دورية أكاديمية
Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats
| العنوان: | Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats |
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| المؤلفون: | Jing Meng, Jingzhuo Tian, Yong Zhao, Chunying Li, Yan Yi, Yushi Zhang, Jiayin Han, Lianmei Wang, Chen Pan, Suyan Liu, Chenyue Liu, Fang Wang, Xuan Tang, Dunfang Wang, Shasha Qin, Aihua Liang |
| المصدر: | Heliyon, Vol 9, Iss 4, Pp e15333- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Cheqianzi decoction (CQD), Hyperuricemia (HUA), Kidney injury, ABCG2, NLRP3, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Cheqianzi Decoction (CQD) is a Traditional Chinese Medicine (TCM) formula comprising four herbs and is recorded in the Ancient Materia Medica “Shengji Zonglu”. Individually, these four herbs have been shown to reduce uric acid (UA) levels, to treat hyperuricemia (HUA), and alleviate kidney damage. However, the therapeutic efficacy of the CQD and related mechanism are not yet clear.In this study, high performance liquid chromatography (HPLC) analysis confirmed that the contents of the chemical components of the four herbal medicines were in accordance with the provisions of the Chinese Pharmacopoeia. A total of 99 potential targets were identified in the network pharmacology analysis of CQD, indicating its involvement in the regulation of inflammatory and apoptotic signaling pathways, and potential value for treating HUA and alleviating kidney injury. In vivo pharmacodynamic studies showed that compared with the Model group, significantly decreased levels of serum uric acid (SUA), serum creatinine (SCr), blood urea nitrogen (BUN) (all P < 0.05), and inflammatory factors (P < 0.01) were detected in the CQD group. Quantitative real-time PCR and Western blot analyses showed that compared with the Model group, adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) expression in the CQD group was significantly upregulated (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405844023025409Test; https://doaj.org/toc/2405-8440Test |
| DOI: | 10.1016/j.heliyon.2023.e15333 |
| الوصول الحر: | https://doaj.org/article/56b543a5973b4be782f387603d68fcdeTest |
| رقم الانضمام: | edsdoj.56b543a5973b4be782f387603d68fcde |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e15333 |