المؤلفون: Leurs, Ulrike, Klein, Anders B, McSpadden, Ethan D, Griem-Krey, Nane, Solbak, Sara MØ, Houlton, Josh, Villumsen, Inge S, Vogensen, Stine B, Hamborg, Louise, Gauger, Stine J, Palmelund, Line B, Larsen, Anne Sofie G, Shehata, Mohamed A, Kelstrup, Christian D, Olsen, Jesper V, Bach, Anders, Burnie, Robert O, Kerr, D Steven, Gowing, Emma K, Teurlings, Selina MW, C., Chris, Gee, Christine L, Frølund, Bente, Kornum, Birgitte R, van Woerden, Geeske M, Clausen, Rasmus P, Kuriyan, John, Clarkson, Andrew N, Wellendorph, Petrine

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 118(31)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Brain Disorders, Neurosciences, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Binding Sites, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Carboxylic Acids, Crystallography, X-Ray, Cyclopentanes, Gene Expression Regulation, Enzymologic, HEK293 Cells, Humans, Neuroprotection, Protein Binding, Protein Domains, Signal Transduction, Sodium Oxybate, photoaffinity labeling, x-ray crystallography, HOCPCA, excitotoxicity, photothrombotic storke, photothrombotic stroke

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6fq63908Test
https://escholarship.org/content/qt6fq63908/qt6fq63908.pdfTest

المؤلفون: Zhao, Fabao, Atxabal, Unai, Mariottini, Sofia, Yi, Feng, Lotti, James S., Rouzbeh, Nirvan, Liu, Na, Bunch, Lennart, Hansen, Kasper B., Clausen, Rasmus P.

المصدر: Zhao , F , Atxabal , U , Mariottini , S , Yi , F , Lotti , J S , Rouzbeh , N , Liu , N , Bunch , L , Hansen , K B & Clausen , R P 2022 , ' Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity ' , Journal of Medicinal Chemistry , vol. 65 , no. 1 , pp. 734-746 . https://doi.org/10.1021/acs.jmedchem.1c01810Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01810Test
https://curis.ku.dk/portal/da/publications/derivatives-of-r35furanylcarboxamido2aminopropanoic-acid-as-potent-nmda-receptor-glycine-site-agonists-with-glun2-subunitspecific-activityTest(736150fc-2163-4ca7-9229-45de9ebebbc6).html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437973/pdf/nihms-1832808.pdfTest

المؤلفون: Zhao, Fabao, Mazis, Georgios, Yi, Feng, Lotti, James S., Layeux, Michael S., Schultz, Eric P., Bunch, Lennart, Hansen, Kasper B., Clausen, Rasmus P.

المصدر: Zhao , F , Mazis , G , Yi , F , Lotti , J S , Layeux , M S , Schultz , E P , Bunch , L , Hansen , K B & Clausen , R P 2022 , ' Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity ' , Frontiers in Chemistry , vol. 10 , 1008233 . https://doi.org/10.3389/fchem.2022.1008233Test

مصطلحات موضوعية: co-agonist, ionotropic glutamate receptors, ligand-gated ion channel, subtype selectivity, two-electrode voltage-clamp electrophysiology

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.3389/fchem.2022.1008233Test
https://curis.ku.dk/portal/da/publications/discovery-of-r2amino3triazolpropanoic-acid-derivatives-as-nmda-receptor-glycine-site-agonists-with-glun2-subunitspecific-activityTest(6e827a97-99ed-4d2d-885d-ac2ef9259f33).html
https://curis.ku.dk/ws/files/329206997/fchem_10_1008233.pdfTest

المؤلفون: Maolanon, Alex, Papangelis, Athanasios, Kawiecki, David, Mou, Tung Chung, Syrenne, Jed T., Yi, Feng, Hansen, Kasper B., Clausen, Rasmus P.

المصدر: Maolanon , A , Papangelis , A , Kawiecki , D , Mou , T C , Syrenne , J T , Yi , F , Hansen , K B & Clausen , R P 2021 , ' Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists ' , European Journal of Medicinal Chemistry , vol. 212 , 113099 . https://doi.org/10.1016/j.ejmech.2020.113099Test

مصطلحات موضوعية: (carboxycyclopropyl)glycine, NMDA, Synthesis, X-ray crystallography

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.ejmech.2020.113099Test
https://curis.ku.dk/portal/da/publications/stereoselective-synthesis-of-novel-2sccgiv-analogues-as-potent-nmda-receptor-agonistsTest(6a032034-8677-45d6-a5bd-d570da0063c2).html
https://curis.ku.dk/ws/files/332600413/1_s2.0_S0223523420310710_am.pdfTest

المؤلفون: Lie, Maria E.K., Kickinger, Stefanie, Skovgaard-Petersen, Jonas, Ecker, Gerhard F., Clausen, Rasmus P., Schousboe, Arne, White, H. Steve, Wellendorph, Petrine

