المؤلفون: George, Kiran, Lopez-Mateos, Diego, El-Aziz, Tarek Mohamed Abd, Xiao, Yucheng, Kline, Jake, Bao, Hong, Raza, Syed, Stockand, James D, Cummins, Theodore R, Fornelli, Luca, Rowe, Matthew P, Yarov-Yarovoy, Vladimir, Rowe, Ashlee H

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Chronic Pain, Pain Research, 1.1 Normal biological development and functioning, Underpinning research, Nav1, 8, voltage-gated sodium channel, AZ bark scorpion, grasshopper mice, NaTx36, slow inactivation, venom, neurotoxin, Nav1.8, Pharmacology and Pharmaceutical Sciences, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5hc4788gTest

المؤلفون: Shin, Seung Min, Itson-Zoske, Brandon, Fan, Fan, Xiao, Yucheng, Qiu, Chensheng, Cummins, Theodore R, Hogan, Quinn H, Yu, Hongwei

المصدر: J Clin Invest ; ISSN:1558-8238

مصطلحات موضوعية: Gene therapy, Neuroscience, Pain, Sodium channels, Therapeutics

العلاقة: https://doi.org/10.1172/JCI170813Test; https://pubmed.ncbi.nlm.nih.gov/38722683Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213509Test/

الإتاحة: https://doi.org/10.1172/JCI170813Test
https://pubmed.ncbi.nlm.nih.gov/38722683Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213509Test/

المؤلفون: Zybura, Agnes S., Sahoo, Firoj K., Hudmon, Andy, Cummins, Theodore R.

المساهمون: Biology, School of Science

المصدر: PMC

مصطلحات موضوعية: CaMKII, Nav1.6, Phosphorylation, Sodium channel, Electrophysiology, Post-translational modification (PTM)

وصف الملف: application/pdf

العلاقة: Cells; Zybura AS, Sahoo FK, Hudmon A, Cummins TR. CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav1.6 Channels and Reduces Neuronal Excitability. Cells. 2022;11(13):2108. Published 2022 Jul 4. doi:10.3390/cells11132108; https://hdl.handle.net/1805/34452Test

الإتاحة: https://doi.org/10.3390/cells11132108Test
https://hdl.handle.net/1805/34452Test

المؤلفون: Xiao, Yucheng, Theile, Jonathan W., Zybura, Agnes, Pan, Yanling, Lin, Zhixin, Cummins, Theodore R.

المساهمون: Biology, School of Science

المصدر: PMC

مصطلحات موضوعية: Dorsal root ganglion, Neuroscience, Rat, Resurgent currents, Sodium channel

وصف الملف: application/pdf

العلاقة: eLife; Xiao Y, Theile JW, Zybura A, Pan Y, Lin Z, Cummins TR. A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels. Elife. 2022;11:e77558. Published 2022 Apr 20. doi:10.7554/eLife.77558; https://hdl.handle.net/1805/33981Test

الإتاحة: https://doi.org/10.7554/eLife.77558Test
https://hdl.handle.net/1805/33981Test

المؤلفون: Gomes, Cátia, VanderWall, Kirstin B., Pan, Yanling, Lu, Xiaoyu, Lavekar, Sailee S., Huang, Kang-Chieh, Fligor, Clarisse M., Harkin, Jade, Zhang, Chi, Cummins, Theodore R., Meyer, Jason S.

المساهمون: Medical and Molecular Genetics, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Stem cell, Retina, Retinal ganglion cell, Astrocyte, Neurodegeneration, Glaucoma, Autophagy

وصف الملف: application/pdf

العلاقة: Stem Cell Reports; Gomes C, VanderWall KB, Pan Y, et al. Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells. Stem Cell Reports. 2022;17(7):1636-1649. doi:10.1016/j.stemcr.2022.05.006; https://hdl.handle.net/1805/34579Test

الإتاحة: https://doi.org/10.1016/j.stemcr.2022.05.006Test
https://hdl.handle.net/1805/34579Test

المؤلفون: Milder, Patrick C., Zybura, Agnes S., Cummins, Theodore R., Marrs, James A.

