المؤلفون: Angelo Scuteri, Chris Wallace, Rachel Hackett, Sonja I. Berndt, Richard B. Hayes, Peter Vollenweider, Susan M. Ring, Lauren Gianniny, Alistair S. Hall, Christopher J. Gillson, Karani Santhanakrishnan Vimaleswaran, Karol Estrada, Thomas Meitinger, Kay-Tee Khaw, Nicholas J. Timpson, Willem H. Ouwehand, Cristen J. Willer, Andy R Ness, Peter S. Chines, Wendy L. McArdle, I. Sadaf Farooqi, Eleftheria Zeggini, Jouko Saramies, Amanda J. Bennett, Matthew A. Sims, Richard M. Watanabe, David M. Evans, Patricia B. Munroe, Toshiko Tanaka, Francis S. Collins, Peter Kraft, Morris Brown, Inês Barroso, Sheila Bingham, John M. C. Connell, Jian'an Luan, Pekka Jousilahti, Amanda F. Elliott, Lachlan J. M. Coin, Parimal Deodhar, Kijoung Song, Ruth J. F. Loos, Eleanor Wheeler, George Davey Smith, Kate Northstone, Joshua C. Randall, Claudia Lamina, André G. Uitterlinden, Dawn M. Waterworth, Tim D. Spector, Robert Luben, Veikko Salomaa, Vincent Mooser, Candace Guiducci, Andrew T. Hattersley, Guillaume Lettre, Guangju Zhai, Gonçalo R. Abecasis, Jaana Laitinen, Cyrus Cooper, David J. Hunter, Noël P. Burtt, Timo T. Valle, Carolin Purmann, Narisu Narisu, Lori L. Bonnycastle, Steven A. McCarroll, Christian Gieger, Albert Hofman, Laura J. Scott, Iris M. Heid, Lu Qi, Kevin B. Jacobs, Toby Johnson, Cornelia M. van Duijn, David Altshuler, David Hadley, Marjo-Riitta Järvelin, Johannes Hebebrand, Stephen J. Chanock, Stephen O'Rahilly, Jaakko Tuomilehto, Cecilia M. Lindgren, Y. C. Loraine Tung, Panagiotis Deloukas, Manjinder S. Sandhu, H-Erich Wichmann, Antonella Mulas, Matthew G. Rees, Jack M. Guralnik, Elaine M. Dennison, Timothy M. Frayling, David P. Strachan, Jonathan Stephens, Inga Prokopenko, Mikko Kuokkanen, Shengxu Li, Leif Groop, Jing Hua Zhao, Paul Elliott, David Schlessinger, Ken K. Ong, Peter Almgren, Massimo Mangino, Manuela Uda, Zorica Jovanovic, Karen L. Mohlke, Leena Peltonen, Michael N. Weedon, Elizabeth K. Speliotes, Markku Laakso, Bo Isomaa, Serena Sanna, Mark J. Caulfield, Gérard Waeber, Martin Ridderstråle, Luigi Ferrucci, Anne U. Jackson, Suzanne Stevens, Aimo Ruokonen, Jacqueline C. M. Witteman, Nicole Soranzo, Kaisa Silander, Mark I. McCarthy, Joel N. Hirschhorn, Nilesh J. Samani, Frank B. Hu, Michael R. Erdos, Paul Scheet, Leonie C. Jacobs, Rosa Maria Roccasecca, Heather M. Stringham, Helen N. Lyon, Konstantinos A. Papadakis, Aki S. Havulinna, Michael Boehnke, Richard N. Bergman, Nicholas J. Wareham, M. Carola Zillikens, Nicholas A. Watkins, Tiinamaija Tuomi, Fernando Rivadeneira, Noha Lim, Edward G. Lakatta, Johanna Kuusisto

المصدر: Nature Genetics, vol. 41, no. 1, pp. 25-34
Nature Genetics
Nature genetics
Nature Genetics; Vol 41

مصطلحات موضوعية: Central Nervous System, medicine.medical_specialty, Quantitative Trait Loci, Medizin, Gene Dosage, 030209 endocrinology & metabolism, Genome-wide association study, Locus (genetics), Biology, FTO gene, Polymorphism, Single Nucleotide, Article, Body Mass Index, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Quantitative Trait, Heritable, SH2B1, Meta-Analysis as Topic, Internal medicine, Genetics, medicine, Humans, Genetic Predisposition to Disease, Obesity, Alleles, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Neuronal growth regulator 1, Anthropometry, Genetics of obesity, Body Weight, 3. Good health, Endocrinology, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Genome-Wide Association Study, Colaus Study, Body mass index

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https://doi.org/10.1038/ng.287Test

المؤلفون: Claudia Lamina, Dawn M. Waterworth, Ramachandran S. Vasan, Alan R. Sinaiko, Jorma Viikari, Alena Stančáková, Nita G. Forouhi, Leo-Pekka Lyytikäinen, Chloe Y Y Cheung, Torben Hansen, Bernhard Paulweber, Ying Wu, Christie M. Ballantyne, Jaakko Tuomilehto, Karen S.L. Lam, Jussi Paananen, James B. Meigs, Jing Hua Zhao, Francis S. Collins, Hans U. Häring, Marie-France Hivert, Joshua W. Knowles, Zari Dastani, Andrew T. Hattersley, Ele Ferrannini, Ching-Ti Liu, Sarah Buxbaum, Mika Kähönen, Peter Henneman, Aurelian Bidulescu, Michael Boehnke, Ruth J. F. Loos, Fatiha el Bouazzaoui, Ulf Smith, Tim D. Spector, Josée Dupuis, Weijia Xie, Thomas Quertermous, Robert K. Semple, Lyudmyla Kedenko, John J. Nolan, Andrew D. Morris, Anne U. Jackson, Cornelia M. van Duijn, Ko Willems van Dijk, Markku Laakso, Robert A. Scott, Na Zhu, Oluf Pedersen, Terho Lehtimäki, Claudia Langenberg, Ke Hao, Christopher J. Gillson, Olli T. Raitakari, Mark I. McCarthy, Florian Kronenberg, Jaeyoung Hong, James S. Pankow, Debbie A Lawlor, Nicholas J. Wareham, Karen L. Mohlke, Timothy M. Frayling, Tanya M. Teslovich, Sandra H. Dunn, Alessandro Doria, Cecilia M. Lindgren, Richard N. Bergman, Johanna Kuusisto, Hanieh Yaghootkar, Liling Warren, Stefan Gustafsson, Erik Ingelsson, Colin N. A. Palmer, Mark Walker, Themistocles L. Assimes, J. Brent Richards

المساهمون: Epidemiology, Medical Microbiology & Infectious Diseases

المصدر: Diabetes, 62(10), 3589-3598
Yaghootkar, H, Lamina, C, Scott, R A, Dastani, Z, Hivert, M F, Warren, L L, Stancakova, A, Buxbaum, S G, Lyytikaeinen, L P, Henneman, P, Wu, Y, Cheung, C Y Y, Pankow, J S, Jackson, A U, Gustafsson, S, Zhao, J H, Ballantyne, C M, Xie, W J, Bergman, R N, Boehnke, M, el Bouazzaoui, F, Collins, F S, Dunn, S H, Dupuis, J, Forouhi, N G, Gillson, C, Hattersley, A T, Hong, J Y, Kaehoenen, M, Kuusisto, J, Kedenko, L, Kronenberg, F, Doria, A, Assimes, T L, Ferrannini, E, Hansen, T, Hao, K, Haering, H, Knowles, J W, Lindgren, C M, Nolan, J J, Paananen, J, Pedersen, O, Quertermous, T, Smith, U, Lehtimaeki, T, Liu, C T, Loos, R J F, McCarthy, M I, Morris, A D, Vasan, R S, Spector, T D, Teslovich, T M, Tuomilehto, J, van Dijk, K W, Viikari, J S, Zhu, N, Langenberg, C, Ingelsson, E, Semple, R K, Sinaiko, A R, Palmer, C N A, Walker, M, Lam, K S L, Paulweber, B, Mohlke, K L, van Duijn, C, Raitakari, O T, Bidulescu, A, Wareham, N J, Laakso, M, Waterworth, D M, Lawlor, D A, Meigs, J B, Richards, J B, Frayling, T M, Consortium, G & Consortium, R 2013, ' Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes ', Diabetes, vol. 62, pp. 3589-3598 . https://doi.org/10.2337/db13-0128Test
Diabetes
Yaghootkar, H, Lamina, C, Scott, R A, Dastani, Z, Hivert, M F, Warren, L L, Stancáková, A, Buxbaum, S G, Lyytikäinen, L P, Henneman, P, Wu, Y, Cheung, C Y Y, Pankow, J S, Jackson, A U, Gustafsson, S, Zhao, J H, Ballantyne, C M, Xie, W, Bergman, R N, Boehnke, M, El Bouazzaoui, F, Collins, F S, Dunn, S H, Dupuis, J, Forouhi, N G, Gillson, C, Hattersley, A T, Hong, J, Kähönen, M, Kuusisto, J, Kedenko, L, Kronenberg, F, Doria, A, Assimes, T L, Ferrannini, E, Hansen, T, Hao, K, Häring, H, Knowles, J W, Lindgren, C M, Nolan, J J, Paananen, J, Pedersen, O, Quertermous, T, Smith, U, Lehtimäki, T, Liu, C T, Loos, R J F, McCarthy, M I, Morris, A D, Vasan, R S, Spector, T D, Teslovich, T M, Tuomilehto, J, Van Dijk, K W, Viikari, J S, Zhu, N, Langenberg, C, Ingelsson, E, Semple, R K, Sinaiko, A R, Palmer, C N A, Walker, M, Lam, K S L, Paulweber, B, Mohlke, K L, Van Duijn, C, Raitakari, O T, Bidulescu, A, Wareham, N J, Laakso, M, Waterworth, D M, Lawlor, D A, Meig, J B, Richards, J B & Frayling, T M 2013, ' Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes ', Diabetes, vol. 62, no. 10, pp. 3589-3598 . https://doi.org/10.2337/db13-0128Test
Diabetes, 62(10), 3589-3598. American Diabetes Association Inc.

مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, ADIPOQ Gene, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, MOLECULAR-WEIGHT ADIPONECTIN GREATER-THAN-G PLASMA ADIPONECTIN ADIPOSE-TISSUE ASSOCIATION ANALYSES METABOLIC PROFILE GENETIC-VARIANTS SUPPRESSION TEST GLYCEMIC TRAITS OBESE WOMEN, 0302 clinical medicine, Insulin resistance, SDG 3 - Good Health and Well-being, Diabetes mellitus, Internal medicine, Mendelian randomization, Odds Ratio, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, Original Research, 030304 developmental biology, 0303 health sciences, Adiponectin, Genetic Variation, Genetics/Genomes/Proteomics/Metabolomics, Mendelian Randomization Analysis, Odds ratio, medicine.disease, 3. Good health, Endocrinology, Diabetes Mellitus, Type 2, Regression Analysis, Female, Insulin Resistance

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https://ora.ox.ac.uk/objects/uuid:fd376590-520a-44d4-a377-1d5ba7bc4b0cTest

المؤلفون: Nicola D. Kerrison, Carlos González, Mark Walker, Adam S. Butterworth, Martina Müller-Nurasyid, Mark I. McCarthy, Jarmo Virtamo, Nilesh J. Samani, Daniel F. Freitag, Jennifer Wessel, Inês Barroso, Jette Bork-Jensen, Marit E. Jørgensen, Torben Hansen, Nita G. Forouhi, Jennifer A. Smith, Peter Vollenweider, Douglas F. Easton, Heiner Boeing, Helena M. Earl, Laufey T. Amundadottir, Annette Peters, Ingrid B. Borecki, L. Adrienne Cupples, Li Li, Josée Dupuis, Sara Benlloch Garcia, J. Wouter Jukema, Shuai Wang, Veikko Salomaa, Jukka Kontto, Timothy J. Key, Yuning Chen, Sune F. Nielsen, Robin Young, Jing Hua Zhao, Andrew P. Morris, Larraitz Arriola, Claudia Langenberg, Joshua C. Bis, Nisa M. Maruthur, Ele Ferrannini, Joanna M. M. Howson, Marcel den Hoed, Jeanette Erdmann, Rosalind A. Eeles, Daphne L. van der A, Panos Deloukas, Eric Boerwinkle, Sara M. Willems, Elio Riboli, Markku Laakso, Gina M. Peloso, Muriel J. Caslake, Nadia Slimani, Zsofia Kote-Jarai, Paul W. Franks, EPIC-InterAct, Dominique Arveiler, Sarah Bowden, Janet A. Dunn, Jan-Håkan Jansson, Carlos Cruchaga, Audrey Y. Chu, James S. Pankow, Rudolf Kaaks, Jerome I. Rotter, Jaspal S. Kooner, Ailith Pirie, Johanna Kuusisto, Hanieh Yaghootkar, Niels Grarup, Danish Saleheen, Thomas Foltynie, Jean Abraham, Stefan Blankenberg, Mark O. Goodarzi, Markus Perola, Olov Rolandsson, Chris J. Packard, Praveen Surendran, Allan Linneberg, Beverley Balkau, Christopher J. Poole, Frank Kee, Carmen Navarro, Nicholas J. Wareham, Oluf Pedersen, Heribert Schunkert, Domenico Palli, Patricia B. Munroe, Sven J. van der Lee, Chunyu Liu, Rebecca Sims, Georg Ehret, Michael Boehnke, Stephen J. Sharp, Peter M. Nilsson, Salvatore Panico, Børge G. Nordestgaard, Aldi T. Kraja, Sara Grioni, Sekar Kathiresan, Dawn M. Waterworth, Francesco Gianfagna, Jacek Czajkowski, Naveed Sattar, Margaret G. Ehm, Christopher J. Gillson, Karen L. Mohlke, Stella Trompet, John Danesh, Carlotta Sacerdote, Gaëlle Marenne, Jian'an Luan, Timothy M. Frayling, J. Ramón Quirós, Iciar Aviles-Olmos, Robert A. Scott, Yvonne T. van der Schouw, Jennifer L. Aponte, María José Sánchez, Deborah J. Thompson, Klaudia Walter, James B. Meigs, Tibor V. Varga, Kari Kuulasmaa, Torben Jørgensen, Rosario Tumino, Kyriaki Michailidou, Kenneth Muir, Philippe Amouyel, Ian Ford, Aurelio Barricarte, Stephen O'Rahilly, Ali Amin Al Olama, Louise Hiller, Alena Stančáková, Carlos Caldas, Jean Ferrières

