المؤلفون: Anne Edwards, Isaac Njaci, Abhimanyu Sarkar, Zhouqian Jiang, Gemy George Kaithakottil, Christopher Moore, Jitender Cheema, Clare E. M. Stevenson, Martin Rejzek, Petr Novák, Marielle Vigouroux, Martin Vickers, Roland H. M. Wouters, Pirita Paajanen, Burkhard Steuernagel, Jonathan D. Moore, Janet Higgins, David Swarbreck, Stefan Martens, Colin Y. Kim, Jing-Ke Weng, Sagadevan Mundree, Benjamin Kilian, Shiv Kumar, Matt Loose, Levi Yant, Jiří Macas, Trevor L. Wang, Cathie Martin, Peter M. F. Emmrich

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/66071d22de3b49e497d4e23d84d5e4d0Test

المؤلفون: Anne Edwards, Isaac Njaci, Abhimanyu Sarkar, Zhouqian Jiang, Gemy George Kaithakottil, Christopher Moore, Jitender Cheema, Clare E. M. Stevenson, Martin Rejzek, Petr Novák, Marielle Vigouroux, Martin Vickers, Roland H. M. Wouters, Pirita Paajanen, Burkhard Steuernagel, Jonathan D. Moore, Janet Higgins, David Swarbreck, Stefan Martens, Colin Y. Kim, Jing-Ke Weng, Sagadevan Mundree, Benjamin Kilian, Shiv Kumar, Matt Loose, Levi Yant, Jiří Macas, Trevor L. Wang, Cathie Martin, Peter M. F. Emmrich

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/6e0024d644014264a638d235ef617beeTest

المؤلفون: Alice L. B. Pyne, Agnes Noy, Kavit H. S. Main, Victor Velasco-Berrelleza, Michael M. Piperakis, Lesley A. Mitchenall, Fiorella M. Cugliandolo, Joseph G. Beton, Clare E. M. Stevenson, Bart W. Hoogenboom, Andrew D. Bates, Anthony Maxwell, Sarah A. Harris

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/728c1ae4dbb4491c9742de5d69efdcabTest

المؤلفون: Anja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/3c2f423c4f2146d28e6a3bf66952a1ceTest

المؤلفون: Anna Stavrinides, Evangelos C. Tatsis, Lorenzo Caputi, Emilien Foureau, Clare E. M. Stevenson, David M. Lawson, Vincent Courdavault, Sarah E. O'Connor

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/7fa19d5198334538bd3e87a811316141Test

المؤلفون: Andrej Emanuel Cotman (5203904), Martina Durcik (8648943), Davide Benedetto Tiz (10499510), Federica Fulgheri (10499513), Daniela Secci (1456555), Maša Sterle (10499516), Štefan Možina (7827599), Žiga Skok (9526072), Nace Zidar (1550383), Anamarija Zega (145577), Janez Ilaš (1550377), Lucija Peterlin Mašič (14420614), Tihomir Tomašič (1550395), Diarmaid Hughes (55014), Douglas L. Huseby (5082230), Sha Cao (194620), Linnéa Garoff (14420617), Talía Berruga Fernández (14420620), Paraskevi Giachou (14420623), Lisa Crone (14420626), Ivailo Simoff (13298093), Richard Svensson (1294284), Bryndis Birnir (113570), Sergiy V. Korol (13999896), Zhe Jin (43692), Francisca Vicente (484392), Maria C. Ramos (9616038), Mercedes de la Cruz (484390), Björn Glinghammar (14420629), Lena Lenhammar (4004096), Sara R. Henderson (14420632), Julia E. A. Mundy (7140383), Anthony Maxwell (9506), Clare E. M. Stevenson (9526084), David M. Lawson (357139), Guido V. Janssen (14420635), Geert Jan Sterk (3832357), Danijel Kikelj (1550389)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Cancer, Infectious Diseases, Space Science, Chemical Sciences not elsewhere classified, plasma free fraction, ion channel liabilities, fold decreased inhibition, escherichia coli gyrb24, dna gyrase inhibitor, human topoisomerase iiα, fold improved inhibition, aeruginosa gyrb24 revealed, 27 , 1 , topoisomerase iv, >)-< b, retained anti, resistant bacteria, pseudomonas aeruginosa, promising activity, priority list, potent activity, optimization steps, negative activity, mitochondrial toxicity

