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1دورية أكاديمية
المؤلفون: Esther C. Y. Lee (10586857), Andrew J. McRiner (2512648), Katy E. Georgiadis (10756246), Julie Liu (6557627), Zooey Wang (10756249), Andrew D. Ferguson (1427719), Benjamin Levin (10185539), Moritz von Rechenberg (10586875), Christopher D. Hupp (2377594), Michael I. Monteiro (10586860), Anthony D. Keefe (3622769), Allison Olszewski (2671783), Charles J. Eyermann (1667878), Paolo Centrella (10756252), Yanbin Liu (231378), Shilpi Arora (130546), John W. Cuozzo (1665235), Ying Zhang (40767), Matthew A. Clark (1370337), Christelle Huguet (8932838), Anna Kohlmann (1417150)
مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Ecology, Inorganic Chemistry, Hematology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, DNA-Encoded Chemical Library Screen., SAR, carboxylic acid-containing compounds, hydroxy acid oxidase 1, DNA-Encoded Chemical Library, PK, PH, novel chemical series, non-acid-containing HAO 1 inhibitors, HAO 1 inhibitors, Compound 5, potency, AGXT, exploration, DECL, ADME, Structure-based drug design
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2دورية أكاديمية
المؤلفون: Jeremy S. Disch (1960423), Jennifer M. Duffy (10586854), Esther C. Y. Lee (10586857), Diana Gikunju (8932826), Betty Chan (1342416), Benjamin Levin (10185539), Michael I. Monteiro (10586860), Sarah A. Talcott (10586863), Anthony C. Lau (10586866), Fei Zhou (86034), Anton Kozhushnyan (10586869), Neil E. Westlund (10586872), Patrick B. Mullins (1601887), Yan Yu (56143), Moritz von Rechenberg (10586875), Junyi Zhang (290426), Yelena A. Arnautova (2710522), Yanbin Liu (231378), Ying Zhang (40767), Andrew J. McRiner (2512648), Anthony D. Keefe (3622769), Anna Kohlmann (1417150), Matthew A. Clark (1370337), John W. Cuozzo (1665235), Christelle Huguet (8932838), Shilpi Arora (130546)
مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Plant Biology, Chemical Sciences not elsewhere classified, Click chemistry synthesis, Bispecific Estrogen Receptor α Degr., novel PROTAC binding features, screening, ER α, breast cancer, ER α WT, novel bispecific degrader, bispecific nanomolar degraders, nanomolar ER α binding, alkyne E 3 ligase engagers panel, MCF 7 tumor growth, DNA-encoded chemical library, molecule exemplar 7, DECL, DNA-Encoded Chemical Library Screen., mouse xenograft model, GOF
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المؤلفون: Shilpi Arora, Anna Kohlmann, Christopher D. Hupp, Julie Liu, Christelle Huguet, Allison Olszewski, Moritz von Rechenberg, John W. Cuozzo, Ying Zhang, Katy E Georgiadis, Matthew A. Clark, Esther C.Y. Lee, Charles J. Eyermann, Andrew J. McRiner, Paolo A. Centrella, Michael I Monteiro, Anthony D. Keefe, Benjamin Levin, Andrew D. Ferguson, Zooey Wang, Yanbin Liu
المصدر: Journal of Medicinal Chemistry. 64:6730-6744
مصطلحات موضوعية: Male, Indoles, Crystallography, X-Ray, 01 natural sciences, Chemical library, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Transaminases, 030304 developmental biology, ADME, 0303 health sciences, Oxidase test, Binding Sites, Chemistry, DNA, Metabolism, 0104 chemical sciences, Molecular Docking Simulation, Alcohol Oxidoreductases, Thiazoles, 010404 medicinal & biomolecular chemistry, Biochemistry, Drug Design, Hyperoxaluria, Primary, Molecular Medicine, Glucuronide, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecd410b881fad4a6d7e1db049c6ba5cTest
https://doi.org/10.1021/acs.jmedchem.0c02271Test -
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المؤلفون: Anthony D. Keefe, Jeremy S. Disch, Jennifer Duffy, Esther C. Lee, Diana Gikunju, Betty Chan, Benjamin D. Levin, Michael I. Monteiro, Sarah A. Talcott, Anthony Lau, Fei Zhou, Anton Kozhushnyan, Neil E. Westlund, Patrick B. Mullins, Yan Yu, Moritz von Rechenberg, Junyi Zhang, Yelena Arnautova, Yanbin Liu, Ying Zhang, Andrew J. McRiner, Anna Kohlmann, Matthew A. Clark, John W. Cuozzo, Christelle Huguet, Shilpi Arora
المصدر: Cancer Research. 83:5346-5346
مصطلحات موضوعية: Cancer Research, Oncology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c39832f0b4b2f727dd1b73c76bcc701cTest
https://doi.org/10.1158/1538-7445.am2023-5346Test -
5
المؤلفون: Diana Gikunju, John W. Cuozzo, Yelena A Arnautova, Sarah A Talcott, Neil Westlund, Andrew J. McRiner, Anthony D. Keefe, Yan Yu, Christelle Huguet, Moritz von Rechenberg, Fei Zhou, Jennifer M Duffy, Shilpi Arora, Esther C.Y. Lee, Ying Zhang, Benjamin Levin, Matthew A. Clark, Jeremy S. Disch, Junyi Zhang, Yanbin Liu, Anton Kozhushnyan, Betty Chan, Anthony C Lau, Michael I Monteiro, Patrick B. Mullins, Anna Kohlmann
