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1دورية أكاديمية
المؤلفون: Yanling Ma, Hong Cai, Julia Smith, Ching-Hsuen Chu, Stephen E. Mercer, Stephanie Boehm, Ivar Mcdonald, Bradley Zinker, Dong Cheng
المصدر: Journal of Lipid Research, Vol 65, Iss 3, Pp 100514- (2024)
مصطلحات موضوعية: Hsd17b13, antisense oligonucleotide, fibrosis, steatosis, CDAHFD, Biochemistry, QD415-436
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S0022227524000191Test; https://doaj.org/toc/0022-2275Test
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2دورية أكاديمية
المؤلفون: Joelle M. Onorato, Ching-Hsuen Chu, Zhengping Ma, Lisa M. Kopcho, Hannguang J. Chao, R.Michael Lawrence, Dong Cheng
المصدر: Journal of Lipid Research, Vol 56, Iss 3, Pp 747-753 (2015)
مصطلحات موضوعية: monoacylglycerol acyltransferase, diacylglycerol acyltransferase, triglycerides, liquid chromatography/mass spectrometry, cell-based assay, Biochemistry, QD415-436
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S0022227520356029Test; https://doaj.org/toc/0022-2275Test
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3دورية أكاديمية
المؤلفون: Zhengping Ma, Ching-Hsuen Chu, Dong Cheng
المصدر: Journal of Lipid Research, Vol 50, Iss 10, Pp 2131-2135 (2009)
مصطلحات موضوعية: fatty acid, acetyl-CoA, obesity, dyslipidemia, Biochemistry, QD415-436
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S0022227520307227Test; https://doaj.org/toc/0022-2275Test
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4دورية أكاديمية
المؤلفون: Haris Jamil, Ching-Hsuen Chu, John K. Dickson, Jr., Ying Chen, Mujing Yan, Scott A. Biller, Richard E. Gregg, John R. Wetterau, David A. Gordon
المصدر: Journal of Lipid Research, Vol 39, Iss 7, Pp 1448-1454 (1998)
مصطلحات موضوعية: lipid transfer protein, protein disulfide isomerase, photoaffinity, benzophenone, HepG2 cells, McArdle RH-7777 cells, Biochemistry, QD415-436
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S0022227520325268Test; https://doaj.org/toc/0022-2275Test
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5دورية أكاديمية
المؤلفون: Huji Turdi (2276449), Hannguang Chao (11530388), Jon J. Hangeland (1705525), Saleem Ahmad (704372), Wei Meng (505670), Robert Brigance (11530391), Guohua Zhao (74327), Wei Wang (17594), Fang Moore (11530394), Xiang-Yang Ye (2306974), Arvind Mathur (144120), Xiaoping Hou (3225315), James Kempson (1665415), Dauh-Rurng Wu (1402558), Yi-Xin Li (1745194), Anthony V. Azzara (1870696), Zhengping Ma (2332414), Ching-Hsuen Chu (2950041), Luping Chen (8402820), Mary Jane Cullen (2499490), Suzanne Rooney (3120585), Susan Harvey (3120579), Lisa Kopcho (5941772), Reshma Panemangelor (11530397), Lynn Abell (6681131), Kevin O’Malley (3534155), William J. Keim (1870714), Elizabeth Dierks (11530400), Shu Chang (747921), Kimberly Foster (4230604), Atsu Apedo (2403871), David Harden (2825804), Marta Dabros (1429852), Qi Gao (133189), Mary Ann Pelleymounter (1870678), Jean M. Whaley (2332450), Jeffrey A. Robl (278983), Dong Cheng (596943), R. Michael Lawrence (2065054), Pratik Devasthale (11530403)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Chemical Sciences not elsewhere classified, potential therapeutic approach, novel chemistry route, multiple preclinical species, liver microsomal metabolism, selective mgat2 inhibitors, selective mgat2 inhibitor, 28e b, 21s b, 21f b, 1 b, aryl dihydropyridinone compound, 50 sub, vivo <, human mgat2, tolerability profile, throughput screening, metabolic disorders, hmgat2 ic, clinical candidate, based liabilities, acceptable safety, 175 nm