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_and_Hit-to-Lead_Optimization_of_Benzothiazole_Scaffold-Based_DNA_Gyrase_Inhibitors_with_Potent_Activity_against_Acinetobacter_baumannii_and_Pseudomonas_aeruginosa/21893086Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.2c01597.s001Test

المؤلفون: Catriona M. A. Thompson, Richard H. Little, Clare E. M. Stevenson, David M. Lawson, Jacob G. Malone

مصطلحات موضوعية: Structural Biology, Molecular Biology, Biochemistry

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ad3b52a286058a8776ce8be8603fecTest
https://ueaeprints.uea.ac.uk/id/eprint/89301Test/

المؤلفون: Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz, Federica Fulgheri, Daniela Secci, Maša Sterle, Štefan Možina, Žiga Skok, Nace Zidar, Anamarija Zega, Janez Ilaš, Lucija Peterlin Mašič, Tihomir Tomašič, Diarmaid Hughes, Douglas L. Huseby, Sha Cao, Linnéa Garoff, Talía Berruga Fernández, Paraskevi Giachou, Lisa Crone, Ivailo Simoff, Richard Svensson, Bryndis Birnir, Sergiy V. Korol, Zhe Jin, Francisca Vicente, Maria C. Ramos, Mercedes de la Cruz, Björn Glinghammar, Lena Lenhammar, Sara R. Henderson, Julia E. A. Mundy, Anthony Maxwell, Clare E. M. Stevenson, David M. Lawson, Guido V. Janssen, Geert Jan Sterk, Danijel Kikelj

المساهمون: Medicinal chemistry, AIMMS

المصدر: Journal of medicinal chemistry, vol. 66, no. 2, 2023.
Journal of medicinal chemistry, str. 1380-1425 : Ilustr., Vol. 66, no. 2, 2023
COBISS-ID: 512806681
Journal of medicinal chemistry, 66(2), 1380-1425. American Chemical Society
Cotman, A E, Durcik, M, Benedetto Tiz, D, Fulgheri, F, Secci, D, Sterle, M, Možina, Š, Skok, Ž, Zidar, N, Zega, A, Ilaš, J, Peterlin Mašič, L, Tomašič, T, Hughes, D, Huseby, D L, Cao, S, Garoff, L, Berruga Fernández, T, Giachou, P, Crone, L, Simoff, I, Svensson, R, Birnir, B, Korol, S V, Jin, Z, Vicente, F, Ramos, M C, De La Cruz, M, Glinghammar, B, Lenhammar, L, Henderson, S R, Mundy, J E A, Maxwell, A, Stevenson, C E M, Lawson, D M, Janssen, G V, Sterk, G J & Kikelj, D 2023, ' Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa ', Journal of medicinal chemistry, vol. 66, no. 2, pp. 1380-1425 . https://doi.org/10.1021/acs.jmedchem.2c01597Test

مصطلحات موضوعية: antibacterial activity, bacteria, genetics, inhibitors, solubility, zaviralci, topnost, bakterijska rezistenca, solubility, Bakterijska rezistenca, Topnost, Läkemedelskemi, udc:615, bakterije, Bakterije, antibacterial activity, genetika, Drug Discovery, inhibitors, Molecular Medicine, antibakterijsko delovanje, zaviralci, genetics, antibakterijsko delovanje, Genetika, Medicinal Chemistry, bacteria, udc:615.015.8

وصف الملف: application/pdf; text/url

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20d28e0e61c3b400f08f6903958d25fTest
https://repozitorij.uni-lj.si/Dokument.php?id=166579&dnTest=

