التفاصيل البيبلوغرافية
| العنوان: |
Combined drug therapeutic strategies for the effective treatment of Triple Negative Breast Cancer |
| المؤلفون: |
Chalakur-Ramireddy, Naveen K.R., Pakala, Suresh B. |
| المصدر: |
Bioscience Reports ; volume 38, issue 1 ; ISSN 0144-8463 1573-4935 |
| بيانات النشر: |
Portland Press Ltd. |
| سنة النشر: |
2018 |
| الوصف: |
TNBC (Triple Negative Breast Cancer) is a subtype of breast cancer with an aggressive phenotype which shows high metastatic capability and poor prognosis. Owing to its intrinsic properties like heterogeneity, lack of hormonal receptors and aggressive phenotype leave chemotherapy as a mainstay for the treatment of TNBC. Various studies have demonstrated that chemotherapy alone or therapeutic drugs targeting TNBC pathways, epigenetic mechanisms and immunotherapy alone have not shown significant improvement in TNBC patients. On the other hand, a combination of therapeutic drugs or addition of chemotherapy with therapeutic drugs has shown substantial improvement in results and proven to be an effective strategy for TNBC treatment. This review sheds light on effective combinational drug strategies and current clinical trial status of various combinatorial drugs for the treatment of TNBC. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1042/bsr20171357 |
| DOI: |
10.1042/BSR20171357/429847/bsr-2017-1357.pdf |
| الإتاحة: |
https://doi.org/10.1042/bsr20171357Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.FEB402A8 |
| قاعدة البيانات: |
BASE |
