المؤلفون: Mittal, Nimisha, Davis, Chadwick, McLean, Peter, Calla, Jaeson, Godinez-Macias, Karla, Gardner, Alison, Healey, David, Orjuela-Sanchez, Pamela, Ottilie, Sabine, Chong, Yolanda, Gibson, Christopher, Winzeler, Elizabeth

المصدر: Cell Chemical Biology. 30(5)

مصطلحات موضوعية: Plasmodium, drug discovery, malaria, nuclear hormone receptors, phenotypic screening, siRNA, Animals, Humans, Hepatocytes, Liver, Malaria, Parasites, Plasmodium berghei

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1930j30cTest

المؤلفون: Chong, Yolanda Tze.

الإتاحة: http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=742479&T=FTest

المؤلفون: Cox, Michael J., Jaensch, Steffen, Van de Waeter, Jelle, Cougnaud, Laure, Seynaeve, Daan, Benalla, Soulaiman, Koo, Seong Joo, Van Den Wyngaert, Ilse, Neefs, Jean-Marc, Malkov, Dmitry, Bittremieux, Mart, Steemans, Margino, Peeters, Pieter J., Wegner, Jörg Kurt, Ceulemans, Hugo, Gustin, Emmanuel, Chong, Yolanda T., Göhlmann, Hinrich W. H.

المصدر: Scientific Reports ; volume 10, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41598-020-69354-8Test
https://www.nature.com/articles/s41598-020-69354-8.pdfTest
https://www.nature.com/articles/s41598-020-69354-8Test

المؤلفون: de Hoogt, Ronald, Estrada, Marta F., Vidic, Suzana, Davies, Emma J., Osswald, Annika, Barbier, Michael, Santo, Vitor E., Gjerde, Kjersti, van Zoggel, Hanneke J. A. A., Blom, Sami, Dong, Meng, Narhi, Katja, Boghaert, Erwin, Brito, Catarina, Chong, Yolanda, Sommergruber, Wolfgang, van der Kuip, Heiko, van Weerden, Wytske M., Verschuren, Emmy W., Hickman, John, Graeser, Ralph

المساهمون: Institute for Molecular Medicine Finland, Olli-Pekka Kallioniemi / Principal Investigator, University of Helsinki, Research Group Verschuren Emmy, Lung Cancer Model Systems

مصطلحات موضوعية: COMPLEXITY, Cancer, IMI-PREDECT, 3D, tissue slices, protocols, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: The authors would like to thank Ingrid Verberne for the construction and testing of lentiviral plasmids as well as cell transduction, Katja Valimaki and Antonio Ribeiro for the assistance in TMA construction and IHC. We acknowledge support from the Innovative Medicines Initiative Joint Undertaking (IMI grant agreement no 115188), resources composed of financial contribution from EU-FP7 and EFPIA companies in kind contribution. We also acknowledge support from Fundacao para a Ciencia e Tecnologia (FCT), Portugal (EXPL/BBB-IMG/0363/2013); MFE is the recipient of a PhD fellowship from FCT (SFRH/BD/52208/2013). RG had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.; de Hoogt , R , Estrada , M F , Vidic , S , Davies , E J , Osswald , A , Barbier , M , Santo , V E , Gjerde , K , van Zoggel , H J A A , Blom , S , Dong , M , Narhi , K , Boghaert , E , Brito , C , Chong , Y , Sommergruber , W , van der Kuip , H , van Weerden , W M , Verschuren , E W , Hickman , J & Graeser , R 2017 , ' Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project ' , Scientific data , vol. 4 , 170170 . https://doi.org/10.1038/sdata.2017.170Test; ORCID: /0000-0002-1878-8911/work/39705760; ORCID: /0000-0001-5771-9129/work/41165612; 85034853724; 856a6c8a-e55b-418c-a322-d672345e2fe0; http://hdl.handle.net/10138/231167Test; 000416040900001

الإتاحة: http://hdl.handle.net/10138/231167Test

المؤلفون: Lu, Alex X, Chong, Yolanda T, Hsu, Ian Shen, Strome, Bob, Handfield, Louis-Francois, Kraus, Oren, Andrews, Brenda J, Moses, Alan M

