دورية أكاديمية
Genomics to select treatment for patients with metastatic breast cancer.
| العنوان: | Genomics to select treatment for patients with metastatic breast cancer. |
|---|---|
| المؤلفون: | Andre, F., Filleron, T., Kamal, M., Mosele, F., Arnedos, M., Dalenc, Florence, Sablin, M. P., Campone, M., Bonnefoi, H., Lefeuvre-Plesse, Claudia, Jacot, William, Coussy, F., Ferrero, J. M., Emile, G., Mouret-Reynier, Marie Ange, Thery, J. C., Isambert, Nicolas, Mege, A., Barthelemy, Philippe, You, B., Hajjaji, Nawale, Lacroix, L., Rouleau, E., Tran-Dien, A., Boyault, S., Attignon, V., Gestraud, Pierre, Servant, N., Le Tourneau, C., Cherif, L. L., Soubeyran, I., Montemurro, F., Morel, A., Lusque, A., Jimenez, M., Jacquet, A., Gonçalves, A., Bachelot, T., Bieche, I. |
| المساهمون: | Université de Lille, Inserm, CHU Lille, Institut Gustave Roussy IGR, Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse U981, Institut Claudius Regaud, Institut Curie - Saint Cloud ICSC, Institut de Cancérologie de l'Ouest Angers/Nantes UNICANCER/ICO, Institut Bergonié Bordeaux, CRLCC Eugène Marquis CRLCC, Institut de Recherche en Cancérologie de Montpellier IRCM - U1194 Inserm - UM, Centre de Lutte contre le Cancer Antoine Lacassagne Nice UNICANCER/CAL, Centre Jean Perrin Clermont-Ferrand UNICANCER/CJP, Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen CLCC Henri Becquerel, Département d'oncologie médicale Centre Georges-François Leclerc, Centre Régional de Lutte contre le cancer Georges-François Leclerc Dijon UNICANCER/CRLCC-CGFL, Institut Sainte Catherine Avignon, Institut de Cancérologie de Strasbourg Europe ICANS, Université Claude Bernard Lyon 1 UCBL, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192, Centre Léon Bérard Lyon, Mines Paris - PSL (École nationale supérieure des mines de Paris), CRLCC - Centre Paul Papin CRLCC Paul Papin, Institut Cochin IC UM3 (UMR 8104 / U1016), Institut Curie Paris |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| الوصف: | Cancer progression is driven in part by genomic alterations1. The genomic characterization of cancers has shown interpatient heterogeneity regarding driver alterations2, leading to the concept that generation of genomic profiling in patients with cancer could allow the selection of effective therapies3,4. Although DNA sequencing has been implemented in practice, it remains unclear how to use its results. A total of 1,462 patients with HER2-non-overexpressing metastatic breast cancer were enroled to receive genomic profiling in the SAFIR02-BREAST trial. Two hundred and thirty-eight of these patients were randomized in two trials (nos. NCT02299999 and NCT03386162) comparing the efficacy of maintenance treatment5 with a targeted therapy matched to genomic alteration. Targeted therapies matched to genomics improves progression-free survival when genomic alterations are classified as level I/II according to the ESMO Scale for Clinical Actionability of Molecular Targets (ESCAT)6 (adjusted hazards ratio (HR): 0.41, 90% confidence interval (CI): 0.27–0.61, P < 0.001), but not when alterations are unselected using ESCAT (adjusted HR: 0.77, 95% CI: 0.56–1.06, P = 0.109). No improvement in progression-free survival was observed in the targeted therapies arm (unadjusted HR: 1.15, 95% CI: 0.76–1.75) for patients presenting with ESCAT alteration beyond level I/II. Patients with germline BRCA1/2 mutations (n = 49) derived high benefit from olaparib (gBRCA1: HR = 0.36, 90% CI: 0.14–0.89; gBRCA2: HR = 0.37, 90% CI: 0.17–0.78). This trial provides evidence that the treatment decision led by genomics should be driven by a framework of target actionability in patients with metastatic breast cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | Nature; http://hdl.handle.net/20.500.12210/92593Test |
| الإتاحة: | https://doi.org/20.500.12210/92593Test https://hdl.handle.net/20.500.12210/92593Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.5EFDD122 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |