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المؤلفون: Phil S. Baran, Shobin Shaji, Kyohei Hayashi, Yu Kawamata, Dirk Waldmann, Masato Saito, Jacob T. Edwards, Bryan J Simmons, Christoph W Zapf, Ethan Carlson
المصدر: J Am Chem Soc
مصطلحات موضوعية: Chiral auxiliary, Substrate (chemistry), Context (language use), General Chemistry, Electrosynthesis, Biochemistry, Combinatorial chemistry, Catalysis, Article, chemistry.chemical_compound, Colloid and Surface Chemistry, chemistry, Reagent, Reactivity (chemistry), Organic synthesis, Chemoselectivity, Organic Chemicals
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a7e907fe854ab288ebd237db4cceb1Test
https://doi.org/10.26434/chemrxiv.14394602Test -
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المؤلفون: Jeanne Chang, Ravi G. Kurumbail, Margaret Fleming, Joanne Brodfuehrer, Katherine L. Lee, Frank Lovering, Shashi Mohan, Heather V. Dowty, Fabien Vincent, Jayasankar Jasti, Steve Kortum, Christoph W. Zapf, Jotham Wadsworth Coe, Christophe Allais, Strohbach Joseph Walter, Nikolaos Papaioannou, Ann Aulabaugh, Julia A. Guzova, Paul Morgan, Richard K. Frisbie, WeiDong Ding, David Hepworth
المصدر: European Journal of Medicinal Chemistry. 145:606-621
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Pharmacology, Crystallography, X-Ray, MAP Kinase Kinase Kinase 5, medicine.disease_cause, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Humans, Structure–activity relationship, ASK1, Kinome, Protein Kinase Inhibitors, Cells, Cultured, chemistry.chemical_classification, Reactive oxygen species, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Organic Chemistry, HEK 293 cells, General Medicine, Amides, Recombinant Proteins, HEK293 Cells, 030104 developmental biology, chemistry, Apoptosis, 030220 oncology & carcinogenesis, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7077658f9fdd79a4e2e918c5298dd47fTest
https://doi.org/10.1016/j.ejmech.2017.12.041Test -
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المؤلفون: Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi
المصدر: Journal of Medicinal Chemistry. 60:5521-5542
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Lactams, Stereochemistry, medicine.drug_class, Administration, Oral, Carboxamide, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Humans, Structure–activity relationship, Protein Kinase Inhibitors, ADME, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Chemistry, Active site, Isoquinolines, IRAK4, Combinatorial chemistry, Interleukin-1 Receptor-Associated Kinases, 030104 developmental biology, Lipophilic efficiency, Lipophilicity, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d71e108dde9e50f577dacbc8e3364eTest
https://doi.org/10.1021/acs.jmedchem.7b00231Test -
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المؤلفون: Brian Juba, Robert Hughes, Mihir D. Parikh, Erin McCarthy, John I. Trujillo, John Robert Springer, Li Xing, Venkataraman Thanabal, Kyung-Hee Kim, Arthur J. Wittwer, Daniel P. Walker, Dean Messing, Nancy L. Wood, Margaret L. Grapperhaus, Nicole Caspers, Zhao-Kui Wan, John Douhan, Shashi Mohan, Mark E. Schnute, Seungil Han, Stephen E. Benoit, Jeffrey F. Ohren, Ingrid P. Buchler, Shaun R. Selness, Thomas N. O'Connell, Jane M. Withka, Michelle Schmidt, Joy S. Miyashiro, Christoph W. Zapf, Nelson Huang, Erica Liu, Rajeev Hotchandani
المصدر: ACS medicinal chemistry letters. 10(1)
مصطلحات موضوعية: chemistry.chemical_classification, biology, 010405 organic chemistry, medicine.drug_class, Stereochemistry, Organic Chemistry, Carboxamide, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Enzyme, chemistry, Covalent bond, hemic and lymphatic diseases, Drug Discovery, medicine, biology.protein, Transferase, Bruton's tyrosine kinase, Cyanamide, Kinome, Tyrosine kinase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07c11f4a26356814edcf89f088b8087Test
https://pubmed.ncbi.nlm.nih.gov/30655951Test -
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المؤلفون: Martin Hegen, David C. Wood, Patrik Rhönnstad, Felix Vajdos, Atli Thorarensen, Mark E. Schnute, Timothy Braden, Kimberly Crouse, Maria Sjöberg, John I. Trujillo, Ravi G. Kurumbail, Bolette Husman, Konrad F. Koehler, Mattias Wennerstål, Tomas Bonn, Joakim Löfstedt, Eva Backström-Rydin, Bo Carlsson, Aron Sundell, Ming Z. Chen, Steven E. Heasley, John David Trzupek, Annika Goos-Nilsson, Carol A. Menard, Peter Harris, James R. Kiefer, Martin Bengtsson, Leon P. Collis, Michael J. Prinsen, Philippe Nuhant, Jennifer Alley, Scott A. Long, Alexander E. Hromockyj, Andrew C. Flick, Johnny Sandberg, Christoph W. Zapf, Edouard Zamaratski, Xiao Hu, Lee Napierata, Björn Kauppi, Nicole Caspers, Kimberly F. Fennell, Robert E. Kyne, Gabriel Berstein, Neelu Kaila, Lars Kruger, Wei Li, Li Xing, Ray Unwalla, Elisabet Kallin, Matthew J. Pelc, Susan Fish, James Robert Blinn, Hjalmar Gullberg, Marvin J. Meyers, Scot Richard Mente, Chulho Choi, Falgun Shah, Mathias Färnegårdh, Dean Messing, Peter G. Jones, Yajuan Zhao, Alexandria P. Taylor, Maria Sandström, Charles W. Bolten, Daniel Nöteberg, Robin A. Weinberg, Tomasz Janosik, John D. Knafels, Anna Wilhelmsson
