التفاصيل البيبلوغرافية
| العنوان: |
Presentation_4_Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults.pdf |
| المؤلفون: |
Jennifer Zitser (10127057), Kaitlin B. Casaletto (7009337), Adam M. Staffaroni (5989220), Claire Sexton (4115794), Sophia Weiner-Light (10127060), Amy Wolf (408984), Jesse A. Brown (10127063), Bruce L. Miller (8450160), Joel H. Kramer (7397261) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Neuroscience, Pathology, Health Care, Psychiatry (incl. Psychotherapy), Clinical Sciences not elsewhere classified, Central Nervous System, Aged Care Nursing, Aged Health Care, Protein Trafficking, aging, parkinsonism, UPDRS, cognition, fMRI, motor signs |
| الوصف: |
Objectives: To characterize the clinical correlates of subclinical Parkinsonian signs, including longitudinal cognitive and neural (via functional connectivity) outcomes, among functionally normal older adults. Methods: Participants included 737 functionally intact community-dwelling older adults who performed prospective comprehensive evaluations at ~15-months intervals for an average of 4.8 years (standard deviation 3.2 years). As part of these evaluations, participants completed the Unified Parkinson's Disease Rating Scale (UPDRS) longitudinally and measures of processing speed, executive functioning and verbal episodic memory. T1-weighted structural scans and task-free functional MRI scans were acquired on 330 participants. We conducted linear mixed-effects models to determine the relationship between changes in UPDRS with cognitive and neural changes, using age, sex, and education as covariates. Results: Cognitive outcomes were processing speed, executive functioning, and episodic memory. Greater within-person increases in UPDRS were associated with more cognitive slowing over time. Although higher average UPDRS scores were significantly associated with overall poorer executive functions, there was no association between UPDRS and executive functioning longitudinally. UPDRS scores did not significantly relate to longitudinal memory performances. Regarding neural correlates, greater increases in UPDRS scores were associated with reduced intra-subcortical network connectivity over time. There were no relationships with intra-frontoparietal or inter-subcortical-frontoparietal connectivity. Conclusions: Our findings add to the aging literature by indicating that mild motor changes are negatively associated with cognition and network connectivity in functionally intact adults. |
| نوع الوثيقة: |
conference object |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/presentation/Presentation_4_Mild_Motor_Signs_Matter_in_Typical_Brain_Aging_The_Value_of_the_UPDRS_Score_Within_a_Functionally_Intact_Cohort_of_Older_Adults_pdf/13888133Test |
| DOI: |
10.3389/fnagi.2021.594637.s001 |
| الإتاحة: |
https://doi.org/10.3389/fnagi.2021.594637.s001Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.378911D6 |
| قاعدة البيانات: |
BASE |
