التفاصيل البيبلوغرافية
| العنوان: |
Clinical impact of gender and age at onset on disease trajectory in primary progressive multiple sclerosis patients |
| المؤلفون: |
Camerlingo, Sebastian, Rubinstein, Fernando, Celia Ysrraelit, Maria, Correale, Jorge, Carnero Contentti, Edgar, Rojas, Juan I, Patrucco, Liliana, Leguizamon, Felisa del Valle, Tkachuk, Veronica, Fernandez Liguori, Nora, Cristiano, Edgardo, Mainella, Carolina, Zanga, Gisela, Carra, Adriana, Marrodan, Mariano, Martinez, Alejandra Diana, Silva, Berenice Anabel, Alonso, Ricardo |
| المصدر: |
Multiple Sclerosis Journal ; volume 30, issue 3, page 336-344 ; ISSN 1352-4585 1477-0970 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Neurology (clinical), Neurology |
| الوصف: |
Background and Objectives: Primary-progressive multiple sclerosis (PPMS) is characterized by gradual neurological deterioration without relapses. This study aimed to investigate the clinical impact of gender and age at disease onset on disease progression and disability accumulation in patients with this disease phenotype. Methods: Secondary data from the RelevarEM registry, a longitudinal database in Argentina, were analyzed. The cohort comprised patients with PPMS who met inclusion criteria. Statistical analysis with multilevel Bayesian robust regression modeling was conducted to assess the associations between gender, age at onset, and Expanded Disability Status Scale (EDSS) score trajectories. Results: We identified 125 patients with a confirmed diagnosis of PPMS encompassing a total of 464 observations. We found no significant differences in EDSS scores after 10 years of disease progression between genders (−0.08; credible interval (CI): −0.60, 0.42). A 20-year difference in age at onset did not show significant differences in EDSS score after 10 years of disease progression (0.281; CI: −0.251, 0.814). Finally, we also did not find any clinically relevant difference between gender EDSS score with a difference of 20 years in age at onset (−0.021; CI: −0.371, 0.319). Conclusion: Biological plausibility of gender and age effects does not correlate with clinical impact measured by EDSS score. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/13524585231219138 |
| الإتاحة: |
https://doi.org/10.1177/13524585231219138Test |
| حقوق: |
https://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.269F1F4F |
| قاعدة البيانات: |
BASE |