المساهمون: Scott, Robert A, Freitag, Daniel F, Li, Li, Chu, Audrey Y, Surendran, Praveen, Young, Robin, Grarup, Niel, Stancáková, Alena, Chen, Yuning, Varga, Tibor V, Yaghootkar, Hanieh, Luan, Jian'An, Zhao, Jing Hua, Willems, Sara M, Wessel, Jennifer, Wang, Shuai, Maruthur, Nisa, Michailidou, Kyriaki, Pirie, Ailith, van der Lee, Sven J, Gillson, Christopher, Al Olama, Ali Amin, Amouyel, Philippe, Arriola, Larraitz, Arveiler, Dominique, Aviles Olmos, Iciar, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inê, Garcia, Sara Benlloch, Bis, Joshua C, Blankenberg, Stefan, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Borecki, Ingrid B, Bork Jensen, Jette, Bowden, Sarah, Caldas, Carlo, Caslake, Muriel, Cupples, L. Adrienne, Cruchaga, Carlo, Czajkowski, Jacek, den Hoed, Marcel, Dunn, Janet A, Earl, Helena M, Ehret, Georg B, Ferrannini, Ele, Ferrieres, Jean, Foltynie, Thoma, Ford, Ian, Forouhi, Nita G, Gianfagna, Francesco, Gonzalez, Carlo, Grioni, Sara, Hiller, Louise, Jansson, Jan Håkan, Jørgensen, Marit E, Jukema, J. Wouter, Kaaks, Rudolf, Kee, Frank, Kerrison, Nicola D, Key, Timothy J, Kontto, Jukka, Kote Jarai, Zsofia, Kraja, Aldi T, Kuulasmaa, Kari, Kuusisto, Johanna, Linneberg, Allan, Liu, Chunyu, Marenne, Gaëlle, Mohlke, Karen L, Morris, Andrew P, Muir, Kenneth, Müller Nurasyid, Martina, Munroe, Patricia B, Navarro, Carmen, Nielsen, Sune F, Nilsson, Peter M, Nordestgaard, Børge G, Packard, Chris J, Palli, Domenico, Panico, Salvatore, Peloso, Gina M, Perola, Marku, Peters, Annette, Poole, Christopher J, Quirós, J. Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Salomaa, Veikko, Sánchez, María José, Sattar, Naveed, Sharp, Stephen J, Sims, Rebecca, Slimani, Nadia, Smith, Jennifer A, Thompson, Deborah J, Trompet, Stella, Tumino, Rosario, van der A, Daphne L, van der Schouw, Yvonne T, Virtamo, Jarmo, Walker, Mark, Walter, Klaudia, Abraham, Jean E, Amundadottir, Laufey T, Aponte, Jennifer L, Butterworth, Adam S, Dupuis, Josée, Easton, Douglas F, Eeles, Rosalind A, Erdmann, Jeanette, Franks, Paul W, Frayling, Timothy M, Hansen, Torben, Howson, Joanna M. M, Jørgensen, Torben, Kooner, Jaspal, Laakso, Markku, Langenberg, Claudia, Mccarthy, Mark I, Pankow, James S, Pedersen, Oluf, Riboli, Elio, Rotter, Jerome I, Saleheen, Danish, Samani, Nilesh J, Schunkert, Heribert, Vollenweider, Peter, O'Rahilly, Stephen, Deloukas, Pano, Danesh, John, Goodarzi, Mark O, Kathiresan, Sekar, Meigs, James B, Ehm, Margaret G, Wareham, Nicholas J, Waterworth, Dawn M., Surgery, Epidemiology, Ehret, Georg Benedikt, Surendran, Praveen [0000-0002-4911-6077], Luan, Jian'an [0000-0003-3137-6337], Barroso, Ines [0000-0001-5800-4520], Caldas, Carlos [0000-0003-3547-1489], Earl, Helena [0000-0003-1549-8094], Forouhi, Nita [0000-0002-5041-248X], Sharp, Stephen [0000-0003-2375-1440], Thompson, Deborah [0000-0003-1465-5799], Abraham, Jean [0000-0003-0688-4807], Butterworth, Adam [0000-0002-6915-9015], Easton, Douglas [0000-0003-2444-3247], Howson, Joanna [0000-0001-7618-0050], Langenberg, Claudia [0000-0002-5017-7344], O'Rahilly, Stephen [0000-0003-2199-4449], Danesh, John [0000-0003-1158-6791], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository

