المؤلفون: Abid Ullah, Shujaat Ahmad, Niaz Ali, Haya Hussain, Mamdouh Allahyani, Mazen Almehmadi, Ahad Amer Alsaiari, Osama Abdulaziz, Feras Almarshad, Syeda Hajira Bukhari

المصدر: Diagnostics; Volume 13; Issue 7; Pages: 1234

مصطلحات موضوعية: moxifloxacin, gemifloxacin, QT prolongation, QRS-widening effect, healthy volunteers, Clinical Trial Phase 1

وصف الملف: application/pdf

العلاقة: Pathology and Molecular Diagnostics; https://dx.doi.org/10.3390/diagnostics13071234Test

الإتاحة: https://doi.org/10.3390/diagnostics13071234Test

المؤلفون: Yamamoto, Noboru, Satouchi, Miyako, Doi, Toshihiko, Fujiwara, Yutaka, Yanagitani, Noriko, Kawa, Yoshitaka, Yoh, Kiyotaka, Leopold, Lance, Munteanu, Mihaela, Sawada, Takashi, Han, Shirong, Noguchi, Kazuo, Nishio, Makoto

المصدر: Invest New Drugs ; ISSN:1573-0646 ; Volume:42 ; Issue:3

مصطلحات موضوعية: Clinical trial, phase 1, Indoleamine 2,3-dioxygenase, Non‒small-cell lung cancer, Pembrolizumab

العلاقة: https://doi.org/10.1007/s10637-024-01422-6Test; https://pubmed.ncbi.nlm.nih.gov/38530565Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164788Test/

الإتاحة: https://doi.org/10.1007/s10637-024-01422-6Test
https://pubmed.ncbi.nlm.nih.gov/38530565Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164788Test/

المؤلفون: Ben Tran, Richard D. Carvajal, Aurelien Marabelle, Sandip Pravin Patel, Patricia M. LoRusso, Erik Rasmussen, Gloria Juan, Vijay V. Upreti, Courtney Beers, Gataree Ngarmchamnanrith, Patrick Schöffski

المصدر: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-9 (2018)

مصطلحات موضوعية: Glucocorticoid-induced TNFR-related protein, Antibodies, monoclonal, Clinical trial, phase 1, Dose, maximum tolerated, Agonistic antibody, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s40425-018-0407-xTest; https://doaj.org/toc/2051-1426Test

الوصول الحر: https://doaj.org/article/c2fbc142a7e5490699bc7de71158c8cbTest

المؤلفون: Saskia Koene, Edwin Spaans, Luc Van Bortel, Griet Van Lancker, Brant Delafontaine, Fabio Badilini, Julien Beyrath, Jan Smeitink

المصدر: Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-12 (2017)

مصطلحات موضوعية: Randomized controlled trial, Mitochondrial medicine, Clinical trial phase 1, Mitochondrial disorder, Orphan drugs, Rare disease, Medicine

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13023-017-0715-0Test; https://doaj.org/toc/1750-1172Test

الوصول الحر: https://doaj.org/article/09fd79f686f64b96977b623d3acbd830Test

المؤلفون: Patrick Schöffski, Sandip Pravin Patel, Courtney Beers, Ben Tran, Richard D. Carvajal, Patricia LoRusso, Vijay V. Upreti, Erik Rasmussen, Gloria Juan, Aurélien Marabelle, Gataree Ngarmchamnanrith

المصدر: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-9 (2018)

مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, MELANOMA, Pharmacology, Agonistic antibody, ACTIVATION, maximum tolerated, 0302 clinical medicine, Immunophenotyping, Antineoplastic Agents, Immunological, Planned Dose, Neoplasms, Immunology and Allergy, Glucocorticoid-induced TNFR-related protein, Antibodies, monoclonal, Aged, 80 and over, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, CANCER, FAMILY, Clinical trial, Phenotype, Oncology, Dose, 030220 oncology & carcinogenesis, Monoclonal, Molecular Medicine, Female, Life Sciences & Biomedicine, Glucocorticoid, Hypophosphatemia, Dose, maximum tolerated, medicine.drug, Agonist, medicine.drug_class, Immunology, monoclonal, lcsh:RC254-282, Antibodies, 03 medical and health sciences, Pharmacokinetics, Clinical trial, phase 1, Cell Line, Tumor, Glucocorticoid-Induced TNFR-Related Protein, medicine, Humans, REGULATORY T-CELLS, GITR, IMMUNOTHERAPY, Glucocorticoids, Aged, Neoplasm Staging, Science & Technology, IDENTIFICATION, business.industry, medicine.disease, 030104 developmental biology, phase 1, Pharmacodynamics, LIGAND, business, Biomarkers, GENERATION

وصف الملف: Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9f62f8ee71a1a364d9591f41e7da8cTest
https://pubmed.ncbi.nlm.nih.gov/30253804Test

المؤلفون: Fabio Badilini, Lucas Van Bortel, Brant Delafontaine, Saskia Koene, Griet Van Lancker, Edwin Spaans, Jan A.M. Smeitink, Julien Beyrath