المؤلفون: Martina Durcik, Andrej Emanuel Cotman, Žan Toplak, Štefan Možina, Žiga Skok, Petra Eva Szili, Márton Czikkely, Elvin Maharramov, Thu Hien Vu, Maria Vittoria Piras, Nace Zidar, Janez Ilaš, Anamarija Zega, Jurij Trontelj, Luis A. Pardo, Diarmaid Hughes, Douglas Huseby, Tália Berruga-Fernández, Sha Cao, Ivailo Simoff, Richard Svensson, Sergiy V. Korol, Zhe Jin, Francisca Vicente, Maria C. Ramos, Julia E. A. Mundy, Anthony Maxwell, Clare E. M. Stevenson, David M. Lawson, Björn Glinghammar, Eva Sjöström, Martin Bohlin, Joanna Oreskär, Sofie Alvér, Guido V. Janssen, Geert Jan Sterk, Danijel Kikelj, Csaba Pal, Tihomir Tomašič, Lucija Peterlin Mašič

المساهمون: Medicinal chemistry, AIMMS

المصدر: Durcik, M, Cotman, A E, Toplak, Ž, Možina, Š, Skok, Ž, Szili, P E, Czikkely, M, Maharramov, E, Vu, T H, Piras, M V, Zidar, N, Ilaš, J, Zega, A, Trontelj, J, Pardo, L A, Hughes, D, Huseby, D, Berruga-Fernández, T, Cao, S, Simoff, I, Svensson, R, Korol, S V, Jin, Z, Vicente, F, Ramos, M C, Mundy, J E A, Maxwell, A, Stevenson, C E M, Lawson, D M, Glinghammar, B, Sjöström, E, Bohlin, M, Oreskär, J, Alvér, S, Janssen, G V, Sterk, G J, Kikelj, D, Pal, C, Tomašič, T & Peterlin Mašič, L 2023, ' New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus ', Journal of medicinal chemistry, vol. 66, no. 6, pp. 3968-3994 . https://doi.org/10.1021/acs.jmedchem.2c01905Test
Journal of medicinal chemistry, 66(6), 3968-3994. American Chemical Society
Journal of Medicinal Chemistry
Journal of medicinal chemistry, str. 3968-3994 : Ilustr., Vol. 66, iss. 6, 2023
COBISS-ID: 512806681
Journal of medicinal chemistry, vol. 66, no. 6, pp. 3968-3994, 2023.

مصطلحات موضوعية: Infectious Medicine, topoizomeraza IV, bakterijska rezistenca, nanomolarni inhibitorji benzotiazola, Farmacevtska kemija, Infektionsmedicin, peptides and proteins, antibakterijsko delovanje, zaviralci, nanomolarni inhibitorji benzotiazola, topoizomeraza IV, Microbiology in the medical area, Bakterije, antibacterial activity, SDG 3 - Good Health and Well-being, inhibitors, Drug Discovery, Mikrobiologi inom det medicinska området, genetics, antibakterijsko delovanje, bacteria, zaviralci, Bakterijska rezistenca, Läkemedelskemi, antibacterial activity, bacteria, inhibitors, udc:615, inhibition, bakterije, farmacevtska kemija, Molecular Medicine, Medicinal Chemistry, udc:615.015.8

وصف الملف: application/pdf; text/url

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c3d01f7594899ad1504d0f95893f77Test
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-501871Test

المؤلفون: Mauricio P. Contreras, Hsuan Pai, Muniyandi Selvaraj, AmirAli Toghani, David M. Lawson, Yasin Tumtas, Cian Duggan, Enoch Lok Him Yuen, Clare E. M. Stevenson, Adeline Harant, Abbas Maqbool, Chih-Hang Wu, Tolga O. Bozkurt, Sophien Kamoun, Lida Derevnina

مصطلحات موضوعية: Multidisciplinary

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2765d5778e3ddd51f2cdf1092c5d53b0Test
https://doi.org/10.1101/2022.12.11.519957Test