المؤلفون: Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C. Haigis, Wolfgang Sippl, Dante Rotili, Antonello Mai, Clemens Steegborn

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, yielded four first, two top compounds, mammalian sirtuin 4, highly isoform selective, focused screen based, cellular activity sirtuins, acyl peptide substrate, optimization toward sirt4, implicating sirt4 ’, selective sirt4 inhibitors, specific inhibitors useful, potential therapeutic target, specific inhibitors, potential therapeutics, molecule inhibitors, specific small, testing hits, related diseases, metabolic diseases, mechanistic insights

العلاقة: https://figshare.com/articles/journal_contribution/Specific_Inhibitors_of_Mitochondrial_Deacylase_Sirtuin_4_Endowed_with_Cellular_Activity/25043979Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01496.s002Test
https://figshare.com/articles/journal_contribution/Specific_Inhibitors_of_Mitochondrial_Deacylase_Sirtuin_4_Endowed_with_Cellular_Activity/25043979Test

المؤلفون: Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W. Myers, David J. Huggins, Clemens Steegborn, Ileana C. Miranda, Peter T. Meinke, Jochen Buck, Lonny R. Levin

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/95c1debb563241228352ba4e29c74a64Test

المؤلفون: Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck

المصدر: Frontiers in Physiology, Vol 14 (2023)

مصطلحات موضوعية: soluble adenylyl cyclase, male contraceptive, residence time, drug development, picomolar potency, binding kinetics, Physiology, QP1-981

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphys.2023.1163389/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/4e985b67c0f441afacd084154e3cbd87Test

المؤلفون: Ramona S. Adolph, Eileen Beck, Kristian Schweimer, Andrea Di Fonzo, Michael Weyand, Paul Rösch, Birgitta M. Wöhrl, Clemens Steegborn

المصدر: Life; Volume 13; Issue 4; Pages: 949

مصطلحات موضوعية: deacetylase, HIV, Sirt1, regulation, crystal structure

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Biochemistry, Biophysics and Computational Biology; https://dx.doi.org/10.3390/life13040949Test

الإتاحة: https://doi.org/10.3390/life13040949Test

المؤلفون: Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck

المصدر: Frontiers in Physiology, Vol 13 (2022)

مصطلحات موضوعية: soluble adenylyl cyclase, male contraceptive, residence time, drug development, picomolar potency, binding kinetics, Physiology, QP1-981

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphys.2022.1013845/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/79059c54d75b4a94ab021be7ad8ea4dfTest

المؤلفون: Sandra Weiss, Ramona S. Adolph, Kristian Schweimer, Andrea DiFonzo, Marat Meleshin, Mike Schutkowski, Clemens Steegborn

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12764

مصطلحات موضوعية: activator, deacetylase, Sirt1, inhibitor, regulation

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Biochemistry; https://dx.doi.org/10.3390/ijms232112764Test

الإتاحة: https://doi.org/10.3390/ijms232112764Test

المؤلفون: Alfonso Rodriguez-Ruiz, Doreen Braun, Simon Pflug, Alexander Brol, Marc Sylvester, Clemens Steegborn, Ulrich Schweizer

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5361

مصطلحات موضوعية: selenoprotein, selenocysteine, thyroid hormone, kinetic analysis, mass spectrometry

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Endocrinology and Metabolism; https://dx.doi.org/10.3390/ijms23105361Test

الإتاحة: https://doi.org/10.3390/ijms23105361Test

المؤلفون: Shan Sun, Makoto Fushimi, Thomas Rossetti, Navpreet Kaur, Jacob Ferreira, Michael Miller, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Lonny R. Levin, Jochen Buck, Robert W. Myers, Stacia Kargman, Nigel Liverton, Peter T. Meinke, David J. Huggins

المصدر: Journal of Chemical Information and Modeling. 63:2828-2841

مصطلحات موضوعية: General Chemical Engineering, General Chemistry, Library and Information Sciences, Computer Science Applications

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fb83927e0a111c0e0b71b25f5a63223dTest
https://doi.org/10.1021/acs.jcim.2c01577Test

المؤلفون: Benjamin Suenkel, Sergio Valente, Clemens Zwergel, Sandra Weiss, Elisabetta Di Bello, Rossella Fioravanti, Michele Aventaggiato, João A. Amorim, Neha Garg, Surinder Kumar, David B. Lombard, Tuo Hu, Pankaj K. Singh, Marco Tafani, Carlos M. Palmeira, David Sinclair, Antonello Mai, Clemens Steegborn

المصدر: Journal of medicinal chemistry. 65(20)

مصطلحات موضوعية: Sirtuin 1, Sirtuin 3, Drug Discovery, Molecular Medicine, Humans, Sirtuins, Protein Isoforms, NAD, Peptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afd0c8aa27ecec7cea363831015b0c9Test
https://pubmed.ncbi.nlm.nih.gov/36228194Test

المؤلفون: Makoto Fushimi (1714441), Hannes Buck (11133216), Melanie Balbach (3354395), Anna Gorovyy (11133219), Jacob Ferreira (11133222), Thomas Rossetti (11133225), Navpreet Kaur (3162048), Lonny R. Levin (7818410), Jochen Buck (53581), Jonathan Quast (11133228), Joop van den Heuvel (192614), Clemens Steegborn (117996), Efrat Finkin-Groner (2013025), Stacia Kargman (1436677), Mayako Michino (1533277), Michael A. Foley (1289370), Michael Miller (821), Nigel J. Liverton (1834777), David J. Huggins (243837), Peter T. Meinke (1730713)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Cancer, Hematology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, TDI -10229, exhibits mouse pharmacokinetic prop., sAC inhibitors, displays nanomolar inhibition, sAC inhibition, vivo tool compound, Orally Bioavailable Inhibitor, vivo interrogation, ADCY, Soluble Adenylyl Cyclase

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_of_TDI-10229_A_Potent_and_Orally_Bioavailable_Inhibitor_of_Soluble_Adenylyl_Cyclase_sAC_ADCY10_/14981295Test

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00273.s001Test