المساهمون: National Science and Engineering Research Council, Canada Research Chairs, Canada Foundation for Innovation, Canadian Institutes of Health Research, Canadian Institute for Advanced Research

المصدر: eLife ; volume 7 ; ISSN 2050-084X

الإتاحة: https://doi.org/10.7554/elife.31872Test
https://cdn.elifesciences.org/articles/31872/elife-31872-v3.pdfTest
https://cdn.elifesciences.org/articles/31872/elife-31872-v3.xmlTest
https://elifesciences.org/articles/31872Test

المؤلفون: Simm, Jaak, Klambauer, Günter, Arany, Adam, Steijaert, Marvin, Wegner, Jörg Kurt, Gustin, Emmanuel, Chupakhin, Vladimir, Chong, Yolanda T., Vialard, Jorge, Buijnsters, Peter, Velter, Ingrid, Vapirev, Alexander, Singh, Shantanu, Carpenter, Anne E., Wuyts, Roel, Hochreiter, Sepp, Moreau, Yves, Ceulemans, Hugo

المساهمون: ChemBioBridge, ExaScience Life Pharma, Flanders Innovation and Entrepreneurship agency, Research Council, KU Leuven, NIH

المصدر: Cell Chemical Biology ; volume 25, issue 5, page 611-618.e3 ; ISSN 2451-9456

مصطلحات موضوعية: Clinical Biochemistry, Drug Discovery, Pharmacology, Molecular Biology, Molecular Medicine, Biochemistry

الإتاحة: https://doi.org/10.1016/j.chembiol.2018.01.015Test
https://api.elsevier.com/content/article/PII:S2451945618300370?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2451945618300370?httpAccept=text/plainTest