المصدر: Journal of medicinal chemistry. 61(23)
مصطلحات موضوعية: 0301 basic medicine, Drug Inverse Agonism, Stereochemistry, Pyridines, Retinoic acid, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Mice, RAR-related orphan receptor gamma, Drug Discovery, Inverse agonist, Animals, Humans, Benzamide, Receptor, Orphan receptor, 010405 organic chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, Retinoic acid receptor, 030104 developmental biology, chemistry, Nuclear receptor, Drug Design, Molecular Medicine, Th17 Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b335f732a3ffd4d00a80bd0f813c732Test
https://pubmed.ncbi.nlm.nih.gov/30130103Test -
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المؤلفون: Christoph W. Zapf, May Tan, Mario G. Cardozo, Ge Peng, Jennifer Tung, Mcintosh Joel, Arthur T. Sands, Ryan Rountree, Zef Konst, Jordan Ye, Aileen Kelly, Jeffrey H. Wu, Luz Perez, Neil Bence, Timothy Ingallinera, Dahlia Weiss, Mark Noviski, Steve Basham, Austin Tenn-McClellan, Jenny McKinnell, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic, Daniel W. Robbins, Dane E Karr
المصدر: Blood. 134:3805-3805
مصطلحات موضوعية: biology, business.industry, Chronic lymphocytic leukemia, Immunology, Cell Biology, Hematology, Protein degradation, medicine.disease, Biochemistry, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Ubiquitin, Cell culture, hemic and lymphatic diseases, Ibrutinib, biology.protein, Cancer research, Medicine, Bruton's tyrosine kinase, business, Tyrosine kinase, B cell
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6b95ae450ec2bc4afe8f06a32c74d624Test
https://doi.org/10.1182/blood-2019-129262Test -
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المؤلفون: Austin Tenn-McClellan, Hiroko Tanaka, Joseph Juan, Christoph W. Zapf, Katherine Kurylo, Pallavur Sivakumar, Anne-Renee van der Vuurst de Vries, Ryan Rountree, Andria Christianson, Jennifer McKinnell, Ketki Dhamnaskar, Christopher Karim, Thomas Cummins, Frederick Cohen, Paul A. Barsanti, May Tan, Jilliane Bruffey, Asad M. Taherbhoy, Mario G. Cardozo, Chenbo Wang, Szerenke Kiss von Soly, Julie Sheung, Dahlia Weiss, Mark Gallop, Anjanabha Saha, Neil F. Bence, Dane Karr, Jennifa Gosling, Kathleen A. Boyle
المصدر: Cancer Research. 79:2696-2696
مصطلحات موضوعية: Cancer Research, biology, Chemistry, CD3, T cell, CD28, Molecular biology, Ubiquitin ligase, medicine.anatomical_structure, Oncology, biology.protein, medicine, Cytokine secretion, Ligase activity, IL-2 receptor, CD8
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b24a89cb79f0630ba2e238da192ed69dTest
https://doi.org/10.1158/1538-7445.am2019-2696Test -
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المؤلفون: Zhong Li, Judy Lucas, Jonathan D. Bloom, Russell Dushin, Hao Liu, Mercy Otteng, Mark Johnson, Thomas Nittoli, Jeremy I. Levin, Andrea Olland, Jennifer M. Golas, Christoph W. Zapf, Erik Vogan, Antonia A. Nikitenko, Frank Boschelli
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4602-4607
مصطلحات موضوعية: Lung Neoplasms, Macrocyclic Compounds, Transplantation, Heterologous, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Mice, Nude, Pharmaceutical Science, Heterologous, Antineoplastic Agents, Pharmacology, Biochemistry, Hsp90 inhibitor, Mice, Drug Discovery, medicine, Animals, Humans, Potency, HSP90 Heat-Shock Proteins, Binding site, Lung cancer, Molecular Biology, Binding Sites, biology, Chemistry, Organic Chemistry, medicine.disease, Hsp90, Protein Structure, Tertiary, Rats, Transplantation, Benzamides, Microsomes, Liver, biology.protein, Microsome, Molecular Medicine, Biomarkers
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292118865b349b233211d45dbcb33006Test
https://doi.org/10.1016/j.bmcl.2011.05.102Test -
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المؤلفون: Judy Lucas, Russell Dushin, Christoph W. Zapf, Jamie L. McBean, Hao Liu, Jennifer M. Golas, Frank Boschelli, Erik Vogan, Jeremy I. Levin, Jonathan D. Bloom
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3627-3631
مصطلحات موضوعية: Models, Molecular, Macrocyclic Compounds, Lactams, Macrocyclic, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Hsp90 inhibitor, Inhibitory Concentration 50, Mice, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Benzoquinones, Biomarkers, Tumor, Animals, Humans, HSP90 Heat-Shock Proteins, Amines, Molecular Biology, Cell Proliferation, Molecular Structure, biology, Drug discovery, Chemistry, Organic Chemistry, Biological activity, Xenograft Model Antitumor Assays, In vitro, Cell culture, Enzyme inhibitor, Benzamides, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4697a421ffa5a6182e3ba0584b4346Test
https://doi.org/10.1016/j.bmcl.2011.04.102Test
