Salmonella Enteritidis ST183: emerging and endemic biotypes affecting western European hedgehogs (Erinaceus europaeus) and people in Great Britain
| العنوان: | Salmonella Enteritidis ST183: emerging and endemic biotypes affecting western European hedgehogs (Erinaceus europaeus) and people in Great Britain |
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| المؤلفون: | Romain Pizzi, Shinto K. John, Philip M. Ashton, Lydia H. V. Franklinos, Elizabeth de Pinna, Clare Wend-Hansen, Satheesh Nair, Julia Rodriguez-Ramos Fernandez, Becki Lawson, Andrew A. Cunningham, Shaheed K. Macgregor, Alejandro Núñez |
| المصدر: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) |
| بيانات النشر: | Nature Publishing Group UK, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Genotype, Salmonella enteritidis, 030106 microbiology, Population, Zoology, lcsh:Medicine, Salmonella infection, Disease Vectors, Article, 03 medical and health sciences, Feces, Zoonoses, medicine, Animals, Humans, education, Clade, lcsh:Science, Hedgehog, Histiocytic Necrotizing Lymphadenitis, Phylogeny, education.field_of_study, Multidisciplinary, Erinaceus, biology, Zoonotic Infection, lcsh:R, Infant, Newborn, Infant, biology.organism_classification, medicine.disease, United Kingdom, Bacterial Typing Techniques, 030104 developmental biology, Hedgehogs, Child, Preschool, Salmonella Infections, Multilocus sequence typing, lcsh:Q, Female, Salmonella Phages, Multilocus Sequence Typing |
| الوصف: | The impacts of hedgehog (Erinaceus europaeus) Salmonella infection on public health and on animal welfare and conservation are unknown. We isolated Salmonella Enteritidis multi-locus sequence-type (ST)183 from 46/170 (27%) hedgehog carcasses (27 S. Enteritidis phage type (PT)11, 18 of a novel PT66 biotype and one with co-infection of these PTs) and from 6/208 (3%) hedgehog faecal samples (4 PT11, 2 PT66) from across Great Britain, 2012–2015. Whole genome phylogenetic analysis of the hedgehog isolates and ST183 from people in England and Wales found that PT11 and PT66 form two divergent clades. Hedgehog and human isolates were interspersed throughout the phylogeny indicating that infections in both species originate from a common population. PT11 was recovered from hedgehogs across England and Scotland, consistent with endemic infection. PT66 was isolated from Scotland only, possibly indicating a recent emergence event. People infected with ST183 were four times more likely to be aged 0–4 years than people infected by the more common ST11 S. Enteritidis. Evidence for human ST183 infection being non-foodborne included stronger correlation between geographic and genetic distance, and significantly increased likelihood of infection in rural areas, than for ST11. These results are consistent with hedgehogs acting as a source of zoonotic infection. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864ba3ae25be2b3dcd83f6d2eabd6dabTest http://europepmc.org/articles/PMC5799193Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....864ba3ae25be2b3dcd83f6d2eabd6dab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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