المصدر: Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-12 (2017)
Orphanet Journal of Rare Diseases, 12, 1, pp. 163
Orphanet Journal of Rare Diseases, 12, 163
Orphanet Journal of Rare Diseases
ORPHANET JOURNAL OF RARE DISEASES

مصطلحات موضوعية: Male, 0301 basic medicine, Mitochondrial Diseases, lcsh:Medicine, Phases of clinical research, Pharmacology, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Mitochondrial medicine, Medicine and Health Sciences, Medicine, Pharmacology (medical), KH176, Genetics (clinical), Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6], General Medicine, Middle Aged, Mitochondrial disorder, Clinical trial, Tolerability, Safety, Adult, Adolescent, DISORDERS, NUCLEAR, Placebo, QT interval, Redox, Young Adult, 03 medical and health sciences, Rare Diseases, Double-Blind Method, Pharmacokinetics, Cardiac conduction, Heart rate, INTERVAL, Humans, Orphan drugs, Dose-Response Relationship, Drug, business.industry, Research, Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6], lcsh:R, GLUTATHIONE DEFICIENCY, 030104 developmental biology, phase 1, Clinical trial phase 1, business, Rare disease, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6def6070fe39a944df84132e495d487aTest
https://doi.org/10.1186/s13023-017-0715-0Test

المؤلفون: Janssen Pharmaceutica N.V., Belgium

المصدر: An Open-label, Phase I Study to Determine the Safety and Pharmacokinetics of JNJ-26483327, a Multi-targeted Kinase Inhibitor, Administered to Subjects With Advanced Stage and/or Refractory Solid Malignancies

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00676299Test

المؤلفون: Mark T. Reding, J. C. Lin, Jerry S. Powell, L. A. Michaels, A. Shah, T. E. Coyle

المصدر: Journal of Thrombosis and Haemostasis

مصطلحات موضوعية: Adult, Male, Treatment outcome, Pharmacology, Hemophilia A, recombinant proteins, Recombinant factor viii, Polyethylene Glycols, Clinical Haemostasis and Thrombosis, law.invention, Young Adult, chemistry.chemical_compound, law, hemic and lymphatic diseases, Animals, Humans, Medicine, Prospective Studies, Factor VIII, business.industry, Half-life, Hematology, Middle Aged, Virology, Peptide Fragments, Phase i study, Treatment Outcome, Multicenter study, chemistry, Recombinant DNA, clinical trial, Phase 1, Original Article, business, pharmacokinetics, Bay, Ethylene glycol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f33e34c7556f0941fc2a69cf8eef7c1Test
https://doi.org/10.1111/jth.12506Test

المؤلفون: Takatoshi Takubo, Elwyn Loh, Kazuhiro Shibayama, Nozomu Fuse, Junichiro Watanabe, Takayuki Yoshino, Nobuyuki Yamamoto, Satoru Otani, Toshihiko Doi, Atsushi Ohtsu, Narikazu Boku, Haruyasu Murakami

المصدر: Cancer Chemotherapy and Pharmacology

مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, medicine.drug_class, Antineoplastic Agents, Insulin-Like Growth Factor Receptor, Antibodies, Monoclonal, Humanized, Toxicology, Monoclonal antibody, Receptor, IGF Type 1, Asian People, Japan, Clinical trial, phase 1, Neoplasms, Internal medicine, medicine, Humans, Pharmacology (medical), Insulin-Like Growth Factor I, Ganitumab, Receptor, Aged, Insulin-like growth factor 1 receptor, Pharmacology, Dose-Response Relationship, Drug, biology, business.industry, Antibodies, Monoclonal, Middle Aged, Gemcitabine, Insulin-Like Growth Factor Binding Protein 3, Treatment Outcome, Endocrinology, Oncology, Tolerability, Insulin-like growth factor receptor type 1, Monoclonal, Cancer research, biology.protein, Female, Original Article, Antibody, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1df4784157c8399ddd9fc6f02296069Test
https://doi.org/10.1007/s00280-012-1924-9Test

المؤلفون: Makoto Tahara, Takayuki Yoshino, Nozomu Fuse, Toshihiko Doi, Kazuhiro Shibayama, Atsushi Ohtsu, Takatoshi Takubo, David M. Weinreich

المصدر: Cancer Chemotherapy and Pharmacology

مصطلحات موضوعية: Adult, Male, Oncology, medicine.medical_specialty, Cancer Research, Angiogenesis, Recombinant Fusion Proteins, Antineoplastic Agents, Pharmacology, Toxicology, Angiopoietin-2, Cohort Studies, Japan, Pharmacokinetics, Clinical trial, phase 1, Neoplasms, Internal medicine, Angiopoietin-1, Dose escalation, medicine, Humans, Pharmacology (medical), Infusions, Intravenous, Trebananib, Aged, Antitumor activity, Dose-Response Relationship, Drug, business.industry, AMG 386, Antagonist, Middle Aged, Angiopoietin 1/2-neutralizing peptibody, Treatment Outcome, Tolerability, Original Article, Female, Safety, business, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13e53318a7907a1f6d6186edc2ff32dTest