المؤلفون: Mark S. Forman, Peter Orth, Ulrich Iserloh, Yusheng Wu, Hongwu Wang, William J. Greenlee, Reshma Kuvelkar, Xia Chen, Jack D. Scott, John Meredith, Lana M. Rossiter, Lynn A. Hyde, Robert A. Hodgson, Andrew Stamford, Julie A. Stone, Irina Kazakevich, Ganfeng Wang, Eric M. Parker, Eric J. Gilbert, Kathleen Cox, Corey O. Strickland, Sarah W. Li, Meagan Slater, Qin Jiang, Johannes H. Voigt, Hong Mei, Andrew Brunskill, Matthew E. Kennedy, Misiaszek Jeffrey A, Jared N. Cumming

المصدر: Journal of Medicinal Chemistry. 59:10435-10450

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, High selectivity, Cathepsin D, Rats, Sprague-Dawley, Amyloid beta-Protein Precursor, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Aspartate protease, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, Animals, Humans, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Thiadiazines, biology, Cyclic S-Oxides, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, Biochemistry, chemistry, biology.protein, Molecular Medicine, Verubecestat, Clinical evaluation, Derivative (chemistry)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88617ac0382047768a81e118b787b6caTest
https://doi.org/10.1021/acs.jmedchem.6b00307Test

المؤلفون: Daniel F. Wyss, Jared N. Cumming, Corey O. Strickland, Andrew W. Stamford

مصطلحات موضوعية: 0301 basic medicine, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, 030104 developmental biology, 01 natural sciences, 0104 chemical sciences

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1be5ac203545431cb57e2301db9f9d36Test
https://doi.org/10.1002/9783527683604.ch14Test

المؤلفون: Peter Orth, Bandarpalle B. Shankar, Daniel Lundell, Corey O. Strickland, Vinay Girijavallabhan, Chaoyang Dai, Joseph A. Kozlowski, Janeta Popovici-Muller, Brian J. Lavey, Jing Sun, Shiying Chen, Dansu Li, John J. Piwinski, Razia Rizvi, M. Arshad Siddiqui, Kristin E. Rosner, Lianyun Zhao, Zhuyan Guo, Wong Michael K C, Neng-Yang Shih, Xiaoda Niu

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3172-3176

مصطلحات موضوعية: Pyrrolidines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Tartrate, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Oral administration, Amide, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Tartrates, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Amides, Rats, Enzyme Activation, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffe3fdf02a5dba0580b311b55f7fe2Test
https://doi.org/10.1016/j.bmcl.2011.01.002Test

المؤلفون: Jing Sun, Corey O. Strickland, John P. Caldwell, Kristin E. Rosner, Pauline C. Ting, Bandarpalle B. Shankar, Shiying Chen, David B. Belanger, Gerald W. Shipps, Vinay Girijavallabhan, Guowei Zhou, Brian J. Lavey, Dansu Li, Razia Rizvi, Peter Orth, Neng-Yang Shih, M. Arshad Siddiqui, Zhaoning Zhu, Wensheng Yu, Zhuyan Guo, Zhidan Liu, Maria David, John J. Piwinski, Daniel Lundell, Henry M. Vaccaro, Joe F. Lee, Jim Spitler, Vincent S. Madison, Xiaoda Niu, Chaoyang Dai, Mckittrick Brian A, Joseph A. Kozlowski, Janeta Popovici-Muller, Rob Mazzola

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4812-4815

مصطلحات موضوعية: Molecular model, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Tartrate, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Computer Simulation, Protease Inhibitors, Tartrates, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, In vitro, Rats, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b8670bf1029b4ff13b82406eff8483Test
https://doi.org/10.1016/j.bmcl.2010.06.104Test

المؤلفون: Piwinski John J, Corey O. Strickland, Jing Sun, Patrick J. Curran, Vinay Girijavallabhan, Zhuyan Guo, Li Wang, Shih Neng-Yang, Liwu Hong, Yongqi Deng, Pauline C. Ting, Daniel Lundell, Guowei Zhou, Gerald W. Shipps, Chan Tin Yau, Wensheng Yu, Zhidan Liu, Joe F. Lee, M. Arshad Siddiqui, Janeta Popovici-Muller, Xiaoda Niu, Brian J. Lavey, Vincent Madison, Tong Wang, Chaoyang Dai, Joseph A. Kozlowski, Mckittrick Brian A, Kristin E. Rosner, David B. Belanger, Vaccaro Henry A, Dansu Li, Peter Orth

المصدر: Bioorganicmedicinal chemistry letters. 20(3)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Tartrate, Matrix metalloproteinase, ADAM17 Protein, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Hydrolase, Drug Discovery, Combinatorial Chemistry Techniques, Humans, Protease Inhibitors, Molecular Biology, Tartrates, chemistry.chemical_classification, Binding Sites, biology, Tumor Necrosis Factor-alpha, Organic Chemistry, Active site, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Tartaric acid, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389e5b82ce82b8555a1543681cf0b86dTest
https://pubmed.ncbi.nlm.nih.gov/20022498Test

المؤلفون: Carolyn DiIanni Carroll, Babu Suresh D, Dawit Tadesse, Reshma Kuvelkar, Liyang Wang, Lili Zhang, Tao Guo, Yuhua Huang, Andrew Stamford, Matthew E. Kennedy, Doug W. Hobbs, Yusheng Wu, Corey O. Strickland, Leonard Favreau, Lynne E. Ozgur, Johannes H. Voigt, Ge Li, Le Thuy X H, Xia Chen, Ulrich Iserloh, J. Lowrie, P. Gaspari, Jared N. Cumming, Nansie A. McHugh, J. Pan, Kurt W. Saionz, Eric M. Parker, Qi Zhang

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4447

مصطلحات موضوعية: Imidazolidinone, Chemistry, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Rational design, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry, Combinatorial chemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4cef0a70927a03b7fb8482695c47b41eTest
https://doi.org/10.1016/j.bmcl.2008.06.022Test