المصدر: 341ra76
Scott, R A, Freitag, D F, Li, L, Chu, A Y, Surendran, P, Young, R, Grarup, N, Stancáková, A, Chen, Y, Varga, T V, Yaghootkar, H, Luan, J, Zhao, J H, Willems, S M, Wessel, J, Wang, S, Maruthur, N, Michailidou, K, Pirie, A, van der Lee, S J, Gillson, C, Al Olama, A A, Amouyel, P, Arriola, L, Arveiler, D, Aviles-Olmos, I, Balkau, B, Barricarte, A, Barroso, I, Garcia, S B, Bis, J C, Blankenberg, S, Boehnke, M, Boeing, H, Boerwinkle, E, Borecki, I B, Bork-Jensen, J, Bowden, S, Caldas, C, Caslake, M, Cupples, L A, Cruchaga, C, Czajkowski, J, den Hoed, M, Dunn, J A, Earl, H M, Ehret, G B, Ferrannini, E, Ferrieres, J, Jørgensen, T & CVD50 consortium 2016, ' A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease ', Science Translational Medicine, vol. 8, no. 341, 341ra76 . https://doi.org/10.1126/scitranslmed.aad3744Test
Scott, R A, Freitag, D F, Li, L, Chu, A Y, Surendran, P, Young, C R, Grarup, N, Stancakova, A, Chen, Y, Varga, T V, Yaghootkar, H, Luan, J, Zhao, J H, Willems, S M, Wessel, J, Wang, S, Maruthur, N M, Michailidou, K, Pirie, A, Van Der Lee, S J, Gillson, C J, Amin Al Olama, A, Amouyel, P, Arriola, L, Arveiler, D, Aviles-Olmos, I, Balkau, B, Barricarte, A, Barroso, I, Garcia, S B, Bis, J C, Blankenberg, S, Boehnke, M, Boeing, H, Boerwinkle, E, Borecki, I B, Bork-Jensen, J, Bowden, S, Caldas, C, Caslake, M, Cupples, L A, Cruchaga, C, Czajkowski, J, den Hoed, M, Dunn, J A, Earl, H M, Ehret, G B, Ferrannini, E, Ferrieres, J, Foltynie, T, Ford, I, Forouhi, N G, Gianfagna, F, Gonzalez, C A, Grioni, S, Hiller, L, Jansson, J H, Jørgensen, M E, Jukema, J W, Kaaks, R, Kee, F, Kerrison, N D, J. Key, T, Kontto, J, Kote-Jarai, Z, Kraja, A T, Kuulasmaa, K, Kuusisto, J, Linneberg, A, Liu, C, Marenne, G, Mohlke, K L, Morris, A P, Muir, K, Müller-Nurasyid, M, Munroe, P B, Navarro, C, Nielsen, S F, Nilsson, P M, Nordestgaard, B G, Packard, C J, Palli, D, Panico, S, Peloso, G M, Perola, M, Peters, A, Poole, C J, Quiros, J R, Rolandsson, O, Sacerdote, C, Salomaa, V, Sánchez, M-J, Sattar, N, Sharp, S J, Sims, R, Slimani, N, Smith, J A, Thompson, J D, Trompet, S, Tumino, R, van der A, D L, van der Schouw, Y T, Virtamo, J, Walker, M, Walter, K, Abraham, J E, Amundadottir, L T, Butterworth, A S, Aponte, J L, Dupuis, J, Easton, D F, Eeles, R A, Erdmann, J, Franks, P W, Frayling, T M, Hansen, T, Howson, J M M, Jørgensen, T, Kooner, J, Laakso, M, McCarthy, M I, Pankow, J S, Pedersen, O, Riboli, E, Rotter, J I, Saleheen, D, Samani, N J, Schunkert, H, Vollenweider, P, O'Rahilly, S, Deloukas, P, Danesh, J, Goodarzi, M O, Kathiresan, S, Meigs, J B, Ehm, M G, Wareham, N J & Waterworth, D M 2016, ' A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease ', Science Translational Medicine, bind 8, nr. 341 . https://doi.org/10.1126/scitranslmed.aad3744Test
SCIENCE TRANSLATIONAL MEDICINE
Scott, R A, Freitag, D F, Li, L, Chu, A Y, Surendran, P, Young, R, Grarup, N, Stancáková, A, Chen, Y, Varga, T V, Yaghootkar, H, Luan, J, Zhao, J H, Willems, S M, Wessel, J, Wang, S, Maruthur, N, Michailidou, K, Pirie, A, van der Lee, S J, Gillson, C, Al Olama, A A, Amouyel, P, Arriola, L, Arveiler, D, Aviles-Olmos, I, Balkau, B, Barricarte, A, Barroso, I, Garcia, S B, Bis, J C, Blankenberg, S, Boehnke, M, Boeing, H, Boerwinkle, E, Borecki, I B, Bork-Jensen, J, Bowden, S, Caldas, C, Caslake, M, Cupples, L A, Cruchaga, C, Czajkowski, J, den Hoed, M, Dunn, J A, Earl, H M, Ehret, G B, Ferrannini, E & Ferrieres, J & Foltynie, T 2016, ' A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease ', Science Translational Medicine, vol. 8, no. 341, pp. 341ra76 . https://doi.org/10.1126/scitranslmed.aad3744Test
Science Translational Medicine, 8(341)
Science Translational Medicine, 8(341):341ra76. American Association for the Advancement of Science
Science Translational Medicine, Vol. 8, No 341 (2016) P. 341ra76
Science Translational Medicine, 8(341). American Association for the Advancement of Science

