نتائج البحث - "Chan, Kwok-Ho"

1

دورية أكاديمية

Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3

المؤلفون: Röth, Sascha, Kocaturk, Nur Mehpare, Sathyamurthi, Preethi S., Carton, Bill, Watt, Matthew, Macartney, Thomas J., Chan, Kwok-Ho, Isidro-Llobet, Albert, Konopacka, Agnieszka, Queisser, Markus A., Sapkota, Gopal P.

المصدر: Röth , S , Kocaturk , N M , Sathyamurthi , P S , Carton , B , Watt , M , Macartney , T J , Chan , K-H , Isidro-Llobet , A , Konopacka , A , Queisser , M A & Sapkota , G P 2023 , ' Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3 ' , Cell Chemical Biology , vol. 30 , no. 10 , pp. 1261-1276.e7 . https://doi.org/10.1016/j.chembiol.2023.07.006Test

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/cce1c275-76ee-4fb5-93f7-4f392856e213Test

الإتاحة: https://doi.org/10.1016/j.chembiol.2023.07.006Test
https://discovery.dundee.ac.uk/en/publications/cce1c275-76ee-4fb5-93f7-4f392856e213Test
https://discovery.dundee.ac.uk/ws/files/115194467/PIIS2451945623002337.pdfTest
http://www.scopus.com/inward/record.url?scp=85173796751&partnerID=8YFLogxKTest

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2

دورية أكاديمية

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

المؤلفون: Bond, Adam G., Craigon, Conner, Chan, Kwok-Ho, Testa, Andrea, Karapetsas, Athanasios, Fasimoye, Rotimi, Macartney, Thomas, Blow, J. Julian, Alessi, Dario R., Ciulli, Alessio

المساهمون: Medical Research Council, Medical Research Scotland, H2020 Societal Challenges, Wellcome Trust, FP7 Ideas: European Research Council

المصدر: Journal of Medicinal Chemistry ; volume 64, issue 20, page 15477-15502 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01532Test

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3

دورية أكاديمية

Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

المؤلفون: Roth, Sascha, Macartney, Thomas, Konopacka, Agnieszka, Chan, Kwok-Ho, Zhou, Houjiang, Queisser, Markus A., Sapkota, Gopal

المصدر: Roth , S , Macartney , T , Konopacka , A , Chan , K-H , Zhou , H , Queisser , M A & Sapkota , G 2020 , ' Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System ' , Cell Chemical Biology , vol. 27 , no. 9 , pp. 1151-1163.e6 . https://doi.org/10.1016/j.chembiol.2020.06.012Test

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/885c077c-beba-4ed3-84bb-0ee8f06c4716Test

الإتاحة: https://doi.org/10.1016/j.chembiol.2020.06.012Test
https://discovery.dundee.ac.uk/en/publications/885c077c-beba-4ed3-84bb-0ee8f06c4716Test
https://discovery.dundee.ac.uk/ws/files/51970929/1_s2.0_S245194562030235X_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85089297813&partnerID=8YFLogxKTest

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4

دورية أكاديمية

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

المؤلفون: Klein, Victoria G., Townsend, Chad E., Testa, Andrea, Zengerle, Michael, Maniaci, Chiara, Hughes, Scott J., Chan, Kwok-Ho, Ciulli, Alessio, Lokey, R. Scott

المصدر: Klein , V G , Townsend , C E , Testa , A , Zengerle , M , Maniaci , C , Hughes , S J , Chan , K-H , Ciulli , A & Lokey , R S 2020 , ' Understanding and Improving the Membrane Permeability of VH032-Based PROTACs ' , ACS Medicinal Chemistry Letters , vol. 11 , no. 9 , pp. 1732-1738 . https://doi.org/10.1021/acsmedchemlett.0c00265Test

مصطلحات موضوعية: Selective degradation, PAMPA, LPE, permeability, structure-permeability relationships, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/99830788-76a7-40e4-a8a7-a7b65e0c4271Test

الإتاحة: https://doi.org/10.1021/acsmedchemlett.0c00265Test
https://discovery.dundee.ac.uk/en/publications/99830788-76a7-40e4-a8a7-a7b65e0c4271Test
https://discovery.dundee.ac.uk/ws/files/51276394/acsmedchemlett.0c00265.pdfTest
http://www.scopus.com/inward/record.url?scp=85092552569&partnerID=8YFLogxKTest

