المؤلفون: V. Pragathi Masamsetti, Ronnie Ren Jie Low, Ka Sin Mak, Aisling O’Connor, Chris D. Riffkin, Noa Lamm, Laure Crabbe, Jan Karlseder, David C. S. Huang, Makoto T. Hayashi, Anthony J. Cesare

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/dae63874a0924b7f84dd69ccfd135eb0Test

المؤلفون: Rachel Thijssen, Edward Chew, Sarah S. Gabriel, Brandon J. Aubrey, Ashish Bajel, Andrew W. Roberts, Andreas Strasser, Marie Schoumacher, David A. Stroud, Chris D. Riffkin, Claudia Bruedigam, Donia M Moujalled, Natasha S Anstee, Tirta Mario Djajawi, Veronique Litalien, Ruth M. Kluck, Lin Tai, Andrew H. Wei, Thomas David Morley, Zhen Xu, Giovanna Pomilio, Sarah T. Diepstraten, Sarah MacRaild, Axel Kallies, Christoffer Flensburg, Boris Reljic, Steven W. Lane, Maoshan Chen, Catherine Chang, Gemma L. Kelly, David C. S. Huang, Fiona C. Brown, Sébastien Banquet, Michael A. Dengler, Melissa X Shi, Ian J. Majewski

المصدر: Blood. 137:2721-2735

مصطلحات موضوعية: 0301 basic medicine, Myeloid, Chronic lymphocytic leukemia, Apoptosis, Mice, SCID, Biochemistry, Oxidative Phosphorylation, Mice, chemistry.chemical_compound, 0302 clinical medicine, Mice, Inbred NOD, Mice, Knockout, Sulfonamides, Hematology, Indolizines, Myeloid leukemia, Neoplasm Proteins, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, 030220 oncology & carcinogenesis, medicine.drug, medicine.medical_specialty, Programmed cell death, Morpholines, Immunology, Azacitidine, Antineoplastic Agents, 03 medical and health sciences, Cell Line, Tumor, Proto-Oncogene Proteins, Internal medicine, medicine, Animals, Humans, business.industry, Venetoclax, Interleukin-2 Receptor alpha Subunit, Cell Biology, Bridged Bicyclo Compounds, Heterocyclic, Genes, p53, Isoquinolines, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Xenograft Model Antitumor Assays, Peptide Fragments, 030104 developmental biology, chemistry, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, CRISPR-Cas Systems, Tumor Suppressor Protein p53, Apoptosis Regulatory Proteins, business, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eddd95d812425ed1bd085adc1b7dd3Test
https://doi.org/10.1182/blood.2020010167Test

المؤلفون: Yumiko Hirokawa, Tirta Mario Djajawi, Victoria G. Shuttleworth, Peter Gibbs, Anuratha Sakthianandeswaren, Guillaume Lessene, Duong Nhu, Oliver M. Sieber, Chris D. Riffkin, Ming-Jie Luo, Michelle Palmieri, Christine A White, David J. Segal, Margaret Lee, Jia-Nan Gong, David C.S. Huang

المصدر: Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 9, Pp 1-4 (2020)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Bh3 mimetic, Cancer therapy, Colorectal cancer, Immunology, Drug development, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Proto-Oncogene Proteins, Organoid, medicine, Animals, Humans, MCL1, lcsh:QH573-671, Venetoclax, business.industry, lcsh:Cytology, Comment, Cell Biology, medicine.disease, Small molecule, Peptide Fragments, In vitro, 030104 developmental biology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Disease Susceptibility, Colorectal Neoplasms, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beee30c08c110deda7815b3893ac9b38Test
http://europepmc.org/articles/PMC7483443Test

المؤلفون: Gemma L. Kelly, Andreas Strasser, David C.S. Huang, François Vaillant, Elizabeth Lieschke, Marco J Herold, Chris D. Riffkin, Jane E. Visvader, Zilu Wang, Catherine Chang, Sarah T. Diepstraten

مصطلحات موضوعية: 0303 health sciences, endocrine system diseases, Point mutation, Mutant, DNA-binding domain, Biology, medicine.disease, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, medicine, Gene, Transcription factor, neoplasms, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8143ec955897b405f88e2e6889c4e6bfTest

