دورية أكاديمية
Model discovery approach enables noninvasive measurement of intra-tumoral fluid transport in dynamic MRI
| العنوان: | Model discovery approach enables noninvasive measurement of intra-tumoral fluid transport in dynamic MRI |
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| المؤلفون: | Ryan T. Woodall, Cora C. Esparza, Margarita Gutova, Maosen Wang, Jessica J. Cunningham, Alexander B. Brummer, Caleb A. Stine, Christine C. Brown, Jennifer M. Munson, Russell C. Rockne |
| المصدر: | APL Bioengineering, Vol 8, Iss 2, Pp 026106-026106-12 (2024) |
| بيانات النشر: | AIP Publishing LLC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a routine method to noninvasively quantify perfusion dynamics in tissues. The standard practice for analyzing DCE-MRI data is to fit an ordinary differential equation to each voxel. Recent advances in data science provide an opportunity to move beyond existing methods to obtain more accurate measurements of fluid properties. Here, we developed a localized convolutional function regression that enables simultaneous measurement of interstitial fluid velocity, diffusion, and perfusion in 3D. We validated the method computationally and experimentally, demonstrating accurate measurement of fluid dynamics in situ and in vivo. Applying the method to human MRIs, we observed tissue-specific differences in fluid dynamics, with an increased fluid velocity in breast cancer as compared to brain cancer. Overall, our method represents an improved strategy for studying interstitial flows and interstitial transport in tumors and patients. We expect that our method will contribute to the better understanding of cancer progression and therapeutic response. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2473-2877 |
| العلاقة: | https://doaj.org/toc/2473-2877Test |
| DOI: | 10.1063/5.0190561 |
| الوصول الحر: | https://doaj.org/article/dce02c765ce54dfa9ebc85c9d1da3e4bTest |
| رقم الانضمام: | edsdoj.02c765ce54dfa9ebc85c9d1da3e4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24732877 |
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| DOI: | 10.1063/5.0190561 |