المؤلفون: Hawtin, Stuart, André, Cédric, Collignon-Zipfel, Géraldine, Appenzeller, Simone, Bannert, Bettina, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Brunner, Hermine I., Ceci, Melanie, Deane, Jonathan, Feifel, Roland, Ferrero, Enrico, Kyburz, Diego, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Michellys, Pierre, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, Rush, James S., Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas, Junt, Tobias

المساهمون: Novartis

المصدر: Cell Reports Medicine ; volume 4, issue 5, page 101036 ; ISSN 2666-3791

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.xcrm.2023.101036Test
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/plainTest

المؤلفون: Hawtin, Stuart, Andre, Cedric Bernard, Collignon Zipfel, Geraldine, Appenzeller, Simone, Bettina, Bannert, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Hermine, Brunner, Ceci, Melanie, Jonathan, Deane, Feifel, Roland, Ferrero, Enrico, Diego, Kyburz, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Pierre, Michellys, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, James, Rush, Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas, Junt, Tobias

العلاقة: Hawtin, Stuart, Andre, Cedric Bernard, Collignon Zipfel, Geraldine, Appenzeller, Simone, Bettina, Bannert, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Hermine, Brunner, Ceci, Melanie, Jonathan, Deane, Feifel, Roland, Ferrero, Enrico, Diego, Kyburz, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Pierre, Michellys, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, James, Rush, Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas and Junt, Tobias (2023) Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy. Cell reports. Medicine, 4 (5). p. 101036. ISSN 2666-3791

الإتاحة: https://doi.org/10.1016/j.xcrm.2023.101036Test
https://oak.novartis.com/48150Test/
https://www.sciencedirect.com/science/article/pii/S2666379123001507?via%3DihubTest

المؤلفون: Hoyler, Thomas, Bannert, Bettina, Beck, Damian, Boulay, Thomas, Buffet, David, Caesar, Nadja, Calzascia, Thomas, Dawson King, Janet, Kyburz, Diego, Hennze, Robert, Huppertz, Christine, Littlewood-Evans, Amanda, Loetscher, Pius, Mertz, Kirsten D., Niwa, Satoru, Robert, Gautier, Rush, James, Sarret, Sophie, Stein, Thomas, Touil, Ismahane, Wieczorek, Grazyna, Collignon Zipfel, Geraldine, Hawtin, Stuart, Junt, Tobias

العلاقة: Hoyler, Thomas, Bannert, Bettina, Beck, Damian, Boulay, Thomas, Buffet, David, Caesar, Nadja, Calzascia, Thomas, Dawson King, Janet, Kyburz, Diego, Hennze, Robert, Huppertz, Christine, Littlewood-Evans, Amanda, Loetscher, Pius, Mertz, Kirsten D., Niwa, Satoru, Robert, Gautier, Rush, James, Sarret, Sophie, Stein, Thomas, Touil, Ismahane, Wieczorek, Grazyna, Collignon Zipfel, Geraldine, Hawtin, Stuart and Junt, Tobias (2022) Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants. JCI insight, 7 (13). ISSN 2379-3708

الإتاحة: https://doi.org/10.1172/jci.insight.149825Test
https://oak.novartis.com/47183Test/
https://insight.jci.orgTest/

المؤلفون: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland, Knoepfel, Thomas

العلاقة: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland and Knoepfel, Thomas (2022) Structure-based optimization of a fragment like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00696Test
https://oak.novartis.com/46530Test/

المؤلفون: Alper, Phillip, Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Geraldine, Gordon, William, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, Mckeever, Una, Michellys, Pierre, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James, Syka, Peter, Zhang, Yi, Zhu, Xuefeng

العلاقة: Alper, Phillip, Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Geraldine, Gordon, William, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, Mckeever, Una, Michellys, Pierre, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James, Syka, Peter, Zhang, Yi and Zhu, Xuefeng (2020) Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorganic and Medicinal Chemistry Letters, 30 (17). p. 127366. ISSN 14643405

الإتاحة: https://doi.org/10.1016/j.bmcl.2020.127366Test
https://oak.novartis.com/42543Test/
https://reader.elsevier.com/reader/sd/pii/S0960894X20304777?token=64ACE614744B89DB15C45049D71E6C1FEF8E0DBC0EE7CB21920A18D2A92618723FD2A453DAA07CF11C32FEA6E1EEDD5ETest

المؤلفون: Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland, Betschart, Claudia

العلاقة: Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland and Betschart, Claudia (2020) Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists using a Biochemical TLR8 Antagonist Competition Assay. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c00130Test
https://oak.novartis.com/41810Test/

المؤلفون: Alper, Phil B., Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Géraldine, Gordon, Perry, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, McKeever, Una, Michellys, Pierre-Yves, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James S., Syka, Peter, Zhang, Yi, Zhu, Xuefeng

المصدر: Bioorganic & Medicinal Chemistry Letters ; volume 30, issue 17, page 127366 ; ISSN 0960-894X

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Biology, Molecular Medicine, Biochemistry

الإتاحة: https://doi.org/10.1016/j.bmcl.2020.127366Test
https://api.elsevier.com/content/article/PII:S0960894X20304777?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0960894X20304777?httpAccept=text/plainTest