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6دورية أكاديمية
المؤلفون: Peter T. W. Cheng (11620166), Robert F. Kaltenbach (2494921), Hao Zhang (15339), Jun Shi (289433), Shiwei Tao (2307016), Jun Li (6494), Lawrence J. Kennedy (2307007), Steven J. Walker (1780573), Yan Shi (166398), Ying Wang (11406), Suresh Dhanusu (11620169), Ramesh Reddigunta (11620172), Selvakumar Kumaravel (11620175), Sutjano Jusuf (1405201), Daniel Smith (6120), Subramaniam Krishnananthan (1402561), Jianqing Li (523126), Tao Wang (12008), Rebekah Heiry (11620178), Chi Shing Sum (2454928), Stephen S. Kalinowski (11620181), Chen-Pin Hung (1745170), Ching-Hsuen Chu (2950041), Anthony V. Azzara (1870696), Milinda Ziegler (11237235), Lisa Burns (397178), Bradley A. Zinker (2521423), Stephanie Boehm (1745227), Joseph Taylor (1730335), Julia Sapuppo (11620184), Kathy Mosure (1834165), Gerry Everlof (1601494), Victor Guarino (1601479), Lisa Zhang (339757), Yanou Yang (1432504), Qian Ruan (2141782), Carrie Xu (1711951), Atsu Apedo (2403871), Sarah C. Traeger (1622287), Mary Ellen Cvijic (1429885), Kimberley A. Lentz (2012935), Giridhar Tirucherai (1469497), Lakshmi Sivaraman (11620187), Jeffrey Robl (11620190), Bruce A. Ellsworth (1870660), Glenn Rosen (539561), David A. Gordon (278984), Matthew G. Soars (3827281), Michael Gill (195307), Brian J. Murphy (1870711)
مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Pharmacology, Immunology, Cancer, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, pulmonary fibrotic diseases, oxycyclohexyl acid bms, multiple preclinical species, excellent overall adme, 986020 (< b, 33 , b, 33 b, 1 sub, b sub, 986278 (< b, k <, >< sub, vivo efficacy, studies starting, nct04308681 ), lung fibrosis, clinical trials, 9 nm
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7
المؤلفون: Brian J. Murphy, Daniel Smith, Julia Sapuppo, Giridhar S. Tirucherai, Lawrence J. Kennedy, Ching-Hsuen Chu, Anthony V. Azzara, Shiwei Tao, Glenn D. Rosen, Subramaniam Krishnananthan, Jun Li, Victor R. Guarino, Lisa Burns, Joseph R. Taylor, Milinda Ziegler, Lakshmi Sivaraman, Bruce A. Ellsworth, Selvakumar Kumaravel, Hao Zhang, Tao Wang, Jun Shi, Atsu Apedo, Dhanusu Suresh, Kathy Mosure, Gerry Everlof, David A. Gordon, Lisa Zhang, Michael Gill, Chen-Pin Hung, Jianqing Li, Peter T. W. Cheng, Robert F. Kaltenbach, Sutjano Jusuf, Ying Wang, Stephanie Boehm, Mary Ellen Cvijic, Matthew G. Soars, Chi Shing Sum, Yan Shi, Jeffrey A. Robl, Reddigunta Ramesh Babu, Bradley A. Zinker, Yanou Yang, Stephen S. Kalinowski, Carrie Xu, Steven J. Walker, Sarah C. Traeger, Rebekah Heiry, Kimberley A. Lentz, Qian Ruan
المصدر: Journal of Medicinal Chemistry. 64:15549-15581
مصطلحات موضوعية: Clinical trial, Pharmacokinetics, In vivo, Chemistry, Drug Discovery, Antagonist, Molecular Medicine, Phases of clinical research, Distribution (pharmacology), Pharmacology, In vitro, ADME
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c00ce908946d21bafba2486eb2e08c90Test
https://doi.org/10.1021/acs.jmedchem.1c01256Test -
