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1دورية أكاديمية
المؤلفون: Scott E. Collibee, Antonio Romero, Alexander R. Muci, Darren T. Hwee, Chihyuan Chuang, James J. Hartman, Alykhan S. Motani, Luke Ashcraft, Andre DeRosier, Mark Grillo, Qing Lu, Fady I. Malik, Bradley P. Morgan
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Physiology, Pharmacology, Biotechnology, Virology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, results provide evidence, enabled pharmacological evaluation, cardiac troponin without, cardiac troponin chimera, cardiac troponin activator, cardiac thin filament, cardiac fractional shortening, 5 ± 3, 963 b, 1 b, 3 inhibition led, 2 b, increases cardiac contractility, 3 inhibition, dependent increases, 2 μm, subsequent optimization, increase solubility, identified using, hts hit, dissociation constant
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2دورية أكاديمية
المؤلفون: Chihyuan Chuang (3742285), Scott Collibee (2245519), Luke Ashcraft (11520561), Wenyue Wang (627186), Mark Vander Wal (11520564), Xiaolin Wang (303612), Darren T. Hwee (11520567), Yangsong Wu (11520570), Jingying Wang (4458820), Eva R. Chin (11520573), Peadar Cremin (11520576), Jeanelle Zamora (11520579), James Hartman (2245495), Julia Schaletzky (4923427), Eddie Wehri (10974640), Laura A. Robertson (11520582), Fady I. Malik (324328), Bradley P. Morgan (2245510)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Pharmacology, Biotechnology, Marine Biology, Cancer, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, underlying pathological hypertrophy, hypertrophic cardiomyopathy hypercontractility, genetic hypertrophic cardiomyopathies, cardiac sarcomere may, wide therapeutic window, predicted human half, 2 sub, week window, >< sub, vivo <, rapid improvement, pharmacodynamic relationship, like properties, life (<, indoline compound, important advancement, desired two
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3دورية أكاديمية
المؤلفون: Scott E. Collibee (2702674), Gustave Bergnes (2307355), Chihyuan Chuang (3742285), Luke Ashcraft (11520561), Jeffrey Gardina (11551702), Marc Garard (2245504), Chris R. Jamison (11551705), Kevin Lu (9384001), Pu-Ping Lu (2245531), Alexander Muci (2245489), Antonio Romero (348813), Ellen Valkevich (11551708), Wenyue Wang (627186), Jeffrey Warrington (11551711), Bing Yao (336395), Nickie Durham (11551714), James Hartman (2245495), Anna Marquez (11551717), Aaron Hinken (5961818), Julia Schaletzky (4923427), Donghong Xu (2245525), Darren T. Hwee (11520567), David Morgans (79354), Fady I. Malik (324328), Bradley P. Morgan (2245510)
مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Pharmacology, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, submaximal stimulation frequencies, increases force production, improved free exposure, impaired muscle function, amyotrophic lateral sclerosis, 1 b, vivo <, clinical trials, based optimization
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4
المؤلفون: Aaron C. Hinken, Morgan Bradley P, Bing Yao, Jeffrey Warrington, Antonio A. Romero, Kevin Lu, David J. Morgans, Jeffrey Gardina, James J. Hartman, Chihyuan Chuang, Anna Marquez, Gustave Bergnes, Alexander Muci, Darren T. Hwee, Luke W. Ashcraft, Donghong Xu, Julia Schaletzky, Marc Garard, Ellen Valkevich, Nickie Durham, Pu-Ping Lu, Fady I. Malik, Chris R. Jamison, Scott Collibee, Wenyue Wang
المصدر: Journal of Medicinal Chemistry. 64:14930-14941
مصطلحات موضوعية: medicine.medical_specialty, Dose-Response Relationship, Drug, Molecular Structure, biology, Activator (genetics), Chemistry, Skeletal muscle, Phases of clinical research, Stimulation, medicine.disease, Troponin, Structure-Activity Relationship, medicine.anatomical_structure, Endocrinology, In vivo, Internal medicine, Drug Discovery, medicine, biology.protein, Humans, Molecular Medicine, Potency, Amyotrophic lateral sclerosis, Muscle, Skeletal
