Celiac Autoimmunity Is Associated With Lower Blood Pressure and Renal Risk in Type 1 Diabetes
| العنوان: | Celiac Autoimmunity Is Associated With Lower Blood Pressure and Renal Risk in Type 1 Diabetes |
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| المؤلفون: | Katherine V. Williams, Ingrid Libman, Christina L Cristaldi, Yihe Huang, Vincent C. Arena, Dorothy J. Becker, Trevor J. Orchard, Rachel G. Miller |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 103:3828-3836 |
| بيانات النشر: | The Endocrine Society, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Renal function, Autoimmunity, Blood Pressure, Context (language use), urologic and male genital diseases, Biochemistry, Gastroenterology, Nephropathy, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, 030225 pediatrics, Diabetes mellitus, Internal medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Cumulative incidence, Prospective Studies, Clinical Research Articles, Type 1 diabetes, business.industry, Incidence, Biochemistry (medical), Pennsylvania, Prognosis, medicine.disease, female genital diseases and pregnancy complications, Celiac Disease, Diabetes Mellitus, Type 1, Blood pressure, Disease Progression, Kidney Failure, Chronic, Female, 030211 gastroenterology & hepatology, Microalbuminuria, business, Biomarkers, Follow-Up Studies, Glomerular Filtration Rate |
| الوصف: | Context Though the long-term consequences of celiac disease (CD) in type 1 diabetes are unclear, CD has been associated with increased prevalence of end-stage renal disease (ESRD) independent of type 1 diabetes. Objective We evaluated whether celiac autoimmunity is related to the cumulative incidence of microalbuminuria [albumin excretion rate (AER) 20 to 200 µg/min], macroalbuminuria (AER >200 µg/min), and ESRD. Design, patients, and methods In the prospective follow-up of the Pittsburgh Epidemiology of Diabetes Complications study of childhood-onset type 1 diabetes, 618 participants were screened for tissue transglutaminase (tTG) antibodies with a clinical assay. Nephropathy outcomes were determined at 25 years of diabetes duration. Results Overall, the 33 subjects (5.3%) with strongly positive tTG levels (≥3 times the upper limit of normal) or a reported clinical history of CD had lower baseline blood pressure and lipid values. At 25 years of diabetes duration, a lower cumulative incidence of macroalbuminuria in strongly positive subjects compared with those with negative serology (3.6% vs 30.0%; P = 0.003) remained significant after adjustment for age, HbA1c, lipid measures, and blood pressure (adjusted P = 0.004). No considerable differences between these subjects and tTG-negative groups were found for microalbuminuria (40.0% vs 57.1%) or ESRD (0 vs 4.1%). Conclusions These findings show that strongly positive celiac autoimmunity status in individuals with childhood-onset type 1 diabetes is associated with lower baseline blood pressure and cholesterol measurements as well as lower macroalbuminuria risk after 25 years of type 1 diabetes duration with no increase in the risk of microalbuminuria or ESRD. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81cf6d413eb519eb2c634ac9b677681Test https://doi.org/10.1210/jc.2018-00908Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c81cf6d413eb519eb2c634ac9b677681 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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