المؤلفون: Khojasteh, S Cyrus, Argikar, Upendra A, Driscoll, James P, Heck, Carley JS, King, Lloyd, Jackson, Klarissa D, Jian, Wenying, Kalgutkar, Amit S, Miller, Grover P, Kramlinger, Valerie, Rietjens, Ivonne MCM, Teitelbaum, Aaron M, Wang, Kai, Wei, Cong, Johnson, Benjamin M, Shu, Yue-Zhong, Zhuo, Xiaoliang, Meanwell, Nicholas A, Cerny, Matthew A, Obach, R Scott, Sharma, Raman, Spracklin, Douglas K, Walker, Gregory S, Goracci, Laura, Desantis, Jenny, Valeri, Aurora, Castellani, Beatrice, Eleuteri, Michela, Cruciani, Gabriele, Lall, Manjinder S, Bassyouni, Asser, Bradow, James, Brown, Maria, Bundesmann, Mark, Chen, Jinshan, Ciszewski, Gregory, Hagen, Anne E, Hyek, Dennis, Jenkinson, Stephen, Liu, Bo, Pan, Senliang, Reilly, Usa, Sach, Neal, Smaltz, Daniel J, Starr, Jeremy, Wagenaar, Melissa, de Bruyn Kops, Christina, Sicho, Martin, Mazzolari, Angelica, Kirchmair, Johannes, Korprasertthaworn, Porntipa, Chau, Nuy, Nair, Pramod C, Rowland, Andrew, Miners, John O, Wrobleski, Stephen T, Moslin, Ryan, Lin, Shuqun, Zhang, Yanlei, Spergel, Steven, Kempson, James, Tokarski, John S, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Shuster, David, Gillooly, Kathleen, Yang, Xiaoxia, Heimrich, Elizabeth, McIntyre, Kim W, Chaudhry, Charu, Khan, Javed, Ruzanov, Max, Tredup, Jeffrey, Mulligan, Dawn, Xie, Dianlin, Sun, Huadong, Huang, Christine, D'Arienzo, Celia, Aranibar, Nelly, Chiney, Manoj, Chimalakonda, Anjaneya, Pitts, William J, Lombardo, Louis, Carter, Percy H, Burke, James R, Weinstein, David S, Li, Jing, Liu, Ju, Enders, Jennifer, Arciprete, Michael, Tran, Chris, Aluri, Krishna, Guan, Li-Hua, O'Shea, Jonathan, Bisbe, Anna, Charisse, Klaus, Zlatev, Ivan, Najarian, Diana, Xu, Yuanxin, Kim, Jaeah, El Zahar, Noha M, Bartlett, Michael G, Katyayan, Kishore, Yi, Ping, Monk, Scott, Cassidy, Kenneth, Takahashi, Ryan H, Grandner, Jessica M, Bobba, Sudheer, Liu, Yanzhou, Beroza, Paul, Zhang, Donglu, Ma, Shuguang, Post, Noah, Yu, Rosie, Greenlee, Sarah, Gaus, Hans, Hurh, Eunju, Matson, John, Wang, Yanfeng, Tajima, Yuya, Toyoda, Takeshi, Hirayama, Yuichiro, Matsushita, Kohei, Yamada, Takanori, Ogawa, Kumiko, Watanabe, Kenji, Takamura-Enya, Takeji, Totsuka, Yukari, Wakabayashi, Keiji, Miyoshi, Noriyuki, Zhang, Jiayin, Chan, Chi-Kong, Ham, Yat-Hing, Chan, Wan, Schleiff, Mary Alexandra, Flynn, Noah R, Payakachat, Sasin, Schleiff, Benjamin Mark, Pinson, Anna O, Province, Dennis W, Swamidass, S Joshua, Boysen, Gunnar, Nardone-White, Dasean T, Bissada, Jennifer E, Abouda, Arsany A, Zhang, Zhuming, Connolly, Peter J, Lim, Heng Keang, Pande, Vineet, Meerpoel, Lieven, Teleha, Christopher, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy, Luistro, Leopoldo, Packman, Kathryn, Bischoff, James R, Ibrahim, Salam, Parrett, Christopher, Chong, Yolanda, Gottardis, Marco M, Bignan, Gilles, Mulder, Teresa, Bobba, Sudder, Johnson, Kevin M, Wang, Wei, Zhang, Chenghong, Cai, Jingwei, Choo, Edna F, Crawford, James J, Landry, Matthew L, Chen, Huifen, Kenny, Jane R, Lee, Wendy, Young, Wendy B, Geib, Timon, Thulasingam, Madhuranayaki, Haeggstrom, Jesper Z, Sleno, Lekha, Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy GB, Sistare, Frank D

المصدر: Drug Metabolism Reviews 53 (2021) 3
Drug Metabolism Reviews, 53(3), 384-433

مصطلحات موضوعية: METABOLISM, Toxicology, 030226 pharmacology & pharmacy, 03 medical and health sciences, nonp450 enzymes, 0302 clinical medicine, p450 enzymes, Biotransformation, INTRINSIC CLEARANCE, Political science, MASS-BALANCE, Humans, Pharmacology (medical), Pharmacology & Pharmacy, P450 Enzymes, General Pharmacology, Toxicology and Pharmaceutics, ANTISENSE OLIGONUCLEOTIDE, Toxicologie, VLAG, ARISTOLOCHIC ACID, Drug metabolism, Science & Technology, WIMEK, bioactivation, IDENTIFICATION, Year in review, IN-VITRO, NONHEPATOTOXIC DRUGS, Drug metabolizing enzymes, Drug development, 030220 oncology & carcinogenesis, COVALENT BINDING DATA, Engineering ethics, biotransformation, LIVER-MICROSOMES, Life Sciences & Biomedicine

وصف الملف: application/pdf; Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a22a3073b1b8be7c5621703d8a65f67Test
https://doi.org/10.1080/03602532.2021.1916028Test

المؤلفون: de Hoogt, Ronald, Estrada, Marta F., Vidic, Suzana, Davies, Emma J., Osswald, Annika, Barbier, Michaël, Santo, Vitor E., Gjerde, Kjersti, van Zoggel, Hanneke J. A. A., Blom, Sami, Dong, Meng, Narhi, Katja, Boghaert, Erwin, Brito, Catarina, Chong, Yolanda, Sommergruber, Wolfgang, van der Kuip, Heiko, van Weerden, Wytske M., Verschuren, Emmy W., Hickman, John, Graeser, Ralph

