دورية أكاديمية
Evaluation of Four Genetic Variants in Han Chinese Subjects with High Myopia
| العنوان: | Evaluation of Four Genetic Variants in Han Chinese Subjects with High Myopia |
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| المؤلفون: | Zimeng Ye, Huaichao Luo, Bo Gong, Ying Lin, Ping Shuai, Pu Wang, Changning Ye, Zhenglin Yang, Wanjun Wang, Yi Shi |
| المصدر: | Journal of Ophthalmology, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | Ophthalmology, RE1-994 |
| الوصف: | High myopia is one of the leading causes of blindness worldwide. However, the exact etiology of high myopia remains unraveled despite numerous attempts of elucidation. Previous genome-wide association study (GWAS) has revealed that four single nucleotide polymorphisms (SNPs), including rs2969180, rs1652333, rs9307551, and rs7837791, were associated with high myopia in Caucasians. The present study was conducted to investigate whether these genetic variants were associated with high myopia in Han Chinese. These four SNPs were genotyped by SNaPshot method in a Han Chinese cohort composed of 827 patients with high myopia and 988 healthy controls. Among the SNPs genotyped, only rs9307551 was found to be significantly associated with high myopia in this study. Carriers of rs9307551A allele, AA, and AC genotypes had an increased risk of high myopia (OR = 1.33, 95% CI 1.14–1.54; OR = 1.75, 95% CI 1.28–2.38; OR = 1.59, 95% CI 1.24–2.01, resp.). Interestingly, when split by gender, the association between rs9307551 and high myopia proved to be gender-specific with significance observed only in females but not males. These findings suggested that the SNP of rs9307551 showed a gender-specific association with high myopia in the Han Chinese population. In addition, LOC100506035, a lincRNA gene, might play a crucial role in the susceptibility to high myopia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-004X 2090-0058 |
| العلاقة: | https://doaj.org/toc/2090-004XTest; https://doaj.org/toc/2090-0058Test |
| DOI: | 10.1155/2015/729463 |
| الوصول الحر: | https://doaj.org/article/d7573e4bfb4f440aa715e90820eed9efTest |
| رقم الانضمام: | edsdoj.7573e4bfb4f440aa715e90820eed9ef |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2090004X 20900058 |
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| DOI: | 10.1155/2015/729463 |