مصطلحات موضوعية: Type 2/genetics, 0301 basic medicine, Somatostatin/genetics, Heart disease, Epidemiology, CHARGE consortium, Obesity/genetics, RECEPTOR AGONIST LIXISENATIDE, Coronary Disease, Type 2 diabetes, Research & Experimental Medicine, Bioinformatics, PLACEBO-CONTROLLED TRIAL, Receptor, Cannabinoid, CB2, DOUBLE-BLIND, Dipeptidyl Peptidase 4/genetics, 0302 clinical medicine, ONCE-DAILY LIXISENATIDE, Receptors, Receptor, Serotonin, 5-HT2C, Receptors, Somatostatin, Exome sequencing, GLUCAGON-LIKE PEPTIDE-1, CHD Exome+ Consortium, Neurology Working Group of the Cohorts for Heart, General Medicine, 11 Medical And Health Sciences, RANDOMIZED CONTROLLED-TRIAL, 3. Good health, Coronary Disease/genetics, 5-HT2C/genetics, CVD50 consortium, Drug development, Medicine, Research & Experimental, EPIC-InterAct, Public Health, Life Sciences & Biomedicine, INCRETIN-BASED THERAPIES, Receptor, Serotonin, RM, European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD), Genotype, Dipeptidyl Peptidase 4, CB2/genetics, TYPE-2 DIABETES-MELLITUS, 030209 endocrinology & metabolism, Article, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Sodium-Glucose Transporter 1, BETA-CELL FUNCTION, Diabetes mellitus, Diabetes Mellitus, Journal Article, medicine, Humans, Sodium-Glucose Transporter 1/genetics, Obesity, Cannabinoid, Alleles, Science & Technology, business.industry, Alzheimer’s Disease Genetics Consortium, Glucagon-Like Peptide-1 Receptor/genetics, GERAD_EC Consortium, Cell Biology, 06 Biological Sciences, medicine.disease, R1, Human genetics, CARDIOGRAM Exome Consortium, Clinical trial, Minor allele frequency, BODY-MASS INDEX, 030104 developmental biology, Diabetes Mellitus, Type 2, Aging Research in Genomic Epidemiology (CHARGE), business, RC, Pancreatic Cancer Cohort Consortium

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http://hdl.handle.net/11588/650489Test

المؤلفون: Yali Xue, Cara Woodwark, Ni Huang, Yuan Chen, Allan Daly, Donald F. Conrad, S. Qasim Mehdi, Christopher J. Gillson, Pu Li, Bryndis Yngvadottir, Alexandra C. Nica, Chris Tyler-Smith, Qasim Ayub, Xuelong Zhang, Daniel G. MacArthur

المصدر: Genetics. 183:1065-1077

مصطلحات موضوعية: Genotype, Ubiquitin-Protein Ligases, Population, Receptors, Cell Surface, Single-nucleotide polymorphism, Investigations, Biology, Polymorphism, Single Nucleotide, Gene Frequency, Antigens, CD, Genetic variation, Genetics, Guanine Nucleotide Exchange Factors, Humans, Selection, Genetic, International HapMap Project, Poly-ADP-Ribose Binding Proteins, education, Allele frequency, Genotyping, Selection (genetic algorithm), education.field_of_study, Edar Receptor, Genome, Human, Haplotype, Alcohol Dehydrogenase, DNA Helicases, Intracellular Signaling Peptides and Proteins, Genetic Variation, Sequence Analysis, DNA, DNA Repair Enzymes, Genetics, Population, Haplotypes, Duffy Blood-Group System, Cell Adhesion Molecules

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c34c9315befc0de1f6a9adfbc84726bTest
https://doi.org/10.1534/genetics.109.107722Test

المؤلفون: Margaret G. Ehm, Lea Sarov-Blat, Robert A. Scott, Dennis L. Sprecher, Alex P. Reiner, Bruce M. Psaty, Jennifer L. Aponte, Josée Dupuis, Li Li, Nicholas J. Wareham, Ruth McPherson, Honghuang Lin, Russell P. Tracy, Christopher J. Gillson, Stephanie L. Chissoe, Dawn M. Waterworth, Liling Warren

المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

مصطلحات موضوعية: Oncology, Adult, Male, medicine.medical_specialty, rare variation, Genotype, Population, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, acute coronary syndrome, Mitogen-Activated Protein Kinase 14, Framingham Heart Study, Mitogen-Activated Protein Kinase 11, Risk Factors, Internal medicine, Genetic model, Genetics, Medicine, Humans, Exome, Obesity, education, drug target gene, Original Research, Aged, Dyslipidemias, Peroxidase, 2. Zero hunger, Metabolic Syndrome, education.field_of_study, Losmapimod, business.industry, Genetics of obesity, Sequence Analysis, DNA, Middle Aged, medicine.disease, Prognosis, 3. Good health, myeloperoxidase, Endocrinology, Logistic Models, Genetic epidemiology, Cardiovascular Diseases, Linear Models, Female, Metabolic syndrome, Cardiology and Cardiovascular Medicine, business, exome sequencing

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f29978a1913c8042d18ce37d2e89216Test
http://europepmc.org/articles/PMC4310399Test

