دورية أكاديمية
Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
| العنوان: | Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells |
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| المؤلفون: | Colucci, Manuel, Zumerle, Sara, Bressan, Silvia, Gianfanti, Federico, Troiani, Martina, Valdata, Aurora, D’Ambrosio, Mariantonietta, Pasquini, Emiliano, Varesi, Angelica, Cogo, Francesca, Mosole, Simone, Dongilli, Cristina, Desbats, Maria Andrea, Contu, Liliana, Revankdar, Ajinkya, Chen, Jingjing, Kalathur, Madhuri, Perciato, Maria Luna, Basilotta, Rossella, Laczko, Endre, Schauer, Stefan, Othman, Alaa, id_orcid:0 000-0002-0092-5594 |
| المصدر: | Cancer Cell, 42 (4) |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2024 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | senescence, prostate cancer, SASP, immunotherapy, RAR, adapalene, AP-1, metabolism, NK-Killing, allogenic infusion |
| الوصف: | Cellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SASP), released by senescent cells, plays a crucial role in this dichotomy. Consequently, the clinical challenge lies in developing therapies that safely enhance senescence in cancer, favoring tumor-suppressive SASP factors over tumor-promoting ones. Here, we identify the retinoic-acid-receptor (RAR) agonist adapalene as an effective pro-senescence compound in prostate cancer (PCa). Reactivation of RARs triggers a robust senescence response and a tumor-suppressive SASP. In preclinical mouse models of PCa, the combination of adapalene and docetaxel promotes a tumor-suppressive SASP that enhances natural killer (NK) cell-mediated tumor clearance more effectively than either agent alone. This approach increases the efficacy of the allogenic infusion of human NK cells in mice injected with human PCa cells, suggesting an alternative therapeutic strategy to stimulate the anti-tumor immune response in “immunologically cold” tumors. ; ISSN:1535-6108 ; ISSN:1878-3686 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/20.500.11850/668544Test |
| DOI: | 10.3929/ethz-b-000668544 |
| الإتاحة: | https://doi.org/20.500.11850/668544Test https://doi.org/10.3929/ethz-b-000668544Test https://doi.org/10.1016/j.ccell.2024.02.004Test https://hdl.handle.net/20.500.11850/668544Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc/4.0Test/ ; Creative Commons Attribution-NonCommercial 4.0 International |
| رقم الانضمام: | edsbas.624C2AD4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000668544 |
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