المؤلفون: James A. H. Murray, Fabien Melchiore, Natalia Matassova, C. Pedder, Frédéric Colland, Catherine Chang, Levente Ondi, Laura C. A. Galbraith, Pawel Dokurno, Andrew W. Roberts, Chris D. Riffkin, Nolwen Guigal-Stephan, Proszenyák Ágnes, John A. Hickman, Andreas Strasser, Aurélie Studeny, Gaëlle Lysiak-Auvity, András Kotschy, Gemma L. Kelly, Fabienne Gravé, Ghislaine Guasconi, Brandon J. Aubrey, Attila Paczal, Julia Smith, Szlávik Zoltán, Gabor Radics, Brian Lockhart, David C.S. Huang, Maïa Chanrion, Gaëtane Le Toumelin-Braizat, Jia-Nan Gong, Nicolas Cauquil, Szabolcs Sipos, Alan P. Robertson, Giovanna Pomilio, James Edward Paul Davidson, Zoltán B. Szabó, Ana Leticia Maragno, Chris Graham, Marco J Herold, Gábor Blasko, Margs S. Brennan, Anne-Marie Girard, Allan E. Surgenor, Andrew H. Wei, Csékei Márton, Olivier Geneste, Chen I-Jen, Alain Bruno, David J. Segal, Guillaume Lessene, Balázs Bálint, Donia M Moujalled

المصدر: Nature. 538:477-482

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Lymphoma, Antineoplastic Agents, Apoptosis, Bcl-xL, Thiophenes, Pharmacology, Models, Biological, Mice, 03 medical and health sciences, 0302 clinical medicine, Bcl-2-associated X protein, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, MCL1, bcl-2-Associated X Protein, Leukemia, Multidisciplinary, biology, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Myeloid Cell Leukemia Sequence 1 Protein, Pyrimidines, bcl-2 Homologous Antagonist-Killer Protein, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Female, Multiple Myeloma, Bcl-2 Homologous Antagonist-Killer Protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e7ae913cad44eb1a7aa5057ee9d4b1Test
https://doi.org/10.1038/nature19830Test

المؤلفون: Yuan Yao, Jia-Nan Gong, Andrew Spencer, Tiffany Khong, David C.S. Huang, Marco J Herold, Guillaume Lessene, Andrew W. Roberts, Chris D. Riffkin, David J. Segal, Seong Lin Khaw, Jean-Marc Garnier

المصدر: Blood. 128(14)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Cell Survival, Immunology, Antineoplastic Agents, Apoptosis, Biology, Bioinformatics, Ligands, Biochemistry, Small Molecule Libraries, 03 medical and health sciences, Genome editing, immune system diseases, hemic and lymphatic diseases, Internal medicine, Cell Line, Tumor, medicine, Humans, MCL1, Molecular Targeted Therapy, Multiple myeloma, Gene Editing, Hematology, Cancer, Cell Biology, medicine.disease, Myeloid Cell Leukemia Sequence 1 Protein, 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, Cell culture, Cancer research, CRISPR-Cas Systems, Multiple Myeloma, Peptides, Immortalised cell line

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b5e35eefb29adf09e7b838a55896c9Test
https://pubmed.ncbi.nlm.nih.gov/27465916Test

المؤلفون: Andrew W. Roberts, Chris D. Riffkin, David J. Segal, Yuan Yao, Mark F. van Delft, David C.S. Huang, Jia-Nan Gong

المصدر: Blood. 128:5706-5706

مصطلحات موضوعية: Programmed cell death, business.industry, Bortezomib, Venetoclax, Cereblon, Immunology, Cell Biology, Hematology, Pharmacology, medicine.disease, Biochemistry, chemistry.chemical_compound, chemistry, Panobinostat, medicine, MCL1, biological phenomena, cell phenomena, and immunity, business, Multiple myeloma, Lenalidomide, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4ae3573f646707502955261d012e3c36Test
https://doi.org/10.1182/blood.v128.22.5706.5706Test