المؤلفون: L K Colman, S S White, R Heathcott, K D Ambrose, C Griffiths, C L Bagguley, Christine Lloyd, Jim Davies, James G. R. Gilbert, Richard Durbin, Carol Scott, Rebekah Hall, Graeme Bethel, Adrienne Hunt, C Carder, A Tromans, G Tamlyn-Hall, Jane Rogers, J Garnett, L M Faulkner, J C Chapman, Benjamin Phillimore, M Grant, A Wild, Christopher J. Gillson, S Hammond, A K Babbage, Sophie Palmer, C. D. Skuce, V. Cobley, Margaret A. Leversha, Robert W. Plumb, J. M. Wallis, Lucy Matthews, Sarah E. Smith, Mark Griffiths, Karen Oliver, J Tester, Christopher M. Johnson, M Earthrowl, K L Novik, Graeme T Clark, Kirsten McLay, Michelle Smith, R M Younger, T Nickerson, K F Barlow, A. King, S. M. Clegg, Mark T. Ross, K M Culley, R. E. Collier, K Bates, Nigel P. Carter, Sarah E. Hunt, Matthew Humphries, Kevin L. Howe, R Ainscough, Matthew Jones, J P Almeida, Laurens G. Wilming, R Patel, C M Clee, A M Kimberley, David Niblett, Gareth Maslen, Jane E. Loveland, Pawandeep Dhami, J C Wyatt, Philip Howden, Harminder Sehra, N Corby, Stephan Beck, Andrew J. Mungall, Cordelia Langford, Mohammed J. R. Ghori, O. T. McCann, Sarah Milne, Ian Dunham, C A Edwards, J Y Brown, Matthew Dunn, A J Theaker, Darren Grafham, Alan Tracey, S. Searle, Anne Parker, John Burton, Amanda McMurray, H Whittaker, R I S Ashwell, M Mashreghi-Mohammadi, P Garner, A J Brown, O. Beasley, Michele Clamp, A Thorpe, Daniel Leongamornlert, Alan Coulson, Y. Ramsey, Paul Wray, N Sycamore, Helen Beasley, M. J F Moore, Dave Willey, K M Porter, S Y Clark, A I Peck, Tim Hubbard, D. M. Lloyd, David R. Bentley, A Joy, Joanna Harley, L Spraggon, J Lovell, Anthony P. West, E. Hart, Adam Frankish, M. Kay, Catherine M. Rice, Matthew D. Francis, S A Ranby, Duncan W. Thomas, Elizabeth J. Huckle, T. E. Wilmer, Sean Humphray, L Young, W Burrill, David Beare, B Tubby, S Lawlor, E Sheridan, Susan M. Gribble, J Frankland, A E Ellington, Charles A. Steward, K S Halls, Roger Horton, Melanie M. Wall, James C. Mullikin, D C Burford, S. Holmes, L M Gilby, T D Andrews, Christine P. Bird, Gareth R. Howell, Stephen Keenan, Joanna Collins, S. Squares, Ruby Banerjee, Jennifer L. Ashurst, Sarah Sims, S Bray-Allen, Lisa French, G. J. Coville, Paul Heath, A. V. Pearce, S. Whitehead, Sancha Martin, J Bailey, J Brook, Darren Barker, Rebecca Glithero, Jonathan Wood, E K Overton-Larty, K A Evans, S. Blakey, John Sulston, Gavin K. Laird, Sam Phillips, S J McLaren

المصدر: Nature. 429:369-374

مصطلحات موضوعية: Male, Genetics, Medical, Biology, Article, Euchromatin, Evolution, Molecular, Chromosome 15, Chromosome 16, Genes, Duplicate, Gene Duplication, Heterochromatin, Neoplasms, Chromosome 19, Humans, Chromosome 13, Genetics, Base Composition, Multidisciplinary, Genetic Variation, Neurodegenerative Diseases, Genomics, Sequence Analysis, DNA, Sex Determination Processes, Physical Chromosome Mapping, Chromosome 17 (human), Genes, Chromosome 3, Female, Chromosomes, Human, Pair 9, Chromosome 21, Chromosome 22, Pseudogenes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb4a5947796c48eccf8e948aa91b0c7Test
https://doi.org/10.1038/nature02465Test

المؤلفون: Matthew A. Sims, Joanna Poulton, Claudia Langenberg, Nicholas J. Wareham, Kay-Tee Khaw, Magdalena Plotka, Christopher J. Gillson, Zheng Ye

المصدر: Diabetologia

مصطلحات موضوعية: Mitochondrial DNA, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Biology, Origin of replication, DNA, Mitochondrial, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Internal Medicine, Humans, Genetic Predisposition to Disease, 030304 developmental biology, Genetics, 0303 health sciences, OriB variant, Pyrosequencing, Human physiology, Europid populations, medicine.disease, 3. Good health, Diabetes Mellitus, Type 2, Meta-analysis, Systematic review, Meta-Analysis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17471b9371c3be9c253ef1923b654f9aTest
https://pubmed.ncbi.nlm.nih.gov/23702607Test

المؤلفون: Yali Xue, Chris Tyler-Smith, Qasim Ayub, Alison J. Coffey, Oscar Lao, S. Qasim Mehdi, Cara Woodwark, Mark Vermeulen, Johanna Maria de Gruijter, Christopher J. Gillson, Manfred Kayser