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المؤلفون: Shu Chang, Anthony V. Azzara, Yi-Xin Li, Marta Dabros, James Kempson, Reshma Panemangelor, Huji Turdi, Kimberly A. Foster, William J. Keim, Jean M. Whaley, Jeffrey A. Robl, Fang Moore, Luping Chen, Mary Jane Cullen, Xiaoping Hou, Atsu Apedo, R. Michael Lawrence, Arvind Mathur, David G. Harden, Wei Meng, Kevin O'Malley, Mary Ann Pelleymounter, Hannguang Chao, Pratik Devasthale, Jon J. Hangeland, Zhengping Ma, Dauh-Rurng Wu, Robert Paul Brigance, Guohua Zhao, Lynn M. Abell, Qi Gao, Susan Harvey, Lisa M. Kopcho, Dong Cheng, Elizabeth A. Dierks, Ching-Hsuen Chu, Suzanne Rooney, Xiang-Yang Ye, Saleem Ahmad, Wei Wang
المصدر: Journal of Medicinal Chemistry. 64:14773-14792
مصطلحات موضوعية: Metabolism, Metabolic stability, Pharmacology, Crystallography, X-Ray, N-Acetylglucosaminyltransferases, High-Throughput Screening Assays, Structure-Activity Relationship, chemistry.chemical_compound, Metabolic Diseases, chemistry, Pharmacokinetics, Tolerability, In vivo, Drug Discovery, Animals, Humans, Molecular Medicine, Potency, Tetrazole, Enzyme Inhibitors, IC50
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e90999a2854f1a395c0459b5cd876dTest
https://doi.org/10.1021/acs.jmedchem.1c01356Test -
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المؤلفون: Dong Cheng, Bradley A. Zinker, Yi Luo, Petia Shipkova, Claudia H. De Oliveira, Gopal Krishna, Elizabeth A. Brown, Stephanie L. Boehm, Giridhar S. Tirucherai, Huidong Gu, Zhengping Ma, Ching-Hsuen Chu, Joelle M. Onorato, Lisa M. Kopcho, Ron Ammar, Julia Smith, Pratik Devasthale, R. Michael Lawrence, Steven A. Stryker, Elizabeth A. Dierks, Anthony V. Azzara, Leon Carayannopoulos, Edgar D. Charles, Kimberley A. Lentz, David A. Gordon
المصدر: Cell metabolism. 34(11)
مصطلحات موضوعية: Inflammation, Liver Cirrhosis, Adult, Mice, Clinical Trials, Phase I as Topic, Physiology, Non-alcoholic Fatty Liver Disease, Body Weight, Animals, Humans, Cell Biology, Obesity, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394387e9e73eae85eafb5bf7ab1908f8Test
https://pubmed.ncbi.nlm.nih.gov/36323235Test -
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المؤلفون: Peter T W, Cheng, Robert F, Kaltenbach, Hao, Zhang, Jun, Shi, Shiwei, Tao, Jun, Li, Lawrence J, Kennedy, Steven J, Walker, Yan, Shi, Ying, Wang, Suresh, Dhanusu, Ramesh, Reddigunta, Selvakumar, Kumaravel, Sutjano, Jusuf, Daniel, Smith, Subramaniam, Krishnananthan, Jianqing, Li, Tao, Wang, Rebekah, Heiry, Chi Shing, Sum, Stephen S, Kalinowski, Chen-Pin, Hung, Ching-Hsuen, Chu, Anthony V, Azzara, Milinda, Ziegler, Lisa, Burns, Bradley A, Zinker, Stephanie, Boehm, Joseph, Taylor, Julia, Sapuppo, Kathy, Mosure, Gerry, Everlof, Victor, Guarino, Lisa, Zhang, Yanou, Yang, Qian, Ruan, Carrie, Xu, Atsu, Apedo, Sarah C, Traeger, Mary Ellen, Cvijic, Kimberley A, Lentz, Giridhar, Tirucherai, Lakshmi, Sivaraman, Jeffrey, Robl, Bruce A, Ellsworth, Glenn, Rosen, David A, Gordon, Matthew G, Soars, Michael, Gill, Brian J, Murphy
المصدر: Journal of medicinal chemistry. 64(21)
مصطلحات موضوعية: Male, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Pulmonary Fibrosis, Drug Discovery, Animals, Receptors, Lysophosphatidic Acid, Rats
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::80069106f38ceb56aa2828cf9bc68357Test
https://pubmed.ncbi.nlm.nih.gov/34709814Test