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668cbb454d32e106e7cbf776cf29af68Test
https://doi.org/10.1021/acs.jmedchem.1c01067Test -
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المؤلفون: Laura A. Robertson, Julia Schaletzky, Xiaolin Wang, Chihyuan Chuang, Yangsong Wu, James J. Hartman, Jingying Wang, Eddie Wehri, Eva R. Chin, Fady I. Malik, Scott Collibee, Mark Vander Wal, Jeanelle Zamora, Peadar Cremin, Morgan Bradley P, Luke W. Ashcraft, Darren T. Hwee, Wenyue Wang
المصدر: Journal of Medicinal Chemistry. 64:14142-14152
مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Hypertrophic cardiomyopathy, Cytochrome P450, Phases of clinical research, Cardiomyopathy, Hypertrophic, Pharmacology, medicine.disease, Sarcomere, Muscle hypertrophy, Structure-Activity Relationship, Fibrosis, In vivo, Drug Discovery, medicine, biology.protein, Humans, Molecular Medicine, Steady state (chemistry), Cardiac Myosins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57e158c743a4bf8ac97172694a8e35dTest
https://doi.org/10.1021/acs.jmedchem.1c01290Test -
6
المؤلفون: Saswata Sankar Sarkar, James J. Hartman, Darren T. Hwee, Chihyuan Chuang, Peadar Cremin, Andre deRosier, Samantha Edell, Roshni Madhvani, Yangsong Wu, Lisette Yco, Jeanelle Zamora, Anne Murphy, Bradley P. Morgan, Fady I. Malik
المصدر: Biophysical Journal. 122:122a
مصطلحات موضوعية: Biophysics
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6b49ab7795d43ec7ed50966524b63713Test
https://doi.org/10.1016/j.bpj.2022.11.828Test -
7
المؤلفون: James J. Hartman, Fady I. Malik, Julia Schaletzky, Kenneth Lee, Eva R Chin, Yangsong Wu, Bradley P Morgan, Eddie Wehri, Chihyuan Chuang, Darren T. Hwee, Khanha D. Taheri, Preeti Paliwal, Jingying Wang
المصدر: Circulation Research. 125
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Physiology, business.industry, Hypertrophic cardiomyopathy, Cardiac myosin, medicine.disease, Sarcomere, Muscle hypertrophy, Therapeutic approach, Fibrosis, Myosin, medicine, Cardiology and Cardiovascular Medicine, business, Pathological
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::aab40ad3254225a0aeb43ec40ea6e12aTest
https://doi.org/10.1161/res.125.suppl_1.332Test -
8دورية أكاديمية
المؤلفون: Collibee, Scott E., Bergnes, Gustave, Chihyuan Chuang, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R., Kevin Lu, Pu-Ping Lu, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wenyue Wang, Warrington, Jeffrey, Bing Yao, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia
المصدر: Journal of Medicinal Chemistry; 10/28/2021, Vol. 64 Issue 20, p14930-14941, 12p
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9دورية أكاديمية
المؤلفون: Chihyuan Chuang, Collibee, Scott, Ashcraft, Luke, Wenyue Wang, Vander Wal, Mark, Xiaolin Wang, Hwee, Darren T., Yangsong Wu, Jingying Wang, Chin, Eva R., Cremin, Peadar, Zamora, Jeanelle, Hartman, James, Schaletzky, Julia, Wehri, Eddie, Robertson, Laura A., Malik, Fady I., Morgan, Bradley P.
المصدر: Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14142-14152, 11p
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10
المؤلفون: Darren T. Hwee, Kenneth Lee, Fady I. Malik, Chihyuan Chuang, Joseph P. Michel, Julia Schaletzky, Eva R Chin, Todd J. Ewing, Khanha D. Taheri, Preeti Paliwal, Eddie Wehri, Yangsong Wu, Jingying Wang, James J. Hartman, Bradley P Morgan
المصدر: Biophysical Journal. 118:596a
مصطلحات موضوعية: Therapeutic approach, business.industry, Biophysics, Cancer research, Hypertrophic cardiomyopathy, Cardiac myosin, Medicine, business, medicine.disease
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7b12db77c750b2e350e8c25647b4f3d2Test
https://doi.org/10.1016/j.bpj.2019.11.3225Test