المصدر: Lie , M E K , Kickinger , S , Skovgaard-Petersen , J , Ecker , G F , Clausen , R P , Schousboe , A , White , H S & Wellendorph , P 2020 , ' Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects ' , Neurochemical Research , vol. 45 , pp. 1551–1565 . https://doi.org/10.1007/s11064-020-03017-yTest

مصطلحات موضوعية: Epilepsy, GABA uptake, GAT1, Homology modelling, Q299L

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1007/s11064-020-03017-yTest
https://curis.ku.dk/portal/da/publications/pharmacological-characterization-of-a-betainegaba-transporter-1-bgt1-inhibitor-displaying-an-unusual-biphasic-inhibition-profile-and-antiseizure-effectsTest(f58627b3-6c59-4d36-ad00-48d86bf6a034).html
https://curis.ku.dk/ws/files/245321234/Lie2020_Article_PharmacologicalCharacterizatio.pdfTest

المؤلفون: Bechthold, Elena, Grey, Lucie, Diamant, Emil, Schmidt, Judith, Steigerwald, Ruben, Zhao, Fabao, Hansen, Kasper B., Bunch, Lennart, Clausen, Rasmus P., Wünsch, Bernhard

المصدر: Bechthold , E , Grey , L , Diamant , E , Schmidt , J , Steigerwald , R , Zhao , F , Hansen , K B , Bunch , L , Clausen , R P & Wünsch , B 2023 , ' In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs ' , Biological Chemistry , vol. 404 , no. 4 , pp. 255-265 . https://doi.org/10.1515/hsz-2022-0229Test

مصطلحات موضوعية: 3-acylamino-2-aminopropionic acid derivatives, GluN2C subtype-specific NMDA agonists, hydrolytic stability, in vitro ADME, physicochemical parameters, UA3-10

الإتاحة: https://doi.org/10.1515/hsz-2022-0229Test
https://curis.ku.dk/portal/da/publications/in-vitro-adme-characterization-of-a-very-potent-3acylamino2aminopropionic-acidderived-glun2cnmda-receptor-agonist-and-its-ester-prodrugsTest(0798ffab-a247-430a-8b88-9618d9926341).html

المؤلفون: Lie, Maria Ek, Gowing, Emma K, Clausen, Rasmus P, Wellendorph, Petrine, Clarkson, Andrew N

المصدر: Lie , M E , Gowing , E K , Clausen , R P , Wellendorph , P & Clarkson , A N 2018 , ' Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia ' , Journal of Cerebral Blood Flow and Metabolism , vol. 38 , no. 1 , pp. 166-173 . https://doi.org/10.1177/0271678X17743669Test

مصطلحات موضوعية: Journal Article

الإتاحة: https://doi.org/10.1177/0271678X17743669Test
https://curis.ku.dk/portal/da/publications/inhibition-of-gaba-transporters-fails-to-afford-significant-protection-following-focal-cerebral-ischemiaTest(46d280cb-3395-4277-8222-397148525119).html

المؤلفون: Fjelbye, Kasper, Marigo, Mauro, Clausen, Rasmus P., Jørgensen, Erling B., Christoffersen, Claus T., Juhl, Karsten

المصدر: Fjelbye , K , Marigo , M , Clausen , R P , Jørgensen , E B , Christoffersen , C T & Juhl , K 2018 , ' Elucidation of fluorine's impact on p K a and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors ' , MedChemComm , vol. 9 , no. 5 , pp. 893-896 . https://doi.org/10.1039/c8md00114fTest

الإتاحة: https://doi.org/10.1039/c8md00114fTest
https://curis.ku.dk/portal/da/publications/elucidation-of-fluorines-impact-on-pka-and-in-vitro-pgpmediated-efflux-for-a-series-of-pde9-inhibitorsTest(00ed8ff8-9911-4a13-9c42-473010250fa8).html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071825/pdf/MD-009-C8MD00114F.pdfTest

المؤلفون: Lie, Maria EK, Gowing, Emma K, Clausen, Rasmus P, Wellendorph, Petrine, Clarkson, Andrew N

المصدر: Journal of Cerebral Blood Flow & Metabolism ; volume 38, issue 1, page 166-173 ; ISSN 0271-678X 1559-7016

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology

الإتاحة: https://doi.org/10.1177/0271678x17743669Test

المؤلفون: Bechthold, Elena, Grey, Lucie, Diamant, Emil, Schmidt, Judith, Steigerwald, Ruben, Zhao, Fabao, Hansen, Kasper B., Bunch, Lennart, Clausen, Rasmus P., Wünsch, Bernhard

المساهمون: National Institutes of Health, Deutsche Forschungsgemeinschaft

المصدر: Biological Chemistry ; volume 404, issue 4, page 255-265 ; ISSN 1431-6730 1437-4315

الإتاحة: https://doi.org/10.1515/hsz-2022-0229Test