The biobehavioral Women’s Health CoOp in Pretoria, South Africa: study protocol for a cluster-randomized design

التفاصيل البيبلوغرافية
العنوان: The biobehavioral Women’s Health CoOp in Pretoria, South Africa: study protocol for a cluster-randomized design
المؤلفون: William A. Zule, Nathaniel Rodman, Jacqueline Wanjiku Ndirangu, Tracy Kline, Charles van der Horst, Wendee M. Wechsberg, Scott P. Novak, Irene A. Doherty
المصدر: BMC Public Health
بيانات النشر: Springer Science and Business Media LLC, 2014.
سنة النشر: 2014
مصطلحات موضوعية: Safe Sex, Gerontology, Psychological intervention, HIV Infections, law.invention, Study Protocol, South Africa, 0302 clinical medicine, Randomized controlled trial, Pregnancy, law, Mass Screening, Medicine, Prospective Studies, 030212 general & internal medicine, education.field_of_study, Incidence, 1. No poverty, virus diseases, Seek, test, treat and retain paradigm, Vulnerable women, 3. Good health, Female, 0305 other medical science, Adult, medicine.medical_specialty, Women’s Health CoOp, Adolescent, Substance-Related Disorders, Population, Black People, Vulnerable Populations, Young Adult, 03 medical and health sciences, Risk-Taking, Condom, Intervention (counseling), Humans, Healthcare Disparities, education, Mass screening, Combined biobehavioral intervention, 030505 public health, business.industry, Public health, Public Health, Environmental and Occupational Health, HIV, Health Status Disparities, Quality of Life, Women's Health, Cluster-randomized design, Biostatistics, business, Risk Reduction Behavior
الوصف: South Africa has 6.4 million adults over the age of 15 living with HIV. Gender inequality issues continue to drive the HIV epidemic in South Africa, where Black African women bear the greatest HIV burden. Limited access to services; little capacity to negotiate sex and condom use; and other legal, social, and economic inequities make women highly vulnerable to HIV infection. Behavioral interventions have been shown to decrease risk behaviors, but they have been less successful in reducing HIV incidence. Conversely, biomedical prevention strategies have proven to be successful in reducing HIV incidence, but require behavioral interventions to increase uptake and adherence. Consequently, there is a need for integrated approaches that combine biomedical and behavioral interventions. Effective combination prevention efforts should comprise biomedical, behavioral, and structural programming proven in randomized trials that focuses on the driving forces and key populations at higher risk of HIV infection and transmission. This prospective, geographically clustered randomized field experiment is enrolling participants into two arms: a control arm that receives standard HIV testing and referral for treatment; and an intervention arm that receives an evidence-based, woman-focused behavioral intervention that emphasizes risk reduction and retention, the Women’s Health CoOp. We divided the city of Pretoria into 14 mutually exclusive geographic zones and randomized these zones into either the control arm or the intervention arm. Outreach workers are recruiting drug-using women from each zone. At baseline, eligible participants complete a questionnaire and biological testing for HIV, recent drug use, and pregnancy. Follow-up interviews are completed at 6 and 12 months. The biobehavioral intervention in this study merges an efficacious behavioral HIV prevention intervention for women with biomedical prevention through HIV treatment as prevention using a Seek, Test, Treat and Retain strategy. This combination biobehavioral intervention is designed to (1) improve the quality of life and reduce HIV infectiousness among women who are HIV positive, and (2) reduce HIV risk behaviors among women regardless of their HIV status. If efficacious, this intervention could help control the HIV epidemic in South Africa. Trial registration no: NCT01497405 .
تدمد: 1471-2458
0149-7405
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e55b0ed680d2929db661b8d753b9017Test
https://doi.org/10.1186/1471-2458-14-1074Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....1e55b0ed680d2929db661b8d753b9017
قاعدة البيانات: OpenAIRE