المصدر: Journal of Medicinal Chemistry. 64:5049-5066
مصطلحات موضوعية: Indoles, Cell Survival, Estrogen receptor, Breast Neoplasms, Chemical library, Small Molecule Libraries, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Aromatase, biology, Chemistry, DNA-encoded chemical library, Estrogen Antagonists, Estrogen Receptor alpha, DNA, Xenograft Model Antitumor Assays, Small molecule, Kinetics, Biochemistry, Click chemistry, biology.protein, Molecular Medicine, Click Chemistry, Female, Linker, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7302cad9922daa210279c4d6224ee0Test
https://doi.org/10.1021/acs.jmedchem.1c00127Test -
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المؤلفون: William Bradshaw, Lara M. Mangravite, Paul Brennan, Ranjita Betarbet, Belinda Slakman, Anthony D. Keefe, Christelle Huguet, V.L. Katis, Nicholas T. Seyfried, Marie-Aude Guié, John P. Guilinger, Allan I. Levey, Carmen Jimenez-Antunez, Christopher James Mulhern, Opher Gileadi, Ying Zhang
المصدر: Alzheimer's & Dementia. 16
مصطلحات موضوعية: Oncology, medicine.medical_specialty, biology, Epidemiology, business.industry, Health Policy, Moesin, CD44, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Intervention (counseling), Internal medicine, biology.protein, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6f1e5674118efbe59a8f12b48a4844d1Test
https://doi.org/10.1002/alz.045915Test -
7
المؤلفون: Xia Tian, Patrick Riley, Diana Gikunju, Ying Zhang, Christopher D. Hupp, Ling Xue, Matthew A. Clark, Betty Chan, Steven Kearnes, Christelle Huguet, Anthony D. Keefe, Dennis Joseph Moccia, John P. Guilinger, Marie-Aude Guié, Christopher James Mulhern, Kevin McCloskey, John W. Cuozzo, Sana Bazzaz, Eric A. Sigel
المصدر: Journal of medicinal chemistry. 63(16)
مصطلحات موضوعية: FOS: Computer and information sciences, Computer Science - Machine Learning, Machine learning, computer.software_genre, Ligands, 01 natural sciences, Quantitative Biology - Quantitative Methods, Machine Learning (cs.LG), Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Protein Kinase Inhibitors, Selection (genetic algorithm), Quantitative Methods (q-bio.QM), 030304 developmental biology, Epoxide Hydrolases, 0303 health sciences, Artificial neural network, business.industry, Estrogen Receptor alpha, DNA, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Proto-Oncogene Proteins c-kit, chemistry, FOS: Biological sciences, Hit rate, Molecular Medicine, Artificial intelligence, A kinase, Neural Networks, Computer, business, computer
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac595c275dc7177a2f02ea7a9d6979caTest
https://pubmed.ncbi.nlm.nih.gov/32525674Test -
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المؤلفون: Andrew D. Ferguson, Usha Narayanan, Christelle Huguet, John P Giulinger, Michael I Monteiro, Matthew A. Clark, Chris Hupp, Mortiz Von Rechenberg, Andrew J. McRiner, Kyle Denton, Anthony D. Keefe, John W. Cuozzo, Shilpi Arora, Sarah A Talcott, Diana Gikunju
المصدر: Molecular Cancer Therapeutics. 18:C049-C049
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Mutation, biology, Oncogene, Drug discovery, Chemistry, Mutant, Cancer, Computational biology, Hit to lead, medicine.disease, medicine.disease_cause, Small molecule, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, medicine, biology.protein, Bruton's tyrosine kinase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::264ca8cf52f2cf4205d1dd345f561dceTest
https://doi.org/10.1158/1535-7163.targ-19-c049Test -
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المؤلفون: Christelle Huguet Perrot
المصدر: Intrinsic Activity. 4:A2.1
مصطلحات موضوعية: Engineering, Engineering management, business.industry, Pharmaceutical engineering, business, Process engineering, Pharmaceutical industry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::97267bf6c439694b6c4921545c040158Test
https://doi.org/10.25006/ia.4.s1-a2.1Test -
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المؤلفون: Bernard Vandenbunder, David R. Morrice, Christelle Huguet, Dave Burt, Corinne Abbadie, Fatima Bouali
المصدر: APOPTOSIS. 4:31-38
مصطلحات موضوعية: Pharmacology, Cancer Research, Programmed cell death, animal structures, Biochemistry (medical), Clinical Biochemistry, Mutant, Pharmaceutical Science, Embryo, Cell Biology, Biology, Molecular biology, Limb bud, IκBα, Apoptosis, embryonic structures, Limb development, REL
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a26090a3c7b923044a5bf0a637a85f6dTest
https://doi.org/10.1023/a:1009678015249Test