المصدر: 2052-4463 ; Scientific Data

مصطلحات موضوعية: Engineering sciences. Technology

وصف الملف: pdf

العلاقة: info:eu-repo/semantics/altIdentifier/isi/000416040900001

الإتاحة: https://doi.org/10.1038/SDATA.2017.170Test
https://hdl.handle.net/10067/1477040151162165141Test
https://repository.uantwerpen.be/docman/irua/24f3cf/147704.pdfTest

المؤلفون: Kraus, Oren Z, Grys, Ben T, Ba, Jimmy, Chong, Yolanda, Frey, Brendan J, Boone, Charles, Andrews, Brenda J

المساهمون: Canada Foundation for Innovation, Ministry of Research and Innovation, Canadian Institutes of Health Research, National Institutes of Health, Connaught Fund

المصدر: Molecular Systems Biology ; volume 13, issue 4 ; ISSN 1744-4292 1744-4292

مصطلحات موضوعية: Applied Mathematics, Computational Theory and Mathematics, General Agricultural and Biological Sciences, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, Information Systems

الإتاحة: https://doi.org/10.15252/msb.20177551Test

المؤلفون: Stock, Kristin, Estrada, Marta F., Vidic, Suzana, Gjerde, Kjersti, Rudisch, Albin, Santo, Vitor E., Barbier, Michael, Blom, Sami, Arundkar, Sharath C., Selvam, Irwin, Osswald, Annika, Stein, Yan, Gruenewald, Sylvia, Brito, Catarina, van Weerden, Wytske, Rotter, Varda, Boghaert, Erwin, Oren, Moshe, Sommergruber, Wolfgang, Chong, Yolanda, de Hoogt, Ronald, Graeser, Ralph

المساهمون: Institute for Molecular Medicine Finland, Olli-Pekka Kallioniemi / Principal Investigator

مصطلحات موضوعية: OVARIAN-CANCER CELLS, BREAST-CANCER, EXTRACELLULAR-MATRIX, SOLID TUMORS, RESISTANCE, GROWTH, FIBROBLASTS, SPHEROIDS, MICROENVIRONMENT, IDENTIFICATION, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: The authors would like to thank Ingrid Verberne for the construction and testing of lentiviral plasmids as well as cell transduction, Katja Valimaki and Antonio Ribeiro for the assistance in TMA construction and IHC. Further, we would want to acknowledge Tauno Metsalu for the generation and constant adaptation of the MBase database for the sample annotations, and Mikael and Johan Lundin for organizing and adapting the Webmicroscope, and annotation of images. We acknowledge support from the Innovative Medicines Initiative Joint Undertaking (IMI grant agreement no. 115188), resources composed of financial contribution from EU-FP7 and EFPIA companies in kind contribution. We also acknowledge support from Fundacao para a Ciencia e Tecnologia (FCT), Portugal (EXPL/BBB-IMG/0363/2013); MFE is the recipient of a PhD fellowship from FCT (SFRH/BD/52208/2013). Finally the authors are very grateful to Emmy Verschuren, Julia Schueler, Liz Anderson, and John Hickman for critically reading the manuscript.; Stock , K , Estrada , M F , Vidic , S , Gjerde , K , Rudisch , A , Santo , V E , Barbier , M , Blom , S , Arundkar , S C , Selvam , I , Osswald , A , Stein , Y , Gruenewald , S , Brito , C , van Weerden , W , Rotter , V , Boghaert , E , Oren , M , Sommergruber , W , Chong , Y , de Hoogt , R & Graeser , R 2016 , ' Capturing tumor complexity in vitro : Comparative analysis of 2D and 3D tumor models for drug discovery ' , Scientific Reports , vol. 6 , 28951 . https://doi.org/10.1038/srep28951Test; ORCID: /0000-0002-1878-8911/work/28930642; 84976897214; ed202e48-21d3-491e-885d-caa822eddb29; http://hdl.handle.net/10138/164974Test; 000378832900001

الإتاحة: http://hdl.handle.net/10138/164974Test