المصدر: Frontiers in Pharmacology ; volume 13 ; ISSN 1663-9812

مصطلحات موضوعية: Pharmacology (medical), Pharmacology

الإتاحة: https://doi.org/10.3389/fphar.2022.836573Test

المؤلفون: El-Aziz, Tarek Mohamed Abd, Xiao, Yucheng, Kline, Jake, Gridley, Harold, Heaston, Alyse, Linse, Klaus D., Ward, Micaiah J., Rokyta, Darin R., Stockand, James D., Cummins, Theodore R., Fornelli, Luca, Rowe, Ashlee H.

المساهمون: Biology, School of Science

المصدر: PMC

مصطلحات موضوعية: Centruroides sculpturatus, Nav1.8, Onychomys torridus, Bioactive proteins, Drug discovery, Hyperpolarization, Neurotoxin, Pain signaling, Scorpion venom, Voltage-gated sodium channel

وصف الملف: application/pdf

العلاقة: Toxins; Abd El-Aziz TM, Xiao Y, Kline J, et al. Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling. Toxins (Basel). 2021;13(7):501. Published 2021 Jul 18. doi:10.3390/toxins13070501; https://hdl.handle.net/1805/31081Test

الإتاحة: https://doi.org/10.3390/toxins13070501Test
https://hdl.handle.net/1805/31081Test

المؤلفون: Zybura, Agnes, Hudmon, Andy, Cummins, Theodore R.

المساهمون: Biology, School of Science

المصدر: PMC

مصطلحات موضوعية: Voltage-gated sodium channel, Action potential, Axon initial segment, Sodium currents, Channelopathies, Post-translational modifications, Protein-protein interactions

وصف الملف: application/pdf

العلاقة: Cells; Zybura A, Hudmon A, Cummins TR. Distinctive Properties and Powerful Neuromodulation of Nav1.6 Sodium Channels Regulates Neuronal Excitability. Cells. 2021;10(7):1595. Published 2021 Jun 25. doi:10.3390/cells10071595; https://hdl.handle.net/1805/31025Test

الإتاحة: https://doi.org/10.3390/cells10071595Test
https://hdl.handle.net/1805/31025Test

المؤلفون: Brewer, Kathryn M., Bansal, Ruchi, Engle, Staci E., Antonellis, Patrick J., Cummins, Theodore R., Berbari, Nicolas F.

المساهمون: Biology, School of Science

المصدر: Publisher

مصطلحات موضوعية: Puberty, Reproduction, Gonadotrophins, Luteinizing hormones, Follicle stimulating hormones

وصف الملف: application/pdf

العلاقة: Journal of the Endocrine Society; Kathryn M Brewer, Ruchi Bansal, Staci E Engle, Patrick J Antonellis, Theodore R Cummins, Nicolas F Berbari, Polyciliation of GnRH Neurons in Vivo and in Vitro, Journal of the Endocrine Society, Volume 5, Issue Supplement_1, April-May 2021, Pages A548–A549, https://doi.org/10.1210/jendso/bvab048.1117Test; https://hdl.handle.net/1805/35605Test

الإتاحة: https://doi.org/10.1210/jendso/bvab048.1117Test
https://hdl.handle.net/1805/35605Test

المؤلفون: Pan, Yanling, Xiao, Yucheng, Pei, Zifan, Cummins, Theodore R.

المساهمون: Biology, School of Science

المصدر: PMC

مصطلحات موضوعية: Dorsal root ganglia, Neurological disorders, Neuronal excitability, Neurophysiology, Post-translational modification (PTM), Protein palmitoylation

وصف الملف: application/pdf

العلاقة: Journal of Biological Chemistry; Pan Y, Xiao Y, Pei Z, Cummins TR. S-Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability. J Biol Chem. 2020;295(18):6151-6164. doi:10.1074/jbc.RA119.012423; https://hdl.handle.net/1805/30058Test

الإتاحة: https://doi.org/10.1074/jbc.RA119.012423Test
https://hdl.handle.net/1805/30058Test