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5

دورية أكاديمية

Correction to “3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation”

المؤلفون: Testa, Andrea, Lucas, Xavier, Castro, Guilherme V., Chan, Kwok-Ho, Wright, Jane E., Runcie, Andrew C., Gadd, Morgan S., Harrison, William T. A., Ko, Eun-Jung, Fletcher, Daniel, Ciulli, Alessio

المصدر: Journal of the American Chemical Society ; volume 141, issue 18, page 7644-7644 ; ISSN 0002-7863 1520-5126

مصطلحات موضوعية: Colloid and Surface Chemistry, Biochemistry, General Chemistry, Catalysis

الإتاحة: https://doi.org/10.1021/jacs.9b03833Test

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6

دورية أكاديمية

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

المؤلفون: Baud, Matthias G. J., Lin-Shiao, Enrique, Cardote, Teresa, Tallant, Cynthia, Pschibul, Annica, Chan, Kwok-Ho, Zengerle, Michael, Garcia, Jordi R., Kwan, Terence T.-L., Ferguson, Fleur M., Ciulli, Alessio

المصدر: Science, 2014 Oct . 346(6209), 638-641.

الوصول الحر: https://www.jstor.org/stable/24917539Test

7

دورية أكاديمية

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

المؤلفون: Testa, Andrea, Lucas, Xavier, Castro, Guilherme V., Chan, Kwok-Ho, Wright, Jane E., Runcie, Andrew C., Gadd, Morgan S., Harrison, William T. A., Ko, Eun-Jung, Fletcher, Daniel, Ciulli, Alessio

المساهمون: H2020 Marie Sklodowska-Curie Actions, Wellcome Trust, FP7 Ideas: European Research Council, Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, Biotechnology and Biological Sciences Research Council

المصدر: Journal of the American Chemical Society ; volume 140, issue 29, page 9299-9313 ; ISSN 0002-7863 1520-5126

الإتاحة: https://doi.org/10.1021/jacs.8b05807Test

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8

دورية أكاديمية

Structural basis of PROTAC cooperative recognition for selective protein degradation

المؤلفون: Gadd, Morgan S, Testa, Andrea, Lucas, Xavier, Chan, Kwok-Ho, Chen, Wenzhang, Lamont, Douglas J, Zengerle, Michael, Ciulli, Alessio

وصف الملف: application/pdf

العلاقة: https://eprints.lancs.ac.uk/id/eprint/89193/1/18267_2_merged_1485892873.pdfTest; Gadd, Morgan S and Testa, Andrea and Lucas, Xavier and Chan, Kwok-Ho and Chen, Wenzhang and Lamont, Douglas J and Zengerle, Michael and Ciulli, Alessio (2017) Structural basis of PROTAC cooperative recognition for selective protein degradation. Nature Chemical Biology, 13 (5). pp. 514-521. ISSN 1552-4450

الإتاحة: https://doi.org/10.1038/nchembio.2329Test
https://eprints.lancs.ac.uk/id/eprint/89193Test/
https://eprints.lancs.ac.uk/id/eprint/89193/1/18267_2_merged_1485892873.pdfTest

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9

دورية أكاديمية

Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

المؤلفون: Chan, Kwok-Ho, Zengerle, Michael, Testa, Andrea, Ciulli, Alessio

المساهمون: H2020 Marie Sklodowska-Curie Actions, Wellcome Trust, FP7 Ideas: European Research Council, Biotechnology and Biological Sciences Research Council

المصدر: Journal of Medicinal Chemistry ; volume 61, issue 2, page 504-513 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.6b01912Test

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10

دورية أكاديمية

Screening of E3 Ligases Uncovers KLHDC2 as an Efficient Proximity-Induced Degrader of K-RAS, STK33, β-catenin and FoxP3

المؤلفون: Röth, Sascha, Carton, Bill, Sathyamurthi, Preethi S., Watt, Matthew, Macartney, Thomas J., Chan, Kwok-Ho, Isidro-Llobet, Albert, Konopacka, Agnieszka, Queisser, Markus A., Sapkota, Gopal

المصدر: SSRN Electronic Journal ; ISSN 1556-5068

الإتاحة: https://doi.org/10.2139/ssrn.4214930Test

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