المؤلفون: Jorge L. B. Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, Iris Bea L. Ramiro, Julita S. Imperial, Lee S. Leavitt, Jasmine Phan, Fernando A. Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. Michael McIntosh, Vitor Vasconcelos, Baldomero M. Olivera, Joanna Gajewiak

المصدر: Marine Drugs, Vol 22, Iss 3, p 118 (2024)

مصطلحات موضوعية: conotoxin, nAChRs, Constellation Pharmacology, DRG neurons, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1660-3397/22/3/118Test; https://doaj.org/toc/1660-3397Test

الوصول الحر: https://doaj.org/article/eb10793f322b4e929d26fb3a31f6499eTest

المؤلفون: Noemi D. Paguigan (6311693), Jortan O. Tun (6390854), Lee S. Leavitt (10750983), Zhenjian Lin (1320093), Kevin Chase (10449802), Cheryl Dowell (6008708), Cassandra E. Deering-Rice (4675045), Albebson L. Lim (6390851), Manju Karthikeyan (10750995), Ronald W. Hughen (1320087), Jie Zhang (64655), Randall T. Peterson (8596101), Christopher A. Reilly (1957645), Alan R. Light (403240), Shrinivasan Raghuraman (10449811), J. Michael McIntosh (277909), Baldomero M. Olivera (369455), Eric W. Schmidt (226940)

مصطلحات موضوعية: Biochemistry, Neuroscience, Physiology, Pharmacology, Biotechnology, Evolutionary Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, calcium flux assays, 3.1 μ M, nicotinic acetylcholine receptors, nociceptor, compound, acetylcholine-induced calcium flux, nAChR, molleamine, neuroactive, Predatory Sea Slugs, IC 50 values, PN, Molleamine C, Nicotinic Acetylcholine Receptor Pa., muscarinic acetylcholine receptors

العلاقة: https://figshare.com/articles/journal_contribution/Nicotinic_Acetylcholine_Receptor_Partial_Antagonist_Polyamides_from_Tunicates_and_Their_Predatory_Sea_Slugs/14903236Test

الإتاحة: https://doi.org/10.1021/acschemneuro.1c00345.s001Test

المؤلفون: Joanna Gajewiak (1576666), Sean B. Christensen (9131682), Cheryl Dowell (6008708), Fuaad Hararah (10065437), Fernando Fisher (6889730), Peter N. Huynh (10993517), Baldomero M. Olivera (369455), J. Michael McIntosh (277909)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Neuroscience, Pharmacology, Biotechnology, Evolutionary Biology, Ecology, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, α- Conotoxins, pain-related targets, analogue, Conus snails, RgIA -5474, chemotherapy-induced neuropathic pain, Selective Penicillamine Substitutio., acid replacements, Non-Opioid-Based Mechanism Venom-de., α9α10 nAChR, target prey receptors, penicillamine substitutions, α9α10 nAChRs, drug development, non-opioid-based treatment, target nicotinic acetylcholine rece., α- conotoxin RgIA, Potent Analgesic Peptide, disulfide-containing peptides

العلاقة: https://figshare.com/articles/journal_contribution/Selective_Penicillamine_Substitution_Enables_Development_of_a_Potent_Analgesic_Peptide_that_Acts_through_a_Non-Opioid-Based_Mechanism/14807333Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00512.s001Test

المؤلفون: Cheryl Dowell, Zhenjian Lin, Baldomero M. Olivera, Ronald W. Hughen, Randall T. Peterson, Albebson L. Lim, Jie Zhang, Kevin Chase, J. Michael McIntosh, Noemi D. Paguigan, Lee S. Leavitt, Eric W. Schmidt, Shrinivasan Raghuraman, Manju Karthikeyan, Christopher A. Reilly, Cassandra E. Deering-Rice, Jortan O. Tun, Alan R. Light

المصدر: ACS Chem Neurosci

مصطلحات موضوعية: Sympathetic nervous system, Superior cervical ganglion, alpha7 Nicotinic Acetylcholine Receptor, Physiology, Cognitive Neuroscience, Nicotinic Antagonists, Receptors, Nicotinic, Pharmacology, Biochemistry, Article, Mice, Aplysia, Muscarinic acetylcholine receptor, Calcium flux, medicine, Animals, Urochordata, Acetylcholine receptor, Chemistry, Cell Biology, General Medicine, Rats, Nylons, Nicotinic acetylcholine receptor, medicine.anatomical_structure, Nicotinic agonist, Acetylcholine, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c40896a5e2db8adcb614de5f498822aTest
https://doi.org/10.1021/acschemneuro.1c00345Test

المؤلفون: Jack J. Skalicky, Cheryl Dowell, Sean Christensen, Landa Purushottam, Danny Hung-Chieh Chou, Nan Zheng, J. Michael McIntosh

المصدر: J Med Chem

مصطلحات موضوعية: Thioacetal, Peptide, Receptors, Nicotinic, Pharmacology, 01 natural sciences, Article, Structure-Activity Relationship, 03 medical and health sciences, Acetals, In vivo, Drug Discovery, Humans, Sulfhydryl Compounds, 030304 developmental biology, Acetylcholine receptor, chemistry.chemical_classification, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Antagonist, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Nicotinic acetylcholine receptor, Nicotinic agonist, Neuropathic pain, Neuralgia, Molecular Medicine, Conotoxins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca0f852f0630cbe7e84e18cc38c19f5Test
https://doi.org/10.1021/acs.jmedchem.1c00802Test

