenital abnormalities worldwide. Alarmingly, the frequency of hypospadias has increased rapidly over recent decades and is continuing to rise. Recent research reviewed herein suggests that the rise in hypospadias rates can be directly linked to our increasing exposure to endocrine disrupting chemicals (EDCs), especially those that affect estrogen and androgen signalling. Understanding the mechanistic links between endocrine disruptors and hypospadias requires toxicologists and developmental biologists to define exposures and biological impacts on penis development. In this review we examine recent insights from toxicological, developmental and epidemiological studies on the hormonal control of normal penis development and describe the rationale and evidence for EDC exposures that impact these pathways to cause hypospadias. Continued collaboration across these fields is imperative to understand the full impact of endocrine disrupting chemicals on the increasing rates of hypospadias. |
| تدمد: | 2666-027X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6a4feece5728c2a57646b8ca982bb7Test https://doi.org/10.1016/j.crtox.2021.03.004Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5e6a4feece5728c2a57646b8ca982bb7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2666027X |
|---|