دورية أكاديمية
Surgery for IDH1/2 wild-type glioma invading the corpus callosum
| العنوان: | Surgery for IDH1/2 wild-type glioma invading the corpus callosum |
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| المؤلفون: | Heiland, Pamela, Delev, Daniel, Cipriani, Debora, Neidert, Nicolas, Kellner, Elias, Masalha, Waseem, Mercas, Bianca, Mader, Irina, Reinacher, Peter, Weyerbrock, Astrid, Fung, Christian, Beck, Jürgen, Heiland, Dieter Henrik, Schnell, Oliver |
| المصدر: | http://lobid.org/resources/99370675015906441Test#!, 163(4):937-945. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Glioma/surgery [MeSH], Aged [MeSH], Brain Neoplasms/surgery [MeSH], Postoperative Complications/epidemiology [MeSH], Tumor – Glioma, Original Article - Tumor - Glioma, Corpus Callosum/pathology [MeSH], Glioma/pathology [MeSH], Male [MeSH], Tumor Burden [MeSH], Corpus callosum glioblastoma, Karnofsky Performance Status [MeSH], IDH status, Female [MeSH], Brain Neoplasms/genetics [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Neurosurgery, Glioblastoma, Extent of resection, Neurosurgical Procedures/methods [MeSH], Corpus Callosum/surgery [MeSH], Molecular diagnosis, Glioma/genetics [MeSH], Neurosurgical Procedures/adverse effects [MeSH], Butterfly glioblastoma, Isocitrate Dehydrogenase/genetics [MeSH], Brain Neoplasms/pathology [MeSH] |
| الوصف: | Background!#!Glioblastoma of the corpus callosum (ccGBM) are rare tumors, with a dismal prognosis marked by a rapid clinical deterioration. For a long time, surgical treatment was not considered beneficial for most patients with such tumors. Recent studies claimed an improved survival for patients undergoing extensive resection, albeit without integration of the molecular profile of the lesions. The purpose of this study was to investigate the effect of biopsy and surgical resection on oncological and functional outcomes in patients with IDH wild-type ccGBM.!##!Methods!#!We performed a retrospective analysis of our institution's database of patients having been treated for high-grade glioma between 2005 and 2017. Inclusion criteria were defined as follows: patients older than 18 years, histopathological, and molecularly defined IDH wild-type glioma, major tumor mass (at least 2/3) invading the corpus callosum in the sagittal plane with a uni- or bilateral infiltration of the adjacent lobules. Surgical therapy (resection vs. biopsy), extent of resection according to the remaining tumor volume and adjuvant treatment as well as overall survival and functional outcome using the Karnofsky Performance Score (KPS) were analyzed.!##!Results!#!Fifty-five patients were included in the study, from which the mean age was 64 years and men (n = 34, 61.8%) were more often affected than women (n = 21, 38.2%). Thirty (54.5%) patients were treated with stereotactic biopsy alone, while 25 patients received tumor resection resulting in 14.5% (n = 8) gross-total resections and 30.9% (n = 17) partial resections. The 2-year survival rate after resection was 30% compared to 7% after biopsy (p = 0.047). The major benefit was achieved in the group with gross-total resection, while partial resection failed to improve survival. Neurological outcome measured by KPS did not differ between both groups either pre- or postoperatively.!##!Conclusions!#!Our study suggests that in patients with corpus callosum glioblastoma, gross-total resection ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6470366Test; https://doi.org/10.1007/s00701-020-04623-zTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966629Test/ |
| DOI: | 10.1007/s00701-020-04623-z |
| الإتاحة: | https://doi.org/10.1007/s00701-020-04623-zTest https://repository.publisso.de/resource/frl:6470366Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966629Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.B49E851B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00701-020-04623-z |
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