المؤلفون: J. Michael McIntosh, Baldomero M. Olivera, Fernando Fisher, Peter N. Huynh, Cheryl Dowell, Joanna Gajewiak, Fuaad Hararah, Sean Christensen

المصدر: J Med Chem

مصطلحات موضوعية: Peptide, Nicotinic Antagonists, Receptors, Nicotinic, Pharmacology, complex mixtures, 01 natural sciences, Article, Structure-Activity Relationship, 03 medical and health sciences, Drug Development, Drug Discovery, Conus, medicine, Humans, Receptor, Neuropharmacology, 030304 developmental biology, Acetylcholine receptor, chemistry.chemical_classification, Analgesics, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Penicillamine, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Nicotinic agonist, Opioid, Neuralgia, Molecular Medicine, Conotoxins, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3609bed773a9c06eb7a94415ae1753Test
https://doi.org/10.1021/acs.jmedchem.1c00512Test

المؤلفون: J. Michael McIntosh, Alan Blakely, Cheryl Dowell, Danny Hung-Chieh Chou, Nan Zheng, Landa Purushottam, Sean Christensen

المصدر: J Med Chem

مصطلحات موضوعية: Macrocyclic Compounds, Stereochemistry, Molecular Conformation, Peptide, Nicotinic Antagonists, Receptors, Nicotinic, Peptides, Cyclic, Molecular Docking Simulation, Article, Cone snail, Xenopus laevis, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Receptor, Acetylcholine receptor, chemistry.chemical_classification, Conus Snail, Protein Subunits, Nicotinic acetylcholine receptor, Nicotinic agonist, chemistry, Drug Design, Lactam, Molecular Medicine, Conotoxins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d2ea9e5169b717819e383cdbfcec1cTest
https://doi.org/10.1021/acs.jmedchem.0c00613Test

المؤلفون: Manju Karthikeyan, Jortan O. Tun, Kevin Chase, Lee S. Leavitt, Albebson L. Lim, Shrinivasan Raghuraman, Cheryl Dowell, Ronald W. Hughen, Alan R. Light, Baldomero M. Olivera, J. M. McIntosh, Jie Zhang, Noemi D. Paguigan, Eric W. Schmidt, Christopher A. Reilly, Zhenjian Lin, Cassandra E. Deering-Rice, Randall T. Peterson

مصطلحات موضوعية: Superior cervical ganglion, Sympathetic nervous system, genetic structures, Chemistry, behavioral disciplines and activities, Nicotinic acetylcholine receptor, Nicotinic agonist, medicine.anatomical_structure, nervous system, Calcium flux, Muscarinic acetylcholine receptor, Biophysics, medicine, psychological phenomena and processes, Acetylcholine, medicine.drug, Acetylcholine receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a93867834e3506529c91e592477639baTest
https://doi.org/10.1101/2021.05.17.444536Test

المؤلفون: Cecilia Gotti, Cheryl Dowell, Susanna Pucci, Francesca Fasoli, Roberta Benfante, Michael McIntosh, Annalisa Maroli, Milena Moretti, Marco Pallavicini, Cristiano Bolchi, Francesco Clementi, Simona Di Lascio, Vanessa Mucchietto

المصدر: British Journal of Pharmacology. 175:1957-1972

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, MAPK/ERK pathway, A549 cell, Chemistry, Cell growth, Nicotine, 03 medical and health sciences, 030104 developmental biology, Nicotinic agonist, Cancer research, medicine, Receptor, Protein kinase B, medicine.drug, Acetylcholine receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fca230d223d08764967fa52d00b797e2Test
https://doi.org/10.1111/bph.13954Test

المؤلفون: Vanessa Mucchietto, Susanna Pucci, Milena Moretti, Carmen Lammi, Clara De Palma, J. Michael McIntosh, Francesca Fasoli, Roberta Budriesi, Irene Corradini, Donatella Lattuada, Francesco Clementi, Cristiano Bolchi, Cheryl Dowell, Francesco Bavo, Paola Viani, Cecilia Gotti, Marco Pallavicini

المساهمون: Bavo, Francesco, Pucci, Susanna, Fasoli, Francesca, Lammi, Carmen, Moretti, Milena, Mucchietto, Vanessa, Lattuada, Donatella, Viani, Paola, De Palma, Clara, Budriesi, Roberta, Corradini, Irene, Dowell, Cheryl, McIntosh, J. Michael, Clementi, Francesco, Bolchi, Cristiano, Gotti, Cecilia, Pallavicini, Marco

المصدر: Journal of medicinal chemistry. 61(23)

مصطلحات موضوعية: 0301 basic medicine, Pterostilbene, alpha7 Nicotinic Acetylcholine Receptor, Stereochemistry, Ether, Antineoplastic Agents, Receptors, Nicotinic, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Stilbenes, Humans, Receptor, Acetylcholine receptor, Cell Proliferation, Drug Discovery3003 Pharmaceutical Science, Antagonist, 030104 developmental biology, Nicotinic agonist, chemistry, Cell culture, 030220 oncology & carcinogenesis, Molecular Medicine, Glioblastoma, Reactive Oxygen Species, Linker

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb4b1d0bde4242864b3eb50bfe63f60Test
https://pubmed.ncbi.nlm.nih.gov/30403486Test