المساهمون: Genetic Identification, Apollo - University of Cambridge Repository

المصدر: Investigative Genetics, 2. BioMed Central Ltd.
Investigative Genetics

مصطلحات موضوعية: OCA2, Genetics, 0303 health sciences, Research, Haplotype, Single-nucleotide polymorphism, Biology, medicine.disease, Oculocutaneous albinism, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, medicine, Human genome, TYRP1, Selective sweep, Molecular Biology, Genotyping, 030217 neurology & neurosurgery, 030304 developmental biology

وصف الملف: application/pdf; text/xml; application/vnd.ms-excel; application/msword

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89fdbe3df754d926b7e9efe9e3ceddabTest
https://pure.eur.nl/en/publications/e0cf3f00-2712-4583-864f-481e8400e44eTest

المؤلفون: Matthew A. Sims, Rebecca Hardy, Andy R Ness, Andrew Wong, Carol Rubin, Jing Hua Zhao, Ulf Ekelund, Ken K. Ong, Michele Marcus, Jean Golding, Cathy E. Elks, Peter Vollenweider, Dawn M. Waterworth, Beate Glaser, Panagiotis Deloukas, Ruth J. F. Loos, Inês Barroso, Sheila Bingham, Diana Kuh, Vincent Mooser, George Davey Smith, Kate Northstone, Nicholas J. Wareham, Jian'an Luan, Susan M. Ring, Christopher J. Gillson, Robert Luben, Gérard Waeber, Michael A. McGeehin, Kay-Tee Khaw, Lars Bo Andersen, Shengxu Li, Kijoung Song, David P. Strachan, Soren Brage

المصدر: Nature Genetics, vol. 41, no. 6, pp. 729-733
Nature genetics

مصطلحات موضوعية: 0303 health sciences, medicine.medical_specialty, Body height, Genetic variants, Physiology, 030209 endocrinology & metabolism, Biology, Colaus Study, Article, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Genetic variation, Genetics, medicine, Menarche, Genetic variability, 030304 developmental biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948b0cd0f20e76e3f9622d8fd5ef240aTest
https://europepmc.org/articles/PMC3000552Test/

المؤلفون: Nigel P. Carter, Ian Dunham, A. L. Atkinson, Jaime Hughes, M. Izmajlowicz, Richard Durbin, Mark T. Ross, Soumi Joseph, Adam Butler, G. L. Harper, Louise McDonald, Rohan Taylor, W. D. Burrill, Graeme Bethel, S. R. Prathalingam, David R. Bentley, Theologia Sarafidou, Vassos Neocleous, John Sulston, F. L. Dearden, C. M. Rice, E. C. Sotheran, Carol A. Edwards, S. M. Clegg, N. Brady, T. E. Wilmer, B. L. Hopkins, G. L. Maslen, Simon G. Gregory, Owen T. McCann, Andrew J. Mungall, M.A. Leversha, Elisabeth Dawson, K. J. Phillips, R Evans, A. A. Thorpe, C M Clee, Cordelia Langford, E. J. Huckle, Helen E. Steingruber, Carol Scott, Y. H. Ramsey, John E. Collins, Gareth R. Howell, Adam Whittaker, M. E. Earthrowl, M. H. Lehvaslaiho, Pamela Whittaker, G. Laird, J. C. Brook, D. J. Scott, K. J. Ashcroft, S. H. Williams, Georgina Warry, Nicholas K. Moschonas, D. M. Pearson, K. S. Halls, C. L. Wright, R. W. Heathcott, C. Carder, Jane L. Holden, D. C. Burford, S. A. Ranby, P. J. Howard, K. Aubin, K. M. Porter, E. Holloway, R. A. Cooper, A. J. Coffey, David Beare, J. J. Catanese, C. A. Jones, J. S. Conquer, J. Ghori, E. J. Tinsley, Lisa French, Charlotte G. Cole, P. D. Dhami, K. M. Culley, Christopher J. Gillson, Sarah E. Hunt, Rhian Gwilliam, Panagiotis Deloukas, V. Cobley, Carol Soderlund, A. Taylor, G. J. Sharp, Luc J. Smink, S. Hammond, Andrew Dunham, L. J. Rogers, D. Mistry, Richard Wooster, P. J. De Jong, Jane Rogers, P. J. Hunt, L D Green, C. J. Shaw-Smith, Jennifer McDowall, C. Burrows, Sean Humphray

المصدر: Nature. 409(6822)

مصطلحات موضوعية: Genetics, Multidisciplinary, X Chromosome, Contig, Gene map, Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 10, Genome, Human, Chromosomes, Human, Pair 20, food and beverages, Chromosome, Computational biology, Biology, Genome, Contig Mapping, Gene mapping, Chromosomes, Human, Pair 1, Humans, Chromosomes, Human, Pair 6, X chromosome, Genomic organization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27694cfff37462eade29db6f628e73dTest
https://pubmed.ncbi